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This section provides an overview for triazole as well as their applications and principles. Also, please take a look at the list of 28 triazole manufacturers and their company rankings. Here are the top-ranked triazole companies as of December, 2024: 1.AlzChem, LLC, 2.Johoku Chemical, 3.Otsuka Chemical Co.,Ltd..
Table of Contents
Triazole is a five-membered ring compound with three nitrogen atoms and two carbon atoms, having the chemical formula C2H3N3. There are two isomeric forms: 1,2,3-triazole and 1,2,4-triazole, both exhibiting aromatic properties.
Triazole is used in pharmaceuticals, with each isomer being a component of different drugs.
1,2,3-Triazole is an important component in the antibiotic tazobactam piperacillin for injection, used to treat conditions like complicated cystitis, pyelonephritis, pneumonia, peritonitis, sepsis, and febrile neutropenia.
1,2,3-Triazole is crystalline, sweet-tasting, and has a melting point of 23-25 °C and a boiling point of 203 °C. It is soluble in water and ethanol. At temperatures above 500 °C in a vacuum, it decomposes, releasing nitrogen to form aziridine.
Triazole forms a five-membered ring with two carbon and three nitrogen atoms. 1,2,3-Triazole, with adjacent nitrogen atoms, is exceptionally stable. In aqueous solution, it forms tautomers such as 2H-1,2,3-triazole.
Substituted 1,2,3-triazole can be synthesized by Huisgen cycloaddition, a 1,3-dipolar cycloaddition reaction of an azide with an alkyne, useful in click chemistry. The Dimroth rearrangement is an example of ring-chain tautomerism involving 1,2,3-triazole.
1,2,4-Triazole is a colorless, needle-like crystal with melting and boiling points of 120 °C and 260 °C, respectively. It is planar and soluble in water and ethanol. 1,2,4-triazole undergoes both N-protonation and deprotonation in aqueous solution. It is a key component of the antifungal drug fluconazole.
Unsubstituted 1,2,4-triazole is synthesized from thiosemicarbazide and formic acid, followed by oxidation with nitric acid or hydrogen peroxide. The Einhorn-Brunner and Pellizzari reactions are also used for its synthesis.
*Including some distributors, etc.
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Alzchem Group AG, originally founded in 1908, is a specialty chemicals supplier with sites in Trostberg, Schalchen, Hart and Waldkraiburg, located in Germany. The company's products are linked to relevant social developments such as sustainability, climate protection, healthy aging, and securing the world’s food supply. They form a production network that conserves resources, saves energy, reduces emissions, transport costs and uses the synergies of an integrated infrastructure. They produce at a total of four sites in the Southeast Bavarian chemical triangle and at the site in Sundsvall (Sweden), with sales companies in Atlanta (USA), Shanghai (China) and Coventry (England).
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
City Chemical LLC. was founded in 1997 and is a manufacturer and supplier of chemical products based in West Haven, Connecticut, United States. The company's product portofolio includes ammonium fluoride, silicon acetate, potassium manganate, silicon bromide, and barium cyanide. The products are used in various industries such as military, aerospace, semiconductor, and research and development. The MOCVD, CVD, and ALD products lineup are used in the semiconductor sectors for producing micro and nano electronics thin films.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
Hangzhou Dayangchem Co.Limited is a manufacturer and supplier of fine chemicals and pharmaceutical intermediates, headquartered in Hangzhou, Zhejiang, China. Its product range covers organic compounds, Active Pharmaceutical Ingredients (APIs), nutritional products, and custom synthesis. Some of its products are heterocyclic compounds, aromatic compounds, boronic acids, amino acids, and organometallic compounds. These products are used for developing various drugs, agrochemicals, dyes, flavors, and fragrances for different markets such as pharmaceutical, biotechnology, cosmetic, and food industries. The company holds ISO 9001:2008 certification for its quality management system.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Otsuka Chemical Co., Ltd., was established in 1950 and is headquartered in Osaka, Japan as a manufacturer of inorganic salts among other products. The company offers an extensive and diversified product portfolio including blended foaming agents, polymerization initiators, potassium titanate filler, advanced rubber additives, aromatic chemicals, and more. These products are integral to various industries including the automotive sector as capacitor electrolysis solutions for electric components, electronic devices as a detergent for semiconductor-related components, residential use as a fire retardant for printed boards, and medical use as synthetic raw materials.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Henan Tianfu Chemical Co., Ltd., founded in 2009, is a Chinese chemical manufacturer and supplier based in Zhengzhou, Henan. The company has developed over 500 compounds, mostly for fine applications in manufacturing and life science. Their product range includes electronic chemicals, ultraviolet (UV)-curing materials, ionic liquids, and pharmaceutical materials. Additionally, Henan Tianfu has expanded into the fine chemical market, offering noble metal catalysts, organic phosphine ligands, and organic light-emitting diode (OLED) intermediates. They are also involved in the development of pesticides and medical intermediates, as well as the analysis and synthesis of electronic chemical materials.
Avantor was founded in 1904 and is headquartered in Radnor, Pennsylvania, as a supplier of lab and production services such as general and technical lab services, production, and business process consulting services. The company offers various clinical services, including customized kitting solutions, clinical trial equipment, and ancillary services. The organization is regarded as a dependable global partner for customers and suppliers in the life sciences, advanced technologies, and applied materials industries, spanning from initial discovery to final delivery.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Johoku Chemical, established in 1958 and headquartered in Tokyo, Japan, is a manufacturer and supplier of fine chemical products. The company offers over 150 products, including phosphites, acid phosphates, and benzotriazole compounds. Its products are generally used in various industries as a lubricating oil additive and corrosion inhibitor for several materials like copper, zinc, and as a raw material for medicinal intermediates. The company operates in compliance with ISO 9001 quality management guidelines.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Hunan Huateng Pharmaceutical Co. Ltd., established in 2013 and based in Changsha, China, is a supplier of PEG derivatives and a contract manufacturer of APIs and intermediates. It stocks chemical reagents, vaccine excipients, APIs, and pharmaceutical intermediates, among other chemicals. In 2016, the company launched the first R&D center in Changsha, and in 2020, it completed the construction of its company, which started operations. It is ISO 9001 certified and has a range of facilities to manufacture and store chemical products up to 10 Metric Tons.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Watson International Limited, founded in 1996, and headquartered in London, England, is a professional fine chemical supplier. The company is capable in the development of both natural and unnatural amino acids, along with amino alcohols. Additionally, it offers custom synthesis services for carbohydrates, including carbohydrate-based intermediates, carbohydrate-based drugs, and glycosidase substrates. As the business department of the FCAD Group, the company serves as a crucial intermediary between research and development (R&D), production, and market demand. Leveraging the research and development capacity of FCAD, it caters to several industries, including pharmaceuticals, healthcare, electronics, and personal care.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | AlzChem, LLC |
21.4%
|
| 2 | Johoku Chemical |
14.3%
|
| 3 | Otsuka Chemical Co.,Ltd. |
14.3%
|
| 4 | City Chemical LLC. |
7.1%
|
| 5 | Matrix Fine Chemicals GmbH |
7.1%
|
| 6 | Jigs chemical |
7.1%
|
| 7 | Avantor |
7.1%
|
| 8 | Carl Roth GmbH + Co. KG |
7.1%
|
| 9 | MilliporeSigma |
7.1%
|
| 10 | Merck |
7.1%
|
Derivation Method
The ranking is calculated based on the click share within the triazole page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 25.0% |
|
United States of America
|
3 | 15.0% |
|
China
|
3 | 15.0% |
|
India
|
3 | 15.0% |
|
Germany
|
2 | 10.0% |
|
United Kingdom
|
2 | 10.0% |
|
Switzerland
|
2 | 10.0% |
