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This section provides an overview for tetralin as well as their applications and principles. Also, please take a look at the list of 14 tetralin manufacturers and their company rankings. Here are the top-ranked tetralin companies as of December, 2024: 1.LobaChemie Pct.Ltd., 2.KANTO CHEMICAL CO.,INC., 3.Manchester Organics Ltd..
Table of Contents
Figure 1. Basic information on tetralin
Tetralin, also known as 1,2,3,4-tetrahydronaphthalene, is an alicyclic compound. It appears as a colorless liquid and is characterized by its hybrid structure, where one benzene ring of naphthalene is hydrogenated and saturated, while the other remains a benzene ring. This gives it both aliphatic and aromatic properties.
Tetralin is primarily used as a solvent in various applications, including for paints, fats, oils, resins, rubber, waxes, and adhesives. Its high penetrating power makes it effective for cleaning machine parts, particularly in removing oils and fats from intricate details where ordinary solvents are less effective.
It also finds use as a reaction solvent in pharmaceutical intermediate production and decalin synthesis through hydrogenation. Additionally, tetralin reacts with bromine to produce hydrogen bromide, a process utilized in laboratory settings.
Tetralin is insoluble in water but soluble in organic solvents such as ethanol, ether, and benzene. Its physical properties include a melting point of -35.8°C, a boiling point of 206-208°C, a flash point of 77°C, and an ignition point of 385°C. Oxidation of tetralin leads to the formation of phthalic anhydride, while dehydrogenation results in naphthalene. It is prone to oxidation by air, producing explosive tetralin hydroperoxide, which necessitates caution during distillation, especially in aged samples.
The chemical formula of tetralin is C10H12, with a molar mass of 132.2 g/mol and a density of 0.970 g/cm3. Structurally, it resembles naphthalene but with one hydrogenated and saturated ring, contributing to its aromatic hydrocarbon nature.
Figure 2. Synthesis of tetralin
Tetralin can be synthesized via nickel-catalyzed hydrogenation of naphthalene or through the Clemmensen reduction of α-tetralone using a zinc amalgam and hydrochloric acid. The classical Darzens tetralin synthesis involves the cyclization of 4-aryl-1-pentene with sulfuric acid to produce methyl tetralin derivatives.
Figure 3. Synthesis of tetralin by Bergmann cyclization
The Masamune-Bergman cyclization, a rearrangement reaction activated by heating enediyne in the presence of a hydrogen donor, is another method for synthesizing the tetralin moiety. The reaction produces a reactive p-benzyne biradical, which can react with various hydrogen donors. For instance, the reaction with carbon tetrachloride yields 1,4-dichlorobenzene, while methanol produces benzyl alcohol. Due to greater ring strain, this cyclization can also occur at lower temperatures, below 37°C, when using larger hydrocarbon rings like cyclodec-3-ene-1,5-diyne.
*Including some distributors, etc.
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MedKoo Biosciences, Inc. is an American manufacturer of biochemical reagents established in 2009 and based in Morrisville, North Carolina. Specializing in small molecule drugs for laboratory use, the company offers a wide range of products including apoptosis inducers, anticancer reagents, epigenetic modulators, and various pharmaceutical related chemicals. These have applications in various fields including microbiology, stem cell research, endocrinology, and epigenetics. MedKoo Biosciences also provides R&D services to client biotechnology, biomedical, and pharmaceutical companies, as well as academic institutions.
Restek Corporation is a chromatography products manufacturer founded in 1985 and headquartered in Bellefonte, Pennsylvania. The company offers various products including sample preparation and collection products like solid phase extraction (SPE) cartridges, liquid chromatography (LC) and supercritical fluid chromatography (SFC) columns, and reference standards used for calibration and quality control purposes. Other products include accessories such as flow meters, regulators, and valves. These are used for monitoring the quality of soil, air, and water, as well as petrochemicals and pharmaceuticals. Restek Corporation provides clients with tech support, product education, and custom solution services.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Manchester Organics Ltd., established in 1996 and headquartered in Cheshire, England, is a manufacturer of organic building blocks, intermediates & research chemicals. The company offers over 50,000 building blocks and fine organic chemicals. It specializes in fluorination technology and general organic synthesis at all scales and provides a chemically diverse range of custom synthesis services, development and scale-up projects. The company has multiple milligram to multi-kilo production facilities with high pressure capability and cGMP specialist fluorination facility.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
OÜ Liprafarm, founded in 2007, and based in Tallinn, Estonia, operates as a supplier and a distributor of chemical products tailored for experimental purposes. Its specialization is in the development and sale of different Natural Science kits for practical experiments. Its product catalog encompasses a range of chemicals, including Potassium Iodate, Acetic Anhydride, Bromothymol Blue, as well as 2-Methoxyethanol, and Allyl Bromide, which find applications in chemical experiments and organic synthesis.
Ataman Kimya, established in 2006, is a distributor of chemicals based in Istanbul, Turkey. Their wide range of products includes detergents, cosmetics, disinfectants, pharmaceutical chemicals, and water treatment chemicals. They also offer textile, leather, paper, and mining chemicals. These chemicals, such as hydrogenated castor oils, ethanol, and butylene glycol, find applications in various industries, such as personal care, household cleaning, fragrance, coatings, and agriculture. The company also offers custom blending to meet specific requirements.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | LobaChemie Pct.Ltd. |
28.9%
|
| 2 | KANTO CHEMICAL CO.,INC. |
15.6%
|
| 3 | Manchester Organics Ltd. |
13.3%
|
| 4 | ATAMAN Kimya A.S. INC. |
6.7%
|
| 5 | Junsei Chemical Co.,Ltd. |
6.7%
|
| 6 | OÜ Liprafarm |
4.4%
|
| 7 | Biosynth |
4.4%
|
| 8 | Kishida Chemical Co.,Ltd. |
4.4%
|
| 9 | Merck |
4.4%
|
| 10 | MedKoo Biosciences, Inc. |
2.2%
|
Derivation Method
The ranking is calculated based on the click share within the tetralin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 36.4% |
|
United States of America
|
2 | 18.2% |
|
India
|
2 | 18.2% |
|
United Kingdom
|
1 | 9.1% |
|
Switzerland
|
1 | 9.1% |
| Estonia | 1 | 9.1% |
