This section provides an overview for sulfonamides as well as their applications and principles. Also, please take a look at the list of 5 sulfonamide manufacturers and their company rankings. Here are the top-ranked sulfonamide companies as of November, 2024: 1.Stratechem (I) Pvt. Ltd., 2.Manus Aktteva Biopharma LLP, 3.LGC Standards.
Table of Contents
Sulfonamides are derivatives of alkyl sulfonic acid, synthesized through the reaction of sulfuryl chloride with ammonia or amine, characterized by the chemical structure R-SO2-NR'R". These compounds are notable for their stability against hydrolysis and hydride reduction, making them more resistant than carboxylic acid amides. They exist as aliphatic or aromatic types, depending on their carbon structure.
Sulfonamides find varied applications from serving as antibacterial agents in sulfa drugs to being used in artificial sweeteners like saccharin and plasticizers such as p-toluenesulfonamide. They work by inhibiting folic acid synthesis in microorganisms, effectively combating a range of bacteria, fungi, and certain parasites.
Typically appearing as a white to light yellow crystalline powder, sulfonamides are stable, have high melting points, and decompose to release ammonia when heated. They are soluble in water and several organic solvents, with their aqueous solutions being slightly acidic.
Microorganisms can develop resistance to sulfonamides due to mutations in the folate biosynthetic enzyme, reducing the efficacy of these drugs.
Orally or topically administered sulfonamides are rapidly absorbed and distributed, metabolized in the liver, and excreted through the kidneys.
Usage during pregnancy or lactation is advised only if the benefits outweigh the risks, with special caution near delivery due to potential risks of neonatal and nuclear jaundice. Sulfonamides should be avoided by those with allergies to sulfonamide drugs, porphyria, and can cause side effects including hypersensitivity reactions and crystalluria, which may be mitigated by adequate hydration.
The sulfanilamide structure forms the backbone for various drugs, including thiazide diuretics and sulfonylurea diabetes medications. Those allergic to sulfonamides may also react to these classes of drugs.
*Including some distributors, etc.
Sort by Features
Sort by Area
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Stratechem (I) Pvt. Ltd., founded in India in 1976, is a manufacturer of pure aromatic like Mentha Arvensis Oil, Menthol Crystals, and Mentha Piperita Oil. The company's product range includes an array of natural isolates and essential oils, Citral Ex Lemongrass, Natural Patchouli Oil, Rose Indian Oil, and Tea Tree Oil. The company has SO 22000:2005, ISO 9001:2008, HACCP, GMP certifications for Food and Pharma, and Kosher Certifications and serves markets such as cosmetic and personal care, food and beverage and pharmaceutical.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
TCI America is based in Portland, Oregon, USA, and is a manufacturer and distributor of organic chemicals that was incorporated as the U.S. subsidiary of Tokyo Chemical Industry Co. Ltd. in 1985. The company specializes in producing organic chemicals used for research and development purposes. These include polymer additives, organic synthesis reagents, and chromatography columns. The company also offers contract research, bulk production, and custom synthesis services for clients in research institutions, or for production facilities with unique project specifications.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Stratechem (I) Pvt. Ltd. |
55.6%
|
2 | Manus Aktteva Biopharma LLP |
22.2%
|
3 | LGC Standards |
11.1%
|
4 | TCI America |
11.1%
|
Derivation Method
The ranking is calculated based on the click share within the sulfonamide page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 2 | 66.7% |
United Kingdom | 1 | 33.3% |