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This section provides an overview for diazoniums as well as their applications and principles. Also, please take a look at the list of 9 diazonium manufacturers and their company rankings. Here are the top-ranked diazonium companies as of April, 2025: 1.Toronto Research Chemicals, 2.VulcanChem, 3.BenchChem.
Table of Contents
Diazonium refers to nitrogen compounds characterized by an NN triple bond, making them highly reactive and often unstable. These compounds typically exist as diazonium salts due to their monovalent cationic nature. Owing to their inherent explosiveness, diazonium compounds are usually utilized in solution within reaction systems, without isolation.
Stabilization of diazonium compounds can be achieved by using aryl groups with electron-withdrawing groups as substrates and anions like tetrafluoroborate (BF3). A commercially available example is p-Morpholinobenzenediazonium Tetrafluoroborate.
Diazonium compounds, due to their reactive NN triple bond, primarily serve as intermediates in various chemical reactions. Key reactions involving diazo groups include aromatic substitution reactions like the Sandmeyer reaction and diazo coupling.
These reactions are crucial in the synthesis of pharmaceuticals, functional materials, and azo dyes. Azo dyes, which constitute over half of all synthetic dyes, are produced through coupling reactions between diazonium compounds and phenols or aromatic amines. The significance of diazonium compounds, especially in the industrial production of azo dyes, underscores their importance in the field of chemical synthesis.
*Including some distributors, etc.
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VulcanChem is a supplier of research chemicals and biochemical products, located in California, United States, founded in 2017. The company specializes in providing a wide range of compounds such as inhibitors, peptides, APls, impurities, natural products, and signature products to the research and pharmaceutical industries. It offers an extensive catalog of chemicals used in various scientific disciplines, including life sciences and drug discovery. It provides compounds to research institutions and pharmaceutical companies seeking chemical solutions for scientific endeavors.
BenchChem, an American company located in Pasadena, California, is a supplier specializing in chemicals and biochemicals for laboratory and research and development use. The company’s product portfolio includes inhibitors, chemical reagents, bioactive chemicals, lead compounds, and catalysts. These products cater to various industries, including pharmaceutical companies, biotechnology firms, academic and research institutions, chemical and materials science researchers, as well as environmental and analytical laboratories. The company provides customer services, including contract manufacturing and analytical services.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SAGECHEM, founded in 2009 and located in Hangzhou, China, is a manufacturer and distributor of chemical R&D. The company’s broad range of products includes aminopeptides, APIs and intermediates, carbohydrates, ionic liquids, and organosilicon. These products play essential roles in pharmaceutical research, drug development, and biotechnology for creating therapeutic compounds and biopharmaceuticals. These chemicals are employed in chemical R&D to explore new materials, chemical reactions, and advanced materials in materials science. The company’s chemicals cater to industries such as agriculture, environmental science, and energy-related research and are used in an array of scientific and industrial settings.
Hefei TNJ Chemical Industry Co., Ltd., founded in 2001, is a chemical manufacturer and supplier in Hefei, Anhui, China. The company has a diverse product portfolio comprising over 60 key products spanning the Chemicals, Food, Pharmaceutical, and Personal Care sectors. Notable products include sophthalic acid, polylysine, as well as chlorin, and potassium acetate. To ensure product quality, the company maintains a robust quality management system that aligns with ISO 9001:2015 standards.
Ranking as of April 2025
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Toronto Research Chemicals |
33.3%
|
| 2 | VulcanChem |
16.7%
|
| 3 | BenchChem |
16.7%
|
| 4 | CYMIT QUÍMICA S.L. |
16.7%
|
| 5 | MilliporeSigma |
16.7%
|
Derivation Method
The ranking is calculated based on the click share within the diazonium page as of April 2025. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 28.6% |
|
China
|
2 | 28.6% |
|
Switzerland
|
1 | 14.3% |
|
Canada
|
1 | 14.3% |
|
Spain
|
1 | 14.3% |
