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This section provides an overview for sarcosine as well as their applications and principles. Also, please take a look at the list of 12 sarcosine manufacturers and their company rankings. Here are the top-ranked sarcosine companies as of December, 2024: 1.Shaanxi Pioneer Biotech Co., Ltd..
Table of Contents
Sarcosine is a naturally occurring amino acid.
Its IUPAC name is 2-(Methylamino) acetic acid, and it is also known as N-Methylglycine, Methylglycine, Sarcosinic acid), also called sarcosinic acid. Abbreviated as Sar.
Sarcosine has been widely used as a raw material for toothpaste and biodegradable surfactants. For example, the sodium salt of lauroyl sarcosine, which has lauric acid added to the nitrogen, is a surfactant with low skin irritation, excellent cleaning power even with hard water, and good foaming properties. Because of these excellent cleaning effects, it is often used in shampoos, body soaps, facial cleansers, toothpastes, and other products.
Recent studies have shown that sarcosine is likely to be a biomarker for prostate cancer and that it is effective in treating psychiatric disorders such as depression and schizophrenia. Polysarcosine, a polymer of sarcosine, is also being investigated for use in DDS (drug delivery system) formulations.
The chemical formula is C3H7NO2 and the molecular weight is 89.09. The CAS number is 107-97-1. Sarcosine decomposes at 208°C and is a white crystalline powder solid at room temperature. It is odorless, sweet-tasting, and deliquescent. It is soluble in water and less soluble in ethanol. The pH, which indicates the degree of acidity or alkalinity, is 7.4 (at 5.6 μg/mL dissolved). Under neutral conditions, carbo anions and ammonium ions are formed and exist as zwitterions.
Sarcosine is a natural amino acid found in muscle and other body tissues. In foods, it is found in egg yolks, legumes, ham, etc. Also called N-methylglycine (NMG), it is formed when choline is metabolized and then broken down into glycine by the enzyme sarcosine dehydrogenase.
Sarcosine can be produced industrially by Strecker amino acid synthesis. Strecker amino acid synthesis is a method to synthesize amino acids from aldehyde, ammonia, and hydrogen cyanide. Aldehydes and ammonia first react to form imine, and then aminonitrile is formed by nucleophilic attack of cyanide ions on the imine. Subsequent hydrolysis allows the desired amino acid to be synthesized. The final step of hydrolysis usually proceeds by post-treatment with hydrochloric acid. It can also be synthesized by nucleophilic substitution reaction of chloroaminoacetic acid and methylamine.
Handling Precautions
Strong oxidizing agents are incompatible with sarcosine. Avoid contact when handling and storing. When handling, be sure to wear protective clothing with long sleeves, protective gloves, and protective glasses, and use in a draft chamber.
In the case of Fire
When burning, the product may decompose to produce toxic gases such as carbon monoxide (CO), carbon dioxide (CO2), and nitrogen oxides (NOx). In case of fire, use carbon dioxide (CO2), powder, water spray, foam, or fire sand to extinguish the fire. There are no specific fire extinguishing agents prohibited for use.
Storage
Store in a cool, well-ventilated place out of direct sunlight in a sealed glass container.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Shaanxi Pioneer Biotech Co., Ltd., founded in China in 2012, is a HACCP-certified food ingredients manufacturer. The company's product portfolio includes a range of food ingredients, such as preservatives, emulsifiers, flavor enhancers, and more. Its products are used to enhance the taste and texture of snacks, candies, and confectionery items and the development of nutritional and dietary supplements. The company has sales channels in China, the USA, and EU countries and works with brands such as Nestle, Coca Cola, and Pepsi.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
naugraexport was established in 1951 and is a distributor and supplier of lab equipments based in Ambala Cantt, Haryana, India. The company's product portofolio offers various products such as zoom stereo binocular microscope, human anatomy models, flask erlenmeyer narrow neck glass, laser theodolite, and precision engineered cube mould. The products are used in various industries such as petrochemical, agriculture, semiconductor manufacture, pharmaceutical, and energy. The company has obtained the certificate of ISO 9001:2008 certification standards.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Shaanxi Pioneer Biotech Co., Ltd. |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the sarcosine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
4 | 57.1% |
|
Japan
|
3 | 42.9% |
