28 Quinuclidine Manufacturers in 2024
This section provides an overview for quinuclidines as well as their applications and principles. Also, please take a look at the list of 28 quinuclidine manufacturers and their company rankings. Here are the top-ranked quinuclidine companies as of April, 2024: 1.Combi-Blocks Inc., 2.MilliporeSigma.
Table of Contents
What Is Quinuclidine?
Quinuclidine is a heterocyclic amine with the chemical formula C7H13N. It is also known as 1,4-ethanopiperidine. Its molecular weight is 111.18, CAS number is 100-76-5, density is 1.025 g/cm3, and melting point is 158°C (316°F).
Its IUPAC name is 1-azabicyclo[2.2.2]octane. It is a sublimable, colorless to milky solid. As a natural product, quinuclidine is categorized as an alkaloid, prominently featured in the molecular structure of quinine, a well-known anti-malarial alkaloid.
Uses of Quinuclidines
1. Starting Material
Quinuclidine serves as a foundational material for pharmaceuticals and functional materials, embodying many natural products that incorporate the quinuclidine structure. A prime example is quinine, celebrated for its anti-malarial properties.
Quinine, commonly administered as quinine hydrochloride or quinine sulfate to enhance solubility in water, exhibits specific toxicity towards Plasmodium falciparum. This parasite metabolizes hemoglobin in erythrocytes for nutrition. However, the resultant heme is toxic to the parasite, which it counteracts by polymerizing heme into a nontoxic form using heme polymerase. Quinine's anti-malarial action is theorized to stem from its inhibition of heme polymerase.
Beyond quinine, numerous natural products featuring the quinuclidine structure exhibit diverse bioactivities. Recent years have seen significant interest in their asymmetric synthesis, with quinuclidine utilized as a key starting material.
2. Catalyst
Quinuclidine's strong nucleophilic properties make it a valuable catalyst in chemical reactions, such as the addition of alkenes to aldehydes in the Morita-Baylis-Hillman reaction. The potential for functionalization to introduce a chiral point into compounds underscores its significance in the development of asymmetric synthetic catalysts.
Properties of Quinuclidines
1. Physical Properties
The [2.2.2]bicyclooctane ring endows quinuclidine with distinctive physical properties, enhancing its solubility compared to conventional amine compounds due to its unique structure.
2. Chemical Properties
Quinuclidine exhibits unique chemical behaviors not common to typical amides, including increased reactivity due to its steric structure. This structure limits electron pair conjugation with the pi orbitals of carbonyl carbon and oxygen, rendering the carbonyl carbon more susceptible to nucleophilic attack. Its pronounced nucleophilicity can be attributed to the fixed position of the non-covalent electron pair by the ring structure and the minimal steric hindrance around the nitrogen atom.
Other Information on Quinuclidines
Hazards of Quinuclidines
Despite its acute toxicity and potential to cause skin and eye irritation, quinuclidine is not subject to regulation under major safety and health legislations. Its handling requires careful consideration of its hazardous properties.
List of 28 Quinuclidine Manufacturers
*Including some distributors, etc.
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ChemScence
Quinuclidine
Manufacturer Overview
ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
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AK Scientific, Inc
Quinuclidine hydrochloride
Manufacturer Overview
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
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Spectrum Chemical Mfg. Corp.
Quinuclidine
Manufacturer Overview
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
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American Elements
Quinuclidine-4-carbonitrile
Manufacturer Overview
American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
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Alfa Chemistry
Quinuclidine
Manufacturer Overview
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
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Santa Cruz Biotechnology, Inc.
Quinuclidine
Company Overview
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
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Ambeed
Quinuclidines
Company Overview
Ambeed, established in 2015 and headquartered in Arlington Heights, Illinois, is a manufacturer and supplier of catalog products, including inhibitors, natural products, nucleotides, building blocks, and amino acids. The company mainly specializes in organoboron, metal catalysts, heterocyclic building blocks, and materials science-related products. Its catalog has more than 100,000 in-stock products, increasing monthly. As of 2019, the company’s R&D center had developed five product lines with over 600,000 products. The company provides pre-sale and after-sale services and works with distributors from several countries, including India, Pakistan, Egypt, Poland, and Brazil.
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Thermo Fisher Scientific Inc.
Quinuclidine
Company Overview
Thermo Fisher Scientific Inc., founded in 1956 and headquartered in Waltham, Massachusetts, is a manufacturer and supplier of life science solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services. Through its brand names, including Invitrogen, Fisher Scientific, Patheon, Applied Biosystems, and Gibco, among others, the company provides a wide range of products, which include chromatography systems, thermal cyclers, automated cell counters, fermenters, and DNA polymerases. The company’s annual revenue is over 40 billion USD, and it serves several fields, including customers working in clinical diagnostic labs, research institutions, hospitals, government agencies, and pharmaceutical/biotech companies.
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BenchChem
Quinuclidine-3-carboxylic acid
Distributor Overview
BenchChem, an American company located in Pasadena, California, is a supplier specializing in chemicals and biochemicals for laboratory and research and development use. The company’s product portfolio includes inhibitors, chemical reagents, bioactive chemicals, lead compounds, and catalysts. These products cater to various industries, including pharmaceutical companies, biotechnology firms, academic and research institutions, chemical and materials science researchers, as well as environmental and analytical laboratories. The company provides customer services, including contract manufacturing and analytical services.
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Advanced ChemBlocks Inc
Quinuclidine
Distributor Overview
Advanced ChemBlocks Inc. 2010 in San Francisco Bay, USA, is a supplier of building blocks, bioreference products and synthesized molecules. It supplies over 80,000 chemical products such as azetidine, bicyclic ring, cyclobutane, and indazole. The company also provides custom synthesis services for contaminants, reference compounds, small molecules, pharmaceutical metabolites, and fine chemicals. Besides that, it offers scale-up and manufacturing services such as developing new APIs and intermediates and optimizing synthetic routes.
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LGC Standards
Ethyl Quinuclidine-4-carboxylate
Manufacturer Overview
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
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Key Organics Ltd
Ethyl quinuclidine-4-carboxylate
Manufacturer Overview
Key Organics Ltd, founded in 1973 and headquartered in Cypress, USA, is a manufacturer of chemical products for the pharmaceutical, agrochemical and biotechnology industries. The company is an international CRO specializing in synthetic organic chemistry, providing chemistry and analytical services, as well as BIONET products for the global Life Science industries. Its BIONET portfolio consists of over 300,000 intermediates, fragments, biochemicals, and building blocks, available in ex-stock and in >95% purity with same day dispatch. The company offers bespoke chemistry solutions, from the custom synthesis of a single compound to multiple and long-term FTE projects.
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Manchester Organics Ltd.
Quinuclidine-4-carbonitrile
Manufacturer Overview
Manchester Organics Ltd., established in 1996 and headquartered in Cheshire, England, is a manufacturer of organic building blocks, intermediates & research chemicals. The company offers over 50,000 building blocks and fine organic chemicals. It specializes in fluorination technology and general organic synthesis at all scales and provides a chemically diverse range of custom synthesis services, development and scale-up projects. The company has multiple milligram to multi-kilo production facilities with high pressure capability and cGMP specialist fluorination facility.
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Manufacturer Overview
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
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Pharmaffiliates
Quinuclidine
Manufacturer Overview
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
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Tokyo Chemical Industry Co., Ltd.
Quinuclidine
Manufacturer Overview
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
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Merck
Quinuclidine
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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Manufacturer Overview
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
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MilliporeSigma
Quinuclidine
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Alfa Aesar, Thermo Fisher Scientific.
Quinuclidine
Company Overview
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
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KOEI CHEMICAL CO., LTD.
Quinuclidine
Company Overview
KOEI CHEMICAL CO. LTD. established in 1917 and based in Tokyo, Japan, is a manufacturer and supplier specializing in the production of chemical products. The company's product portfolio includes ionic liquids, amines, formalin products, pyridines, and pyrazines. These chemicals are utilized in various sectors, including pharmaceuticals, agricultural chemicals, electronics, furniture manufacturing, and the paint and coatings industry. The company is ISO 9001 and ISO 14001 certified, and provides custom synthesis and technical support to its clients.
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Combi-Blocks Inc.
Quinuclidine-2-carboxylic acid
Company Overview
Combi-Blocks Inc., established in 1997 and headquartered in San Diego, California, USA, is a research-driven manufacturer and global supplier of laboratory reagents. The company specializes in the research, development, and distribution of combinatorial building blocks, organic compounds, and fine chemicals, making them a pivotal player in providing essential materials for scientific research and chemical synthesis worldwide. Its diverse product range encompasses boronic acids, imidazoles, indoles, oxindoles, and nitrobenzenes. These offerings find applications across pharmaceuticals, biotechnology, and various chemical industries.
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Lab Pro Inc.
Quinuclidine Hydrochloride
Company Overview
Lab Pro Inc. (LP) is an American manufacturer and distributor of laboratory equipment and supplies that was established in Sunnyvale, California in 1979. The company produces various chemical products including reagents, oxidizers, and acids, as well as personal protective equipment (PPE), microscopes, and laboratory hand tools. It also offers laboratory instrumentation and utensils such as refractometers, forceps, and pH meters. Aside from its products, LP also provides vendor-managed inventory and lab chiller leasing services for its clients in industrial research facilities, academic institutions, and R&D testing laboratories.
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VWR International, LLC.
Quinuclidine
Company Overview
VWR International, LLC., established in 1852 and based in Pennsylvania, United States of America, is a manufacturer of laboratory products. The company produces products such as abrasion testers, Chromatography detectors, earmuffs, and face shields and supplies to different industries such as industrial, education, government, biotechnology, and pharmaceutical. The ISO standards for environment, quality, health, and safety make sure that all its products are tested for quality and are environment safe. The company has manufacturing, distribution, and customer service resources to supply the products to 4000 suppliers worldwide.
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SEQENS
Hydroxy quinuclidine
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AbovChem
Quinuclidine-4-carboxylic acid
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Otto Chemie Pvt. Ltd
Quinuclidine
Distributor Overview
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
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Quinuclidine Manufacturer Ranking
*Including some distributors, etc.Ranking as of April 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
66.7%
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| 2 | Combi-Blocks Inc. |
33.3%
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Derivation Method
The ranking is calculated based on the click share within the quinuclidine page as of April 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- SEQENS: 3,200
- KOEI CHEMICAL CO., LTD.: 409
Newly Established Company
- BLDpharm: 2014 (10 years ago)
- Advanced ChemBlocks Inc: 2010 (14 years ago)
- Pharmaffiliates: 2001 (23 years ago)
Company with a History
- Tokyo Chemical Industry Co., Ltd.: 1946 (78 years ago)
- Biosynth: 1966 (58 years ago)
- Spectrum Chemical Mfg. Corp.: 1971 (53 years ago)
Quinuclidine Manufacturers in United States
*Including some distributors, etc.
- ChemScence
- AK Scientific, Inc
- Spectrum Chemical Mfg. Corp.
- American Elements
- Alfa Chemistry
- Santa Cruz Biotechnology, Inc.
- Ambeed
- Thermo Fisher Scientific Inc.
- BenchChem
- Advanced ChemBlocks Inc
Global Distribution of Quinuclidine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
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10 | 50.0% |
United Kingdom
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4 | 20.0% |
India
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2 | 10.0% |
Japan
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2 | 10.0% |
Switzerland
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1 | 5.0% |
Spain
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1 | 5.0% |
