All Categories
History
This section provides an overview for cadaverine as well as their applications and principles. Also, please take a look at the list of 9 cadaverine manufacturers and their company rankings. Here are the top-ranked cadaverine companies as of December, 2024: 1.MilliporeSigma, 2.Merck, 3.Stanford Advanced Materials.
Table of Contents
Cadaverine is a diamine and a component of the toxic substance ptomaine, produced by the putrefaction of proteins. Its IUPAC name is pentane-1,5-diamine, and it is also known as 1,5-diaminopentane, 1,5-pentadiamine, or pentamethylenediamine. The name cadaverine is derived from the English word "cadaverous," reflecting its association with the odor of decomposition. While cadaverine contributes to the characteristic smell of decaying matter and semen, and is known as a causative agent of bad breath, it does not participate in the decomposition process itself.
Cadaverine serves various functions in the body, similar to other polyamines. It acts as a growth factor essential for cell division and is thought to promote the synthesis of nucleic acids and proteins, including RNA. This can stimulate metabolism, help prevent aging, and guard against arteriosclerosis. Additionally, cadaverine, along with histamine and other non-volatile amines produced by decomposition, is implicated in histamine food poisoning. It can enhance the effects of histamine by inhibiting detoxification enzymes and promoting histamine absorption in the intestine. High levels of cadaverine have also been detected in the urine of patients with abnormal lysine metabolism, and it is associated with malodor in conditions such as bacterial vaginosis.
Industrially, cadaverine is utilized as a monomer in the synthesis of polyamides, including nylon, highlighting its significance beyond biological contexts.
With the chemical formula C5H14N2 and a molecular weight of 102.18, cadaverine is identified by the CAS number 462-94-2. It is a clear, colorless liquid at room temperature, with a melting point of 9°C (48.2°F), a boiling point of 179°C (354.2°F), and a specific, pungent odor. Cadaverine is soluble in water and ethanol, and slightly soluble in diethyl ether. It exhibits strong basicity, demonstrated by its acid dissociation constants, indicating its chemical reactivity.
Cadaverine can be produced through the decarboxylation of lysine, using various methods including the use of 1,5-dichloropentane, glutardinitrile, or glutaraldehyde as starting materials. This process can occur naturally or synthetically, emphasizing the versatility of cadaverine's production methods.
Due to its properties, cadaverine is subject to regulation under various national laws and regulations, reflecting the need for careful handling and storage to mitigate its potential hazards.
Appropriate safety measures, including the use of personal protective equipment and adherence to storage recommendations, are crucial when dealing with cadaverine, to prevent accidents and health risks.
*Including some distributors, etc.
Sort by Features
Sort by Area
Stanford Advanced Materials was established in 1994 in Lake Forest, California to provide rare-earth products for research and development purposes. Stanford Advanced Materials serves many industries ranging from automotive to fashion to energy to research to sports to textiles. Stanford Advanced Materials manufactures and distributes purified metals, ceramics, composite materials including strips, plates, rods, wires, and bars, as well as laboratory equipment and optical equipment including crystals, lenses, splitters, and windows.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Merck |
41.2%
|
| 2 | MilliporeSigma |
23.5%
|
| 3 | Stanford Advanced Materials |
11.8%
|
| 4 | Santa Cruz Biotechnology, Inc. |
11.8%
|
| 5 | Otto Chemie Pvt. Ltd |
5.9%
|
| 6 | KANTO CHEMICAL CO.,INC. |
5.9%
|
Derivation Method
The ranking is calculated based on the click share within the cadaverine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 28.6% |
|
Japan
|
2 | 28.6% |
|
India
|
2 | 28.6% |
|
United Kingdom
|
1 | 14.3% |
