All Categories
History
This section provides an overview for oxaloacetic acids as well as their applications and principles. Also, please take a look at the list of 11 oxaloacetic acid manufacturers and their company rankings. Here are the top-ranked oxaloacetic acid companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.Cayman Chemical Company, 3.Tokyo Chemical Industry Co., Ltd..
Table of Contents
Oxaloacetic acid is a low-molecular-weight biological substance with the chemical formula C4H4O5. It is an organic acid featuring a four-carbon atom chain, two carboxyl groups (COOH), and two carbonyl groups (C=O). It is also known by several names, including α-ketosuccinic acid, 2-ketosuccinic acid, 2-oxosuccinic acid, 2-ketobutanedioic acid, 2-oxobutanedioic acid, OAA, and its former name, oxalacetic acid.
In the citric acid cycle (tricarboxylic acid cycle or TCA cycle), oxaloacetic acid plays a crucial role by reacting with acetyl CoA, leading to the production of citric acid. This cycle is integral for energy generation and metabolite production. Oxaloacetic acid also serves as a necessary intermediate in amino acid metabolism and as a precursor for some amino acids.
Additionally, it is involved in glycogenesis via phosphoenolpyruvate and is the first substance produced in carbonic acid fixation in C4 plants. It is unstable at room temperature, readily converting to pyruvate upon decarboxylation.
| Chemical formula | C4H4O5 |
| English name | Oxaloacetic acid |
| Molecular weight | 132.07 |
| Melting point | 161 °C |
Oxaloacetic acid is a dicarboxylic acid containing carboxyl and ketone groups. It is acidic, with a strong acid characteristic and a relatively low pH in aqueous solutions. It is also unstable and can oxidize in air.
In the citric acid cycle, oxaloacetic acid is transformed into citric acid. It is produced by amino acid breakdown and can react with amino-containing molecules to form aspartic acid.
Oxaloacetic acid plays a vital role in cellular metabolic reactions, particularly in energy production within the citric acid cycle. It is also involved in amino acid and carbohydrate metabolism.
Oxaloacetic acid is utilized in pharmaceuticals, including hypertension and antiepileptic drugs. It has been studied for its potential in treating liver dysfunction, and kidney disease, and as an antioxidant and anticancer agent.
It is used as a catalyst in organic synthesis reactions such as alkylation and acetoacetylation.
Oxaloacetic acid is used as a food preservative, believed to be more effective than acetic acid. It also acts as a coagulation promoter for gelatin.
It enhances the taste of carbonated and sports drinks, imparting a refreshing flavor.
Handling oxaloacetic acid requires a safety and health officer experienced with hazardous materials. Refer to the SDS for safety guidelines. In case of accidental contact, wash with water and seek medical attention. Store away from fire and high temperatures in closed containers. Avoid mixing with alkaline substances to prevent heat generation. Never ingest, and avoid excessive inhalation or skin absorption. Dispose of waste appropriately.
*Including some distributors, etc.
Sort by Features
Sort by Area
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
RayBiotech Life, Inc., established in 2001 and headquartered in Peachtree Corners, Georgia, is a life sciences supplier specializing in proteomic discovery tools and disease testing methodologies. The company offers an array of protein research kits, reagents, and services for use in scientific research, including proteomics, biotechnology, and pharmaceutical development. Some of its products include cytokine arrays for protein assessment, ELISA kits for data generation, and tools for COVID-19 research. It maintains ISO 13485 medical device certification, ensuring product quality, and compliance with GLP/GMP FDA regulations.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
22.2%
|
| 2 | Cayman Chemical Company |
11.1%
|
| 3 | Tokyo Chemical Industry Co., Ltd. |
11.1%
|
| 4 | MedChemExpress |
11.1%
|
| 5 | Santa Cruz Biotechnology, Inc. |
11.1%
|
| 6 | FUJIFILM Wako Pure Chemical Corporation |
11.1%
|
| 7 | nacalai |
11.1%
|
| 8 | Merck |
11.1%
|
Derivation Method
The ranking is calculated based on the click share within the oxaloacetic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 55.6% |
|
Japan
|
4 | 44.4% |
