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This section provides an overview for acetamide as well as their applications and principles. Also, please take a look at the list of 14 acetamide manufacturers and their company rankings. Here are the top-ranked acetamide companies as of December, 2024: 1.Cefa-Cilinas Biotics Pvt. Ltd., 2.BioCrick, 3.Tokyo Chemical Industry Co., Ltd..
Table of Contents
Acetamide, an odorless white or light yellow solid (powder or crystals), is an organic compound with the chemical formula CH3CONH2.
Transitioning from solid to liquid at 81°C, acetamide serves as an excellent solvent for various organic and inorganic compounds. It finds extensive use as a solvent in organic synthesis and as a peroxide stabilizer. Given its suspected carcinogenic nature, handling acetamide necessitates suitable protective gear and a well-ventilated space.
Notable reactions involving acetamide include hydrolysis, yielding ammonia and acetic acid. It is soluble in water and ethanol, yet almost insoluble in diethyl ether.
Acetamide is designated under the Industrial Safety and Health Law as Hazardous and Noxious Substance to be Labeled and Hazardous and Noxious Substance to be Notified. Additionally, it is classified as a Class 2 Designated Chemical Substance, Class 2 - No. 1 under the PRTR Law.
Primarily, acetamide is employed as a solvent in the synthesis of organic reagents, encompassing a broad range of agents such as oxidizing and reducing agents, condensing and halogenating agents, protectants, chiral substances, and organometallic reagents.
While solid at ambient conditions, acetamide melts into a solvent above 81°C, capable of dissolving a diverse array of compounds, thereby facilitating various organic synthesis applications.
Beyond its solvent properties, acetamide functions as a stabilizer for peroxides, known for their instability and high reactivity.
Acetamide, also referred to as ethanamide or methane carboxamide, exhibits high solubility in water, methanol, ethanol, and chloroform but is insoluble in ether.
| Chemical Formula | CH3CONH2 |
| English Name | Acetamide |
| CAS No. | 60-35-5 |
| Molecular Weight | 59.07 g/mol |
| Melting Point/Freezing Point | 81°C |
| Boiling Point | 222°C |
As per the Industrial Safety and Health Law, acetamide is identified as both a Hazardous and Noxious Substance to be Labeled and Hazardous and Noxious Substance to be Notified. Under the PRTR Law, it is classified as Class 2 Designated Chemical Substance and Class 2 - No. 1.
Risks associated with acetamide include its potential as a carcinogen, eye irritant, and negative effects on fertility or fetal development. Contact with skin or eyes may cause redness and pain.
Utilizing acetamide demands thorough safety checks and the use of appropriate protective equipment in a well-ventilated area. It is advisable to wear protective gloves, clothing, safety glasses, and masks before handling. If contact occurs, wash the area with water and soap, seeking medical advice if irritation persists.
Moreover, acetamide can combust under high heat, releasing irritating and corrosive gases, necessitating temperature control during use.
Acetamide's high water solubility means it can absorb moisture from the air, which may compromise its efficacy as a solvent in organic synthesis. It is recommended to store acetamide in an inert gas-filled container in a humidity-controlled environment to maintain stability.
Given its toxicity, acetamide should not be disposed of into sewage systems. Disposal should be managed by certified waste disposal contractors, as per local regulations.
*Including some distributors, etc.
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Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Nacalai Tesque Inc. is a Japanese biotechnology company that specializes in the production and distribution of research reagents and diagnostic kits. Founded in 1958, Nacalai Tesque has grown into a globally recognized brand, serving customers in over 100 countries. The company's product portfolio includes antibodies, biochemicals, cell culture reagents, and more. Nacalai Tesque also offers contract research services for drug discovery and development. With a team of experienced professionals and state-of-the-art facilities, the company is committed to providing its customers with reliable and innovative solutions to their research needs.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Cefa-Cilinas Biotics Pvt. Ltd. |
12.5%
|
| 2 | BioCrick |
12.5%
|
| 3 | Tokyo Chemical Industry Co., Ltd. |
12.5%
|
| 4 | GLPBIO Technology LLC |
12.5%
|
| 5 | Santa Cruz Biotechnology, Inc. |
12.5%
|
| 6 | Kishida Chemical Co.,Ltd. |
12.5%
|
| 7 | FUJIFILM Wako Pure Chemical Corporation |
12.5%
|
| 8 | KANTO CHEMICAL CO.,INC. |
12.5%
|
Derivation Method
The ranking is calculated based on the click share within the acetamide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
6 | 50.0% |
|
United States of America
|
2 | 16.7% |
|
United Kingdom
|
2 | 16.7% |
|
India
|
2 | 16.7% |
