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This section provides an overview for copper chlorophyllin as well as their applications and principles. Also, please take a look at the list of 13 copper chlorophyllin manufacturers and their company rankings. Here are the top-ranked copper chlorophyllin companies as of December, 2024: 1.Nanjing NutriHerb BioTech Co.,Ltd, 2.Botanic Healthcare LLC, 3.MedChemExpress.
Table of Contents
Copper chlorophyllin, also known as copper chlorophyll, is a compound in which magnesium in chlorophyll is replaced by copper.
Copper chlorophyllin is soluble in oil but insoluble in water.
Chlorophyll, the source of copper chlorophyllin, is a natural green pigment found in plants. It gives plant leaves their green color. However, when used as a green coloring agent, chlorophyll fades over time.
Copper chlorophyllin is used as a coloring agent in place of chlorophyll. It is more stable against acid and light than natural chlorophyllin, allowing it to produce a stable green color.
Copper chlorophyllin is primarily used as a coloring agent. It is virtually insoluble in water, limiting its use in this capacity.
Water-soluble sodium copper chlorophyllin, obtained by hydrolyzing copper chlorophyllin, is used as a coloring agent in the food and cosmetic industries. Copper chlorophyllin often serves as an intermediate raw material to obtain sodium copper chlorophyllin.
Copper chlorophyllin is used as a green coloring agent in various food products. Examples of food products where sodium copper chlorophyllin is used include:
Both copper chlorophyll and sodium copper chlorophyllin are approved as designated additive colorants. Maximum amounts in each type of food product are specified.
The amount of copper chlorophyllin or sodium copper chlorophyllin is determined by the content of copper (Cu) it contains.
Copper chlorophyllin is added to cosmetics, quasi-drugs, and pharmaceuticals for green coloring. It is used in products like cleansing agents, shampoos, facial soaps, and toothpastes.
In certain quasi-drugs (medicated cosmetics), maximum amounts are specified:
Copper chlorophyllin produces a long-lasting green color. It is less susceptible to fading than natural chlorophyll due to the stability of copper (Cu) in its molecule.
Natural chlorophyllin's magnesium (Mg) is more readily released than copper (Cu), causing faster fading. Copper (Cu) is more stable in the tetrapyrrole ring of copper chlorophyllin than magnesium (Mg) in chlorophyll.
Therefore, replacing magnesium (Mg) in natural chlorophyllin with copper (Cu) forms copper chlorophyllin, stabilizing the green color.
Copper chlorophyllin's molecular structure is similar to that of chlorophyll. It has a tetrapyrrole ring and a hydrophobic long-chain alkyl structure, with copper (Cu) replacing magnesium (Mg).
Due to its hydrophobic long-chain alkyl structure, copper chlorophyllin is oil-soluble but not water-soluble. Hydrolyzing oil-soluble copper chlorophyllin makes it water-soluble. Sodium copper chlorophyllin, the salt form, is more soluble in water.
Several types of chlorophyll exist, including chlorophyll A (common in plants and algae), chlorophyll B (only in plants), and chlorophyll C1 and C2 (only in algae).
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
PubChem is a free online chemical database developed by the National Library of Medicine (NLM) at the National Institutes of Health (NIH). The company was launched in 2004 and is headquartered in Bethesda, Maryland, USA. PubChem provides a lot of information about chemicals, including chemical structures, physical properties, biological activities, safety & toxicity data, patents, and literature citations. The database can be searched by name, structure, or other identifiers. It is the world's largest collection of freely accessible chemical information, with over 150 million substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Nanjing NutriHerb BioTech Co. Ltd., founded in 2004 and based in Nanjing, China, is a certified manufacturer specializing in botanical extracts. Its product range includes natural Licorice Extract for health supplements, organic Artemisia Annua Extract used in traditional Chinese medicine, potent antioxidant astaxanthin, Milk Thistle Extract with antioxidant and anti-inflammatory properties, and water-soluble food coloring Sodium Copper Chlorophyllin. These products are certified by Kosher, HALAL, EU, and USDA organic. The company's facility holds approvals from SGS and Bureau Veritas, and it's registered with the FDA, ensuring quality and compliance with international standards.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Botanic Healthcare LLC is a manufacturer and supplier of herbal extracts and phytochemicals. It is headquartered in Pune, India, and was established in 2002. The company specializes in developing and manufacturing plant-derived active principles for complementary health medicine. Its wide range of herbal extracts includes standardized extracts, crude extracts, and essential oils. Botanic Healthcare also offers phytochemicals such as vitamins, minerals, and amino acids. The company's products are used in industries such as pharmaceuticals, cosmetics, dietary supplements, and food. Botanic Healthcare The company's devotion extends to providing quality products, transparency in ingredient sourcing, and educational resources.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Shaanxi GTL Biotech Co., Ltd., established in 2017 and headquartered in Xi'an, China, is a manufacturer and supplier of botanical extracts and manufacturer of healthcare ingredients. The company specializes in producing a wide range of extracts derived from plants, herbs, and fruits for applications in the pharmaceutical, nutraceutical, and food industries. The company's products are utilized in the development of dietary supplements, functional foods, and pharmaceutical formulations. The company also supports universities and institutions with research and development materials.
Shaanxi Yuantai Biological Technology Co., Ltd, founded in China in 2014, is a supplier of health food raw materials finished products, and functional cosmetic raw materials. The company offers a variety of health and wellness products, from dietary supplements to functional foods, and high-quality raw materials for the cosmetic industry, such as skin-enhancing ingredients formulations botanical extracts, and more. It has distribution partners in Europe, America, and Southeast Asian countries
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
30.0%
|
| 2 | MedChemExpress |
13.3%
|
| 3 | Santa Cruz Biotechnology, Inc. |
13.3%
|
| 4 | Nanjing NutriHerb BioTech Co.,Ltd |
10.0%
|
| 5 | Botanic Healthcare LLC |
10.0%
|
| 6 | nacalai |
6.7%
|
| 7 | Nutra Commerce Co., Ltd |
3.3%
|
| 8 | Shaanxi GTL Biotech Co.,Ltd |
3.3%
|
| 9 | Shaanxi Yuantai Biological Technology Co., Ltd |
3.3%
|
| 10 | PubChem |
3.3%
|
Derivation Method
The ranking is calculated based on the click share within the copper chlorophyllin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
6 | 54.5% |
|
United States of America
|
3 | 27.3% |
|
Japan
|
2 | 18.2% |
