This section provides an overview for periodic acid as well as their applications and principles. Also, please take a look at the list of 44 periodic acid manufacturers and their company rankings. Here are the top-ranked periodic acid companies as of November, 2024: 1.American Elements, 2.Ajay North America, LLC, 3.Spectrum Chemical Mfg. Corp..
Table of Contents
Periodic acid, a type of iodine oxoacid, predominantly refers to orthoperiodic acid with the chemical formula H5IO6. It also encompasses metaperiodic acid (HIO4), both sharing an oxidation number of +7 for iodine. These acids form periodates with various metals in solution, ionizing into periodate and hydrogen ions.
Primarily, periodic acid is utilized in the PAS reaction for polysaccharide detection, distinguishing between aldehydes and ketones using the Schiff reagent. This reaction decomposes polysaccharides into aldehydes, aiding in the detection of polysaccharides in organs. Additionally, periodic acid performs oxidative cleavage of diols into carbonyl compounds.
Metaperiodate sublimates at 100°C and decomposes at 138°C, forming iodic acid (HIO3) and diiodine pentoxide (I2O5). Orthoperiodate, more stable and soluble in water, melts at 122°C and decomposes around 130-140°C. It is a weak acid, with significantly lower acidity than perchloric acid.
The structure of periodic acids varies between their forms. Metaperiodic acid features a one-dimensional chain-like structure, whereas orthoperiodate forms colorless monoclinic crystals with an octahedral structure centered on the iodine atom. In solution, a variety of periodate species exist, shifting with changes in temperature and pH.
Orthoperiodic acid is synthesized through the reaction of barium hydrogen orthoperiodate with concentrated nitric acid, which upon heating, yields metaperiodic acid.
Useful for the cleavage of 1,2-bifunctional compounds, periodic acid facilitates the Malaprade reaction—cleaving vicinal diols into aldehydes or ketones, crucial for carbohydrate structural analysis. This reaction is also applicable for selective RNA labeling and as a moderate oxidant in organic synthesis, exemplified by the Babler oxidation of secondary allylic alcohols.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Ajay North America LLC, founded in 1972, is a manufacturer, supplier, and distributor of industrial chemicals. To secure a dependable source of iodine, Ajay Chemicals joint-ventured with Sociedad Química y Minera de Chile S.A. (SQM), a supplier of raw iodine. The company produces more than 70 iodine and selenium derivatives, including methyl iodide, potassium iodide, potassium iodate, calcium iodate, and many others. The Ajay-SQM Group serves a diverse range of industries, including pharmaceuticals and biotechnology, agriculture and animal feed, water treatment, and other industries that require specialty chemicals and related products.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Aceschem Inc., headquartered in Dallas, Texas, USA, is a supplier of chemical compounds, operating with research and manufacturing facilities in China. The company produces advanced pharmaceutical intermediates and fine chemicals across various quantities. Its product range includes fluorinated building blocks for pharmaceutical and agrochemical synthesis, intermediates used in compound production, research chemicals for scientific investigations, pharmaceutical intermediates as fundamental components in drug manufacturing, and fine chemicals tailored to specific requirements. It emphasizes intellectual property protection and collaboration with international biotech and pharmaceutical firms.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Hangzhou Color Powder Coating Equipment Co., Ltd., established in 2009 and located in Hangzhou, China, is a powder coating equipment manufacturer. The company offers electrostatic spray guns, high-pressure modules, circuit boards, famous gun spare parts, automatic reciprocating machines, spray booths, curing ovens, and powder coating lines. The machines efficiently spray various shapes, solving corner and recess penetration issues. These are user-friendly due to intelligent design. The company’s products are sold locally and exported to numerous countries, enjoying outstanding prestige from different clients.
Infinium Pharmachem Pvt. Ltd., established in 2003 and headquartered in Gujarat, India, is a manufacturer specializing in the development, production, and global export of Iodine Derivatives. Its derivatives find applications in pharmaceutical, chemical, biotech, and related industries worldwide. Its product range encompasses Iodine, Iodate, Iodide, and Tolune which serve as key starting materials in pharmaceutical ingredient manufacturing. The company adheres to quality and sustainability, holding certifications such as ISO-9001-2015 and ISO-14001-2015. The company plays a significant role in the supply of synthesized impurities, metabolites, intermediates, and APIs through custom synthesis.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Hangzhou Keying Chem Co., Ltd. (HKC) is a Chinese manufacturer of fine chemicals and polymers that was established in 2010. Based in Hangzhou, Zhejiang, the company offers various fine chemicals such as reagents and catalysts, as well as polymers, active pharmaceutical ingredients (APIs), and feed additives. It also produces specialty chemicals including pesticides and natural as well as synthetic dyes. HKC products are used by clients in the agricultural and industrial sectors, including Mitsubishi Chemical, Sanofi, and Dow AgroSciences.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Dns Fine Chemicals and Labs Pvt. Ltd. was founded in 2001 in Ghatkopar (W), Mumbai, India, as a manufacturer of fine chemicals and API - Active Pharma Ingredients. The company's product list encompasses iodine monochloride, methyl iodide, periodic acid, calcium iodate anhydrous, and ammonium acetate, among others. The chemicals are used as food additives, in animal feed for iodine supply, and as vital reagents in chemical synthesis. The products also serve as sources of iodine for livestock. The company serves various industries, including agriculture, pharmaceuticals, food and beverages, animal feed, chemical synthesis, laboratories, and various industrial applications.
PENTA Chemicals, established in 1990 and headquartered in Prague, Czech Republic, is a manufacturer and supplier of pure, laboratory, pharmaceutical, and special chemicals. The company offers a wide array of organic and inorganic chemicals in significant quantities, varying in quality from technical to pure, to A.G. and ACS standards. Among their products are acetaldehyde, acetamide, bromine, brilliant green, and white spirit. The company's commitment is underscored by numerous awards and certificates, including ISO 9001, ISO 14001, and the Responsible Care certificate for conscientious business practices within the chemical industry.
Electron Microscopy Sciences, established in 1974, is a supplier of scientific products and services, based in the United States. The company specializes in providing instruments, consumables, and chemicals for electron microscopy and histology, and they are the most comprehensive source for all fields of microscopy, histology and general laboratory research. Their network spans over 50 countries, catering to research institutions, universities, and industries worldwide. Notable achievements include strong partnerships with major manufacturers, ensuring top-notch offerings for customers.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Creative Pharmachem is a manufacturer specialized in pharmaceutical chemicals and intermediates, specifically Iodine and Bromine-based compounds, headquartered in India, and established in 1996. The company serves industries such as pharmaceuticals, biotechnology, and research laboratories. Its portfolio includes pharmaceutical intermediates, specialty chemicals, and custom synthesis solutions such as Sodium Metaperiodate, Periodic Acid at various percentages, iodic acid, sodium bromate, among others. Its products find diverse applications in these industries by supporting drug development, research, and manufacturing processes.
SR GROUP, founded in 2014 and headquartered in Delhi, India, is a supplier and distributor specializing in industrial chemicals and bio-chemical solutions. The company's product portfolio includes boronic acids, API intermediates, boronic acids with pinacol ester, melatonin powders, and various other chemicals. These products are used in various industries, including pharmaceutical manufacturing, life sciences, biotechnology, agriculture, and research institutions. The company imports its products for distribution from manufacturers in various countries, including Germany, Canada, Italy, the USA, and the United Kingdom.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Merck Millipore, founded in 1954 and headquartered in Darmstadt, Germany, is a manufacturer, distributor, and supplier of life science products and services. Their diverse range of products finds applications in research, development, and manufacturing of biotechnological and pharmaceutical drug therapies. Some of their offerings include filters for removing contaminants from liquids and gases, chromatography columns for separating and analyzing complex mixtures, reagents used in various laboratory assays, antibodies for detecting and quantifying specific molecules, and cell culture media for growing and maintaining cells in culture. Their products and services are utilized significantly in the advancement of life sciences and drug development.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Moldb, based in Hangzhou, China, is a supplier of building blocks and advanced intermediates. The company also offers a catalogue of products, including inhibitors and agonists, amino acids and peptides, catalysts and ligands, natural products, and nucleotides. The company delivers expert services and the finest products to users in the chemical and pharmaceutical R&D fields. It adheres to ISO 9001's quality management system. The companies’ analytical labs have various equipment such as GCs, HPLCs, LC-MS, TLC-MS, MS, NMR etc.
Ibuychemicals, founded in 2016 and based in Chennai, India, is a chemical distributor and an E-commerce division of the Pon Pure Chemicals Group. Its products include general, fine, lab, laundry, and food chemicals used in various applications like electronic grade cleaning, 3D printer cleaning, pyro technics, protection of metal surfaces, and as solvents in the pharmaceutical industry. The company also sells rust preventive oil, coatings, and lab glassware like beakers, bottles, and burettes. It offers free shipping for orders over 1000 Rupees, and customers can purchase 1mg to 1 ton of chemicals, which will be delivered anywhere in India.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
CHEMOS GmbH & Co. KG is a supplier of ready-to-use solutions for the lab and chemical sector. It is headquartered in Altdorf, Germany, and was established in 1974. The company supplies a range of reagents and standards for the analytical lab, as well as raw materials for the chemical and pharmaceutical sector. Some of its popular products are volumetrical reagents, standards and references, and products for research. CHEMOS also provides services such as drying, grinding and sieving, recrystallization and purification as well as contract manufacturing and contract synthesis. Its products are used in various industries, including pharmaceuticals, food, and environmental testing.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Echemi Digital Technology Co. Ltd., started in 2015 and based in Hong Kong, China, is a supplier of chemical raw materials through its B2B digital commerce platform. The company sells products such as propylene carbonate, adipic acid, and oseltamivir phosphate and serves over 100,000 buyers and over 20,000 suppliers in more than 190 countries worldwide. It also provides price and market analysis of over 500 raw materials per week in the areas of coatings, fine chemicals, and pharmaceuticals. It also covers food and nutrition and was ranked 55th in the 2022 ICIS top 100 chemical distributors.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | American Elements |
10.3%
|
2 | Parchem |
6.9%
|
3 | Ajay North America, LLC |
6.9%
|
4 | Spectrum Chemical Mfg. Corp. |
6.9%
|
5 | Aceschem Inc. |
5.2%
|
6 | Hangzhou Keying Chem Co., Ltd. |
5.2%
|
7 | Biosynth |
5.2%
|
8 | Santa Cruz Biotechnology, Inc. |
5.2%
|
9 | Kishida Chemical Co.,Ltd. |
5.2%
|
10 | FUJIFILM Wako Pure Chemical Corporation |
5.2%
|
Derivation Method
The ranking is calculated based on the click share within the periodic acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 14 | 40.0% |
United States of America | 7 | 20.0% |
Japan | 5 | 14.3% |
China | 3 | 8.6% |
Germany | 2 | 5.7% |
Canada | 1 | 2.9% |
Switzerland | 1 | 2.9% |
Spain | 1 | 2.9% |
United Kingdom | 1 | 2.9% |