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This section provides an overview for gallic acid as well as their applications and principles. Also, please take a look at the list of 13 gallic acid manufacturers and their company rankings. Here are the top-ranked gallic acid companies as of December, 2024: 1.MedChemExpress, 2.Santa Cruz Biotechnology, Inc., 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Gallic acid, an organic compound with the molecular formula C7H6O5, belongs to the class of aromatic hydroxycarboxylic acids. Known also as 3,4,5-trihydroxybenzoic acid, it is identified by the CAS registration number 149-91-7.
This compound features a molecular weight of 170.12, melts at 250°C, and forms colorless columnar crystals at room temperature. It has a density of 1.7 g/mL, an acid dissociation constant (pKa) for COOH of 4.5 and for OH of 10, and a solubility in water of 1.1 g/100mL at 20℃. Gallic acid is hygroscopic, forming a monohydrate that loses its crystalline water around 120°C.
Gallic acid is highly valued for its strong reducing power, making it a popular antioxidant in foods, cosmetics, and feed. Its alkaline solutions serve as reducing agents and photo developers. Additionally, it finds application in the production of tannins, blue ink, dyes, culture engineering reagents, plant growth regulators, and as a growth inhibitor.
Its derivatives, including propyl and isoamyl gallic acid esters, are utilized as antioxidants for fats and oils, while epigallocatechin gallate, a type of catechin, exemplifies its use in the pharmaceutical industry as astringents and for hemostatic purposes.
In water, gallic acid forms an alkaline solution with strong reducing properties, readily oxidized by air. Catalytic hydrogenation of gallic acid yields cyclohexane ring derivatives. Heating induces decarboxylation, producing pyrogallol, a valuable reagent in organic synthesis, photography, and dyeing.
Gallic acid is hygroscopic; its monohydrate is stable up to its melting point, where it decomposes into pyrogallol and carbon dioxide.
Gallic acid is available as a reagent for R&D and industrial chemical use, in quantities ranging from 10 g to 25 kg. These reagents, including the stable monohydrate, are stored at room temperature and cater to a broad range of industrial applications.
Gallic acid occurs naturally in many plants, including the Japanese knotweed and the Middle Eastern beech and oak, serving as the backbone of hydrolysable tannins. Its biosynthesis involves the cyclization of 3,5-dihydroshikimic acid, produced from 3-dehydroshikimic acid by shikimic acid dehydrogenase.
Numerous natural and synthetic ester derivatives of gallic acid are known, such as epigallocatechin gallic acid from tea. The enzyme gallic acid-1-beta-glycosyltransferase facilitates the glycosylation of gallic acid, illustrating its biochemical significance.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
United States Biological, located in Salem, Massachusetts, is a manufacturer and supplier of life science research products. Its product offerings include biochemicals, antibodies, and molecular biology kits. The company’s products are used in various fields such as genomic research, biotechnology, and pharmaceutical development. Products are available from affordable research quantities to larger bulk amounts for process development and production. Its customer base comprises pharmaceutical and biotechnology companies both in the US and overseas.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MedChemExpress |
25.3%
|
| 2 | Santa Cruz Biotechnology, Inc. |
11.4%
|
| 3 | KANTO CHEMICAL CO.,INC. |
10.1%
|
| 4 | Molekula Americas LLC |
8.9%
|
| 5 | Alfa Chemistry |
8.9%
|
| 6 | MilliporeSigma |
7.6%
|
| 7 | Alfa Aesar, Thermo Fisher Scientific. |
6.3%
|
| 8 | nacalai |
5.1%
|
| 9 | Glentham Life Sciences Limited |
3.8%
|
| 10 | Wego Chemical Group Inc |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the gallic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
6 | 54.5% |
|
Japan
|
2 | 18.2% |
|
United Kingdom
|
2 | 18.2% |
| United States | 1 | 9.1% |
