This section provides an overview for phosphorus pentachloride as well as their applications and principles. Also, please take a look at the list of 17 phosphorus pentachloride manufacturers and their company rankings. Here are the top-ranked phosphorus pentachloride companies as of November, 2024: 1.Spectrum Chemical Mfg. Corp., 2.Pharmaffiliates, 3.Pharma Chemicals Industries.
Table of Contents
Phosphorus pentachloride is an inorganic compound with the formula PCl5. It is a widely used reagent in the synthesis of various substances, similar to phosphorus trichloride and phosphoryl chloride.
It has a molar mass of 208.2 g/mol, sublimates at 160°C, has a specific gravity of 2.1, and a CAS number of 10026-13-8. In its gaseous form, phosphorus pentachloride exhibits a trigonal bipyramidal structure. Upon loss of a chloride ion, it forms a tetrahedral cation, and with an additional chloride ion, an octahedral anion.
Phosphorus pentachloride is utilized in the manufacture of pharmaceuticals, dyes, and other chlorides. Its strong reactivity makes it an effective chlorinating agent for both organic and inorganic compounds.
It is employed to produce carboxylic acid chlorides from carboxylic acids and alkyl chlorides from alcohols. While efficient, byproducts like trichloride phosphate can complicate purification, leading to the preference for alternatives like thionyl chloride in laboratory settings. Phosphorus pentachloride is also used to prepare the Vilsmeier-Haack reagent, aiding in the synthesis of aromatic ketones and aldehydes.
It can chlorinate inorganic substances, including metals, and form adducts with metal chlorides. For example, it reacts with lithium fluoride to produce lithium hexafluorophosphate, a key electrolyte in lithium-ion batteries.
A white or pale yellow crystalline solid, phosphorus pentachloride fumes in moist air due to its high hygroscopicity. It is produced from phosphorus trichloride and chlorine gas, and is extremely reactive, especially with water, producing hydrogen chloride and phosphoric acid.
Phosphorus pentachloride is acutely toxic, corrosive, and severely irritating to skin and eyes. It poses explosion risks when reacting with water. Proper protective gear, including eyewear and rubber gloves, is essential for handling. It is regulated under various safety and health legislations, emphasizing the need for careful risk assessment and handling precautions.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Hebei Guanlang Biotechnology Co., Ltd., founded in 2007 and headquartered in Shijiazhuang, Hebei, is an ISO9001, ISO14001 and ISO 45001 manufacturer of chemical raw materials and pharmaceutical intermediates. Its range of products include pharmaceutical products, food grade additives, mineral products, veterinary drug intermediates and dye intermediates among others. The company also provides various daily & industrial chemicals as well as cosmetic raw materials. The company has branches in Hubei China, Vietnam and Mexico to expand their sales network.
Parth Industries was established in 2006 and is headquartered in Gujarat, India. The company is a manufacturer, exporter, trader, and supplier of a wide range of chemicals for the pharmaceutical, food, and research industries. The company’s product categories are broken down into sulfates, agriculture chemicals, fluoride powder, and industrial chemicals. Sulfates and agriculture chemicals are applicable for poultry and cattle farms and animal feeding. Industrial chemicals such as boric acid and potassium chloride are applicable in medicine, chemicals, and food industries.
Pharma Chemicals Industries was established in 2002 and is a manufacturer and supplier of defoamer and chemical products based in Sarigam, Gujarat, India. The company manufactures various chemical products such as flocculating agent, silicone emulsion, dispersing agent, phosphorus pentachloride chemical, and silicone defoamer. The products are applied in various industries such as textiles, construction chemicals, water treatment, pup paper processing, and paints and coatings. The company is registered and verified as an Indiamart member.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Leonid Chemicals, established in 1999 and based in Bangalore, India, is a manufacturer and supplier of laboratory chemicals. The company's product range includes Leonid, Accela, Euriso Top, CIL, and TRC. These products are designed for use in academic and research institutions, analytical and research & development laboratories, and various manufacturing processes in diverse industries. It primarily serves sectors such as pharmaceuticals, specialty chemicals, and research and development centers. The company has a portfolio of high-purity chemicals and provides services such as quality assurance, chemical abbreviations, safety guidelines, and certification assistance.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Lamit Chemicals was founded in 2019 and is a manufacturer and supplier of chemical products based in Sarigam, Valsad, Gujarat, India. The company's product portofolio includes phosphate powder, zinc sulphate, ferrous sulphate, magnesium sulphate, and nitrate powder. These chemical products are used in various industries, such as mining, agriculture, and textile. The company is a certified member of Indiamart, and its products are exported to various countries such as Egypt, Equatorial Guinea, Israel, Kuwait, and Netherlands.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
RIDDHI SIDDHI INDUSTRIES was established in 2018 and is a distributor and supplier of industrial chemical products headquartered in Ankleshwar, Gujarat, India. The company trades various chemical products, including liquid acetonitrile, mono methylamine, pyridine chemical, dimethyl formamide, and meta para cresol. These products are used in various industrial segments such as textile, plastic, rubber, paint, and dye. The company was awarded the certificate of trust as a trusted seller partner of TradeIndia in 2022.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Spectrum Chemical Mfg. Corp. |
16.5%
|
2 | Pharmaffiliates |
9.7%
|
3 | Pharma Chemicals Industries |
8.7%
|
4 | Hebei Guanlang Biotechnology Co., Ltd. |
7.8%
|
5 | Alfa Aesar, Thermo Fisher Scientific. |
7.8%
|
6 | Glentham Life Sciences Limited |
6.8%
|
7 | SimSon Pharma Limited |
5.8%
|
8 | Parth Industries |
5.8%
|
9 | Jigs chemical |
5.8%
|
10 | FTF Scientific |
4.9%
|
Derivation Method
The ranking is calculated based on the click share within the phosphorus pentachloride page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 8 | 53.3% |
United States of America | 2 | 13.3% |
Japan | 2 | 13.3% |
United Kingdom | 2 | 13.3% |
China | 1 | 6.7% |