6 Lidocaine Manufacturers in 2024
This section provides an overview for lidocaine as well as their applications and principles. Also, please take a look at the list of 6 lidocaine manufacturers and their company rankings. Here are the top-ranked lidocaine companies as of November, 2024: 1.LGM Pharma, 2.Merck, 3.Uma Brothers.
Table of Contents
What Is Lidocaine?
Lidocaine is a white to slightly yellowish crystal or powder.
It is insoluble in water, but soluble in methanol and ethanol. It is also soluble in dilute hydrochloric acid. Lidocaine hydrochloride (C14H22N2O・HCl), which is made by dissolving lidocaine in a specific proportion to dilute hydrochloric acid (HCl), is commonly used as an injectable drug.
It has a pharmacological action, binding to sodium channels in the neuronal cell membrane, and inhibiting the permeation of sodium ions. This inactivates the action potential and blocks neurotransmission.
Uses of Lidocaine
Lidocaine is used medicinally for its pharmacological effects, namely for local anesthesia and suppression of arrhythmias.
Lidocaine preparations with varying concentrations from 0.5% to 2% are distributed as local anesthetics. If used in excess of the dosage, there is a risk of side effects, such as causing convulsions or affecting the myocardium.
Properties of Lidocaine
Lidocaine is easily soluble in acetic acid and diethyl ether. Because it is insoluble in water, lidocaine hydrochloride (C14H22N2O・HCl) is mixed with dilute hydrochloric acid for intravenous use. Lidocaine hydrochloride injection is an aqueous, clear, colorless liquid.
Structure of Lidocaine
Lidocaine's chemical formula is C14H22N2O and its molecular weight is 234.34. Lidocaine hydrochloride, commonly used as an injectable drug, has the chemical formula C14H22N2O-HCl and a molecular weight of 270.8.
Other Information on Lidocaine
1. Local Anesthetic Action of Lidocaine
Lidocaine is an amide local anesthetic developed by Swedish chemists Nils Löfgren and Bengt Lundqvist.
2. Comparison of Lidocaine and Tetracaine
Lidocaine is slightly inferior to tetracaine, which is considered the most potent local anesthetic, in terms of potency and duration of action. However, lidocaine has generally been used because it is less toxic than tetracaine and has sufficient medicinal properties. It is also used in combination with tetracaine as a mixture.
Xylocaine (lidocaine) solutions for local anesthesia contain epinephrine (adrenaline), which is a vasoconstrictor. This helps to prolong the anesthetic effect and also has a hemostatic effect, limiting the amount of bleeding.
3. Comparison of Lidocaine and Procaine
Compared to procaine, lidocaine is more liposoluble and protein-binding, and has a longer anesthetic action and duration. To prolong its duration of action, it is used in combination with adrenaline. However, there are some sites where adrenaline cannot be used in combination, such as fingertips, because it can cause irreversible necrosis.
4. Pharmacological Effects of Lidocaine
Lidocaine binds to sodium channels and blocks neurotransmission by inhibiting the permeation of sodium ions, so it inactivates the action potential. Sodium channels, a type of ion channel, are also involved in cardiac rhythm and can therefore be used to treat arrhythmias.
Specifically, 0.5%, 1%, and 2% Lidocaine preparations are commercially available as local anesthetics. It can be used for surface anesthesia, transfer anesthesia, infiltration anesthesia, spinal anesthesia, and epidural anesthesia.
As an antiarrhythmic agent, lidocaine falls into group Ib of the Bourne-Williams classification. This group, with the exception of aprindine, is indicated only for ventricular arrhythmias. In addition, lidocaine is available over the counter as a topical and nasal solution for antipruritic use.
List of 6 Lidocaine Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- India
- Japan
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LGM Pharma
Lidocaine
Manufacturer Overview
LGM Pharma, established in 2005 and headquartered in Florida, USA, is a manufacturer of API sourcing and drug product lifecycle solutions. The company specializes in complex drug development projects such as 505(b)(2) submissions and offers contract development and manufacturing services in the pharmaceutical industry. Its active pharmaceutical ingredients are used for injectable formulations, transdermal patches, and sublingual drug deliveries. It also covers formulation development, stability studies, and commercial production for injectables, transdermals, and inhalation therapies. With cGMP systems aligned with ICH Q7 standards, the company serves the biotech, specialty pharma, and generics sectors.
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KANTO CHEMICAL CO.,INC.
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Merck
Lidocaine
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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Uma Brothers
Lidocaine
Company Overview
Uma Brothers was established in 1978 in Mumbai, Maharashtra, and is a manufacturer and supplier of pharmaceutical chemicals and intermediates for confectionary, brewery and distillery, and ayurvedic industries. Its product catalog includes Vardenafil HCL trihydrate, Sodium starch glycolate, and Sevelamer carbonate. The company supplies the chemicals to Oman, Vietnam, Canada, and many more countries around the world. Apart from being a member of Pharmexcil Council, the company is Indian F.D.A. certified.
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Lidocaine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | LGM Pharma |
45.0%
|
| 2 | Merck |
16.3%
|
| 3 | Uma Brothers |
11.6%
|
| 4 | Atom pharma |
9.6%
|
| 5 | NIiksan Pharmaceutical |
8.8%
|
| 6 | KANTO CHEMICAL CO.,INC. |
8.8%
|
Derivation Method
The ranking is calculated based on the click share within the lidocaine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Uma Brothers: 8
Newly Established Company
- NIiksan Pharmaceutical: 2013 (11 years ago)
- Uma Brothers: 1978 (46 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
Company with a History
- LGM Pharma: 1924 (100 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Uma Brothers: 1978 (46 years ago)
Lidocaine Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Lidocaine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
3 | 60.0% |
United States of America
|
1 | 20.0% |
Japan
|
1 | 20.0% |
