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This section provides an overview for morpholine as well as their applications and principles. Also, please take a look at the list of 13 morpholine manufacturers and their company rankings. Here are the top-ranked morpholine companies as of December, 2024: 1.Merck, 2.ChemCeed LLC, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Figure 1. Basic Information on Morpholine
Morpholine, an organic compound with the molecular formula C4H9NO, also known as tetrahydro-2H-1,4-oxazine, is a colorless liquid at room temperature. As a skin irritant and flammable substance, it requires careful handling due to potential adverse effects on the kidneys and liver from long-term exposure.
It is classified as a hazardous and flammable substance under various laws, requiring caution in its handling.
Primarily, morpholine serves as a vulcanization accelerator in synthetic rubber manufacturing. Due to carcinogenic nitrosamines produced during vulcanization, regulations have tightened, prompting the development of safer accelerators. Additionally, morpholine forms the backbone of various pharmaceuticals, including analgesics, sedatives, and local anesthetics.
With a melting point of -5°C and a boiling point of 129°C, morpholine exhibits hygroscopic properties and has a distinctive amine odor. Its flash point is 38°C. Soluble in water, its basic nitrogen atom contributes to the formation of morpholinium ions in solution, with a pKa of 8.33.
Morpholine features both amine and ether functional groups, resembling cyclohexane with two opposing carbon atoms replaced by an oxygen and a nitrogen atom. This heterocyclic amine has a molecular weight of 87.12 and a density of 1.007 g/cm3.
Figure 2. Synthesis of Morpholine
Morpholine is industrially synthesized through the dehydration of diethanolamine (DEA) using sulfuric acid. DEA is a compound combining features of diols and secondary amines.
Figure 3. Reactions of Morpholine
Morpholine's conjugate acid, morpholinium, forms through the reaction with hydrochloric acid, producing morpholine hydrochloride, a colorless liquid with a weak ammonia-like odor. Named by Ludwig Knorr, morpholine was once mistakenly associated with morphine. Its ether oxygen lowers the nitrogen atom's electron density, reducing its nucleophilicity and basicity compared to similar secondary amines.
In organic synthesis, morpholine is instrumental in producing the antibiotic linezolid, the anticancer drug gefitinib, and the analgesic dextromoramide. It also facilitates enamine production, serving as a versatile synthetic intermediate and solvent in various industrial applications.
*Including some distributors, etc.
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ChemCeed, founded in 2009 and headquartered in Chippewa Falls, Wisconsin, is a worldwide chemical supplier that is ISO 9001 certified. It provides chemicals like base oils, corrosion inhibitors, and specialty esters used in several industries, including construction, paper manufacturing, and water treatment. It also provides a broad selection of support services, including labeling, repackaging, and logistical support. The company stocks its products in several locations around the United States, including Chicago (IL), Philadelphia (PA, and Piscataway (NJ). In 2016, it received WBE certification and was NACD verified in 2023.
Knowde is an online marketplace connecting buyers and sellers of chemicals, ingredients, and materials. Founded in 2017 and based in Austin, Texas. The company makes buying and selling in the chemical industry easier by giving users an easy-to-use platform. Knowde offers a wide range of products, from specialty chemicals and raw materials to finished products and formulations, all available for purchase with a few clicks. With its robust search capabilities, powerful analytics, and personalized customer service.
UL LLC was established in 1894 and is located in Northbrook, Illinois, US, as a supplier of safety certifications. It provides certification, inspections, auditing, testing, and performance validation to meet safety concerns. The products are used in plastics and elastomers suppliers to manufacture sustainable and safe products. Also, the products are essential in adhesives & sealants, metalworking, household and industrial cleaners. The company's services include digital marketing for suppliers, regulatory compliance, and improved search functionality to enhance competitiveness.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Rock Chemie Industrial Group, established in 1989 and based in Tehran, Iran, is a manufacturer of raw materials. The company manufactures various chemicals in different industries, such as water, petrochemicals, cosmetics, mining and oil & gas. The company also produces petroleum and agricultural additives and pesticides. The company adheres to various standards while manufacturing raw materials, such as ISO10004, ISO10002, ISO45001, ISO14001, and ISO9001. The company is recognized as the national model exported four times.
Elite Chemicals, established in 1975 and based in Bhavnagar, Gujarat is a manufacturer of drugs and pharmaceutical inorganic chemicals. The company produces acetone, adipic acid, buthyl glycol, sodium gluconate, titanium dioxide, barium chloride and boric acid. The chemicals are largely used in artificial leather and polyurethane, textile, metallurgy, construction, galvanizing and paint sectors. The wide range of chemicals is used by clients like LG, Shell, BASF, Inovyn, Dow, and Thwater. The strong sales team and supplier chain have made the business evolve.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
CATO Research Chemicals Inc. is headquartered in Guangzhou City, Guangdong Province, in China. The company performs research and development and production of more than 32000 standard products and 48000 analytical reference material products for manufacturing, agriculture, pharmaceutical, and chemical markets. The company distributes a range of chemicals from raw materials to intermediates to analytical testing and customized synthetic compounds. The categories of chemicals that the company sells include plant growth regulators, polychlorinated biphenyls, volatile organic compounds, ketones, and fatty alcohols.
Ataman Kimya A. S (Ataman Chemicals LLC), founded in 1940 and based in Istanbul, Turkey, is a supplier of pharmaceuticals and chemical raw materials. Ataman Kimya A. S serves industries including agriculture, cosmetics, food additive, petroleum, among others with products such as disinfectants, cosmetics, metal and mining chemicals, textile and leather chemicals, paints, as well as industrial and pharmaceutical chemicals. The company holds the sales and marketing rights of Nordic Chemical Laboratories and is known for the enviromental care it provides.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | ChemCeed LLC |
15.8%
|
| 2 | Merck |
15.8%
|
| 3 | KANTO CHEMICAL CO.,INC. |
10.5%
|
| 4 | Rock Chemie industrial group |
8.8%
|
| 5 | Knowde |
8.8%
|
| 6 | Junsei Chemical Co.,Ltd. |
7.9%
|
| 7 | Elite Chemicals |
6.1%
|
| 8 | nacalai |
6.1%
|
| 9 | PROSPECTOR |
5.3%
|
| 10 | Wego Chemical Group Inc |
5.3%
|
Derivation Method
The ranking is calculated based on the click share within the morpholine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 36.4% |
|
Japan
|
3 | 27.3% |
|
Turkey
|
2 | 18.2% |
|
Switzerland
|
1 | 9.1% |
| Iran | 1 | 9.1% |
