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This section provides an overview for maleimide as well as their applications and principles. Also, please take a look at the list of 33 maleimide manufacturers and their company rankings. Here are the top-ranked maleimide companies as of December, 2024: 1.Omega Pistons Limited, 2.Oakwood Products, Inc, 3.Glentham Life Sciences Limited.
Table of Contents
Maleimide is an organic compound derived from maleic acid, featuring two carbonyl groups, and is represented by the chemical formula C4H3NO2.
It is a white, powdery solid at room temperature and pressure, soluble in water, ethanol, and other organic solvents. Maleimide is synthesized by reacting maleic anhydride with zinc chloride and heating. Various maleimide derivatives, such as N-phenylmaleimide, are used as resins and cross-linking agents.
Some maleimide derivatives, including N-phenylmaleimide, are classified as poisonous and toxic.
Maleimide is utilized in biological research for protein and peptide modification. It reacts with cysteine residues, which contain thiol groups, to form covalent bonds. This reactivity is also employed in cross-linking agents for polymers and gels.
Maleimide derivatives are widely used for various applications.
Typical derivatives include:
Maleimide is a colorless crystalline solid that is heat-sensitive and decomposes upon heating. It is virtually insoluble in water but soluble in polar solvents like alcohol and acetone. Maleimide also exhibits absorption bands in the ultraviolet and visible light spectrum.
It is highly reactive with compounds containing thiol groups, forming covalent bonds through Michael addition and thiol-ene reactions.
Due to these properties, maleimide finds applications in various fields, including biological research and synthetic organic chemistry.
Maleimide, an organic compound, has the molecular formula C4H2NO2.
Its imide ring is planar and resonance-stabilized, allowing electron distribution throughout the ring due to resonance effects. This resonance stabilization makes maleimide highly chemically reactive.
A carbon-carbon double bond within the maleimide molecule plays a crucial role in certain chemical reactions, such as the Diels-Alder reaction.
Maleimide can be synthesized using different methods, with two common methods detailed below:
Synthetic Method Using Maleic Anhydride and Urea
This method involves mixing maleic anhydride and urea in a 1:1 molar ratio and heating. It is widely used in industry due to its simplicity and use of inexpensive materials.
Synthetic Method Using Maleic Anhydride and Ammonia
Here, maleic anhydride is mixed and heated with ammonia. While this method yields a high product yield, handling ammonia is challenging, and costs are higher than the urea method. Therefore, the method using maleic anhydride and urea is often preferred on an industrial scale.
*Including some distributors, etc.
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Oakwood Chemical is based in Estill, South Carolina. The company is a producer of a wide range of organics with particular emphasis on fluorine and sulfur compounds. The company also offers custom synthesis services and bulk quantities upon request. The company has independent operations and operations in collaboration with the University of South Carolina. The company’s suppliers include ChemCollect, Chess, KISHIDA CHEMICAL Co., Ltd., and Tetramer. The company’s featured products include boronic acids and esters, peptide coupling, fluorinated amines, and reagents for synthesis.
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
BroadPharm, founded in San Diego, CA, in 2009 is a manufacturer of PEG Linkers, Click Chemistry reagents and Bio-labeling reagents such as Dye Labeling and Biotin Labeling. The company's product portfolio includes Lipids In Drug Delivery, Fluorescent Dye, Biotinylation Reagents, Dye Antibody Labeling Kit and Biotin Antibody Labeling Kit. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare.
Ambeed, established in 2015 and headquartered in Arlington Heights, Illinois, is a manufacturer and supplier of catalog products, including inhibitors, natural products, nucleotides, building blocks, and amino acids. The company mainly specializes in organoboron, metal catalysts, heterocyclic building blocks, and materials science-related products. Its catalog has more than 100,000 in-stock products, increasing monthly. As of 2019, the company’s R&D center had developed five product lines with over 600,000 products. The company provides pre-sale and after-sale services and works with distributors from several countries, including India, Pakistan, Egypt, Poland, and Brazil.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Southside Equipment, Inc., based in Louisville, KY, USA, is a manufacturer and distributor of multi-line power equipment. The company also offers pressure cleaning machines, wastewater recovery and recycling machines, high-grade power generators, and chemical cleaning supplies. The company’s pressure cleaning equipment lines include Hydro Tek, Pressure Pro, BE Pressure Supply, Delco/Simpson, and Epps. It makes chemicals for vehicle washing, degreasing, concrete removal, and residential and commercial structure cleaning. The company has equipment from Steel Eagle, Sirocco, and Hydro Tek for waste water treatment.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Thermo Fisher Scientific Inc., founded in 1956 and headquartered in Waltham, Massachusetts, is a manufacturer and supplier of life science solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services. Through its brand names, including Invitrogen, Fisher Scientific, Patheon, Applied Biosystems, and Gibco, among others, the company provides a wide range of products, which include chromatography systems, thermal cyclers, automated cell counters, fermenters, and DNA polymerases. The company’s annual revenue is over 40 billion USD, and it serves several fields, including customers working in clinical diagnostic labs, research institutions, hospitals, government agencies, and pharmaceutical/biotech companies.
BenchChem, an American company located in Pasadena, California, is a supplier specializing in chemicals and biochemicals for laboratory and research and development use. The company’s product portfolio includes inhibitors, chemical reagents, bioactive chemicals, lead compounds, and catalysts. These products cater to various industries, including pharmaceutical companies, biotechnology firms, academic and research institutions, chemical and materials science researchers, as well as environmental and analytical laboratories. The company provides customer services, including contract manufacturing and analytical services.
AA BLOCKS, INC., headquartered in San Diego, California, is a research chemical supplier specializing in providing building blocks and intermediates. Its product range encompasses diverse building blocks essential for drug development and medical and biochemical research. These include compounds like 2,2-bis(hydroxymethyl)butanoic acid and 5-(Chloromethyl)-3-phenylisoxazole, catering industries such as pharmaceutical, biotechnology, and agrochemical industries. The company's products are used by scientists and researchers to develop new drugs, therapies, and other products. Its products are also used to study the biological effects of different compounds, offering efficient and cost-effective solutions to scientists.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
ARRK Engineering GmbH, established in 1967 and headquartered in Munich, Germany, operates as a motor vehicle manufacturer serving the automotive and mobility industries. The company's product offerings include digitalization & software, car bodies & high-voltage batteries, powertrains, chassis, and interior & exterior solutions. These products cater to a diverse range of sectors, including optical systems, electronics & software, acoustics, thermal management, and the automotive industry. The company collaborates with partners including IPETRONIK, FutureCamp, and Synera.
Manchester Organics Ltd., established in 1996 and headquartered in Cheshire, England, is a manufacturer of organic building blocks, intermediates & research chemicals. The company offers over 50,000 building blocks and fine organic chemicals. It specializes in fluorination technology and general organic synthesis at all scales and provides a chemically diverse range of custom synthesis services, development and scale-up projects. The company has multiple milligram to multi-kilo production facilities with high pressure capability and cGMP specialist fluorination facility.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Nippon Shokubai Co. LTD., established in 1941 and headquartered in Osaka, Japan, is a chemical manufacturer providing diverse chemical materials. Some of its products include detergents, curing agents, heat-resistant resins, adhesives, and coatings for metal, and the products are used in various industries, including life science, ICT, consumer products, environment remediation, and energy. In 1941, the company started the first commercial production of Phthalic Anhydride, which led to the development of the vinyl chloride industry. It commercialized Ethylene Oxide in 1959 using domestic technologies and began mass-producing superabsorbent polymers in 1985.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Hunan Huateng Pharmaceutical Co. Ltd., established in 2013 and based in Changsha, China, is a supplier of PEG derivatives and a contract manufacturer of APIs and intermediates. It stocks chemical reagents, vaccine excipients, APIs, and pharmaceutical intermediates, among other chemicals. In 2016, the company launched the first R&D center in Changsha, and in 2020, it completed the construction of its company, which started operations. It is ISO 9001 certified and has a range of facilities to manufacture and store chemical products up to 10 Metric Tons.
Lab Pro Inc. (LP) is an American manufacturer and distributor of laboratory equipment and supplies that was established in Sunnyvale, California in 1979. The company produces various chemical products including reagents, oxidizers, and acids, as well as personal protective equipment (PPE), microscopes, and laboratory hand tools. It also offers laboratory instrumentation and utensils such as refractometers, forceps, and pH meters. Aside from its products, LP also provides vendor-managed inventory and lab chiller leasing services for its clients in industrial research facilities, academic institutions, and R&D testing laboratories.
ALADDIN is a manufacturer and supplier of research and development reagents that was established in Shanghai, China, in 2009. Its biochemical reagents are used in the life sciences, materials science, and chemistry fields. The company manufactures drug target ligands, antibodies, and proteins as well. It also supplies testing services and laboratory equipment for high-end users. It works in technological, biological, and scientific, research too. Its inventory is used in the biological science and analytical chemistry industries.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Yuanfar International Trade Company, established in 2001 and headquartered in Xi'an, Shaanxi, China, is a distributor of nonferrous metals, chemicals, and solar-photovoltaic products while providing professional foreign trade supply chain services. Its product range includes chemicals like Hydrazine hydrate, Mono-methyl hydrazine, DMF, Acetonitrile, and Fluorine products, serving diverse industries and exporting to countries such as Europe, the USA, India, and Japan. With two decades of experience, the company has cultivated strong partnerships with chemical companies in China, contributing to global trade.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Echemi Digital Technology Co. Ltd., started in 2015 and based in Hong Kong, China, is a supplier of chemical raw materials through its B2B digital commerce platform. The company sells products such as propylene carbonate, adipic acid, and oseltamivir phosphate and serves over 100,000 buyers and over 20,000 suppliers in more than 190 countries worldwide. It also provides price and market analysis of over 500 raw materials per week in the areas of coatings, fine chemicals, and pharmaceuticals. It also covers food and nutrition and was ranked 55th in the 2022 ICIS top 100 chemical distributors.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Omega Pistons Limited |
7.7%
|
| 2 | Oakwood Products, Inc |
7.7%
|
| 3 | Glentham Life Sciences Limited |
7.7%
|
| 4 | BE ATEX |
3.8%
|
| 5 | ARRK Engineering GmbH |
3.8%
|
| 6 | Southside Equipment, Inc. |
3.8%
|
| 7 | AA BLOCKS, INC. |
3.8%
|
| 8 | Manchester Organics Ltd. |
3.8%
|
| 9 | Lumiprobe GmbH |
3.8%
|
| 10 | Click Chemistry Tools |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the maleimide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
13 | 54.2% |
|
United Kingdom
|
3 | 12.5% |
|
Germany
|
2 | 8.3% |
|
China
|
2 | 8.3% |
France
|
2 | 8.3% |
|
Canada
|
1 | 4.2% |
|
Japan
|
1 | 4.2% |
