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This section provides an overview for benzonitrile as well as their applications and principles. Also, please take a look at the list of 13 benzonitrile manufacturers and their company rankings. Here are the top-ranked benzonitrile companies as of December, 2024: 1.Pharmaffiliates, 2.Kerafast, 3.Gansu Puluowangda International Trade Co. , Ltd.
Table of Contents
Benzonitrile, an aromatic cyanide with the formula C6H5CN, was identified by Hermann von Fehling in 1844 during the decomposition of ammonium benzoate. This discovery led to the term "nitrile" for similar compounds. Classified under various regulations as a hazardous substance, a flammable liquid, and a deleterious substance, it requires careful handling.
As a versatile chemical, benzonitrile serves as a precursor to benzoic acid, benzylamine, and triazine rings through various reactions. Its applications span from plastics manufacturing to pharmaceutical and agricultural intermediates, solvents for antioxidants, plating solutions, dye construction, and epoxy resin curing agents.
This colorless liquid features an almond-like scent, a melting point of -13°C, and boils between 188-191°C. It's flammable, with a flash point of 75°C and an ignition point of 550°C, soluble in alcohols and ethers, yet only 1% soluble in water at 100°C.
Known as phenyl cyanide, its structure includes a benzene ring with a cyano group substituting one hydrogen atom, abbreviated as PhCN. It has a molar mass of 103.04 g/mol and a density of 1.0 g/ml.
Benzonitrile is produced industrially by the ammoxidation of toluene and can be synthesized in the lab through dehydration of benzamide or benzaldehyde oxime. It's also obtained via Rosenmund-von Braun synthesis or by diazotizing aniline in the Sandmeyer reaction.
Hydrolysis converts benzonitrile to benzoic acid, while reactions with amines yield N-substituted benzamides. It forms complexes with late transition metals, such as bis(benzonitrile)palladium dichloride, a yellowish-brown solid used in organic synthesis, showcasing its role as a convenient synthetic intermediate.
*Including some distributors, etc.
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Kerafast is a manufacturer and supplier of reagent that is based in Boston, Massachusetts and was founded in 2011. The company makes and supplies laboratory-made research tools, including cell lines, antibodies, small molecules, and dyes. Kerafast wants to make unique laboratory-made research tools easily accessible to the global scientific community. Its products are available through its online platform, where researchers can find and purchase. Kerafast also offers a number of services to help researchers, such as technical support, custom synthesis, and sample storage. The company's products are used in many research areas, including cancer research, drug discovery, and cell biology.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
CATO Research Chemicals Inc. is headquartered in Guangzhou City, Guangdong Province, in China. The company performs research and development and production of more than 32000 standard products and 48000 analytical reference material products for manufacturing, agriculture, pharmaceutical, and chemical markets. The company distributes a range of chemicals from raw materials to intermediates to analytical testing and customized synthetic compounds. The categories of chemicals that the company sells include plant growth regulators, polychlorinated biphenyls, volatile organic compounds, ketones, and fatty alcohols.
CDN Isotopes Inc. has been a provider of deuterium-labelled compounds since its establishment in 1993. Located in Quebec, Canada, they supply researchers in the fields of medicine and science. They have over 3000 products and 98%of their orders are filled from stock. CDN isotopes have international distributors in over 40 countries and have continued to add new products to the market. They aim to provide customers with products at affordable prices while maintaining a large inventory of products.
Gansu Puluowangda International Trade Co., Ltd. is a chemical supplier based in Yumen City, Gansu, China that was established in 2013. The company specializes on importing and exporting casein products, Chinese wolfberry, sunflower seeds, pesticide intermediates, pharmaceutical intermediates, dye intermediates and other wide range of chemicals for industrial and research applications. Its main products include organic chemicals, inorganic chemicals, and polymers. Some of its popular products are ethylene glycol, glycerin, and sodium hydroxide. Gansu Puluowangda also offers services such as technical support, custom synthesis, and packaging. Its products are used in many industries, including plastics, textiles, and pharmaceuticals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Pharmaffiliates |
41.7%
|
| 2 | Kerafast |
16.7%
|
| 3 | Gansu Puluowangda International Trade Co. , Ltd |
16.7%
|
| 4 | CATO |
8.3%
|
| 5 | KANTO CHEMICAL CO.,INC. |
8.3%
|
| 6 | Merck |
8.3%
|
Derivation Method
The ranking is calculated based on the click share within the benzonitrile page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 45.5% |
|
Canada
|
2 | 18.2% |
|
United States of America
|
1 | 9.1% |
|
India
|
1 | 9.1% |
|
United Kingdom
|
1 | 9.1% |
|
China
|
1 | 9.1% |
