11 Fumaric Acid Manufacturers in 2024
This section provides an overview for fumaric acid as well as their applications and principles. Also, please take a look at the list of 11 fumaric acid manufacturers and their company rankings. Here are the top-ranked fumaric acid companies as of November, 2024: 1.Wuhan Demeikai Biotechnology Co. Ltd., 2.ZIBO ANQUAN CHEMICAL CO., LTD., 3.Shaanxi Worthful Herb Biotech Co., Ltd..
Table of Contents
Okayama University Graduate School, Ph.D. (Agriculture). After working as a specially appointed Assistant Professor at Tokyo Medical and Dental University, a fluid researcher at the Okayama Prefectural Institute of Biological Sciences, and a special researcher (JSPS PD) at the Japan Society for the Promotion of Japan Science, he became independent as a freelancer.
Specializes in natural product chemistry, protein engineering, fermentation engineering, and instrumental analysis of chemicals (especially mass spectrometry chemistry).
Thesis: https://pubmed.ncbi.nlm.nih.gov/?term=HIROKAZU+USUKI
linkedin: https://www.linkedin.com/in/%E5%8D%9A%E4%B8%80-%E8%87%BC%E6%9C%A8-b83827228/
What Is Fumaric Acid?
Fumaric acid is the simplest unsaturated dicarboxylic acid and is widely found in nature. It is a colorless crystalline powder with no odor but a strong sour taste. Industrially, fumaric acid is mainly produced by isomerizing maleic acid, a geometric isomer of fumaric acid.
Physicochemical Properties of Fumaric Acid
1. Name
English name: fumaric acid
IUPAC name: (2E)-but-2-enedioic acid
2. Molecular Formula
C4H4O4
3. Molecular Weight
116.07 4. melting point
4. Melting Point
300-302℃ (in sealed tube)
5. Solvent Solubility
Soluble in ethanol, insoluble in water, insoluble in benzene
Characteristics and Uses of Fumaric Acid
1. Use as a Fungicide
This compound is used as a disinfectant for fresh food due to its bactericidal properties. Its mechanism of action is as follows.
Fumaric acid's mechanism of action as a fungicide:
- The carboxyl group is taken into the bacteria in a non-resolved state.
- The dissociation of the carboxyl group in the cytoplasm lowers the pH of the cytoplasm.
- As a result of (2) above, enzyme activity in the cytoplasm decreases, inducing metabolic abnormalities and killing the bacteria.
2. Examples of Use in the Food Industry, Livestock Industry, and Medical Field
Fumaric acid is recognized as safe as a food additive, and is used as an acidulant, expander, pH adjuster, and seasoning. In the livestock and agricultural fields, fumaric acid is used as an additive in feed and as a fungicide and algaecide for plants. In the industrial field, it is used as a raw material for synthetic resins and dyes. In the medical field, fumaric acid esters made from fumaric acid are being studied for their effectiveness in treating psoriasis.
3. Role in the body
Fumaric acid plays an important role in the energy production process of organisms that breathe oxygen. Specifically, it exists as an intermediate in the citric acid circuit, where it is produced from succinic acid and converted to malic acid.
Differences in Chemical Properties Between Fumaric Acid and Maleic Acid
Fumaric acid has geometric isomers. The trans form is fumaric acid and the cis form is maleic acid.
Interestingly, the chemical properties of these compounds are very different. Specifically, fumaric acid, the trans form, is less prone to intramolecular dehydrocondensation than maleic acid, and its solubility in water is much lower than that of maleic acid. These differences in properties can be explained by the steric positioning of the two carboxyl groups in these isomers. Please refer to the following article for a detailed explanation of this principle.
List of 11 Fumaric Acid Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- China
- Japan
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Actylis
Fumaric Acid
Company Overview
Actylis is based in Port Washington, New York, USA, and is an ISO 13485-certified custom manufacturer of chemical compounds that was established in 1978 as a subsidiary of Aceto. The company mainly produces specialty chemical products for the pharmaceutical, biopharm, and agriscience sectors. These chemical products include cell culture ingredients, active pharmaceutical ingredients (APIs), and buffering salts. It also offers excipients, adenosine for cosmetic ingredients, and vitamins for nutritional supplements. The company operates internationally, with manufacturing facilities in Germany, the United Kingdom, and India. Some of its notable clients include Novartis, Nestlé, and Estée Lauder.
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Parchem
Fumaric Acid
Distributor Overview
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
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KANTO CHEMICAL CO.,INC.
Fumaric acid
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Junsei Chemical Co.,Ltd.
Fumaric Acid
Manufacturer Overview
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
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Awell Ingredients Co.,Ltd.
Fumaric Acid
Manufacturer Overview
Awell Ingredients Co.,Ltd., established in 2009, based in Hefei, China, is a manufacturer of functional ingredients. The company’s product portfolio includes amino acids, vitamins, food ingredients, nutritional supplements, plant extracts, and feed additives. The products’ ingredients comply with FCC, USP, BP, EP, AJI and JP standards. It also exports agents of various Chinese factories, to provide worldwide customers with competitive prices and good payment terms.The company provides products and services with endless opportunities and more economical solutions for customer products. Its main objective is to provide organic and green ingredients.
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ZIBO ANQUAN CHEMICAL CO., LTD.
Fumaric Acid
Manufacturer Overview
ZIBO ANQUAN CHEMICAL CO., LTD was founded in 1999, and its headquarters is in Zone Zibo, Shandong, China, as a pyromellitic dianhydride and pyromellitic acid manufacturer. The primary products of ZIBO ANQUAN CHEMICAL CO., LTD are primarily utilized as the primary material for polyimide production. The crude forms of PMDA and PMA are predominantly employed in manufacturing curing matting agents for epoxy resins. The primary application of iron-free aluminium sulfate is in water treatment.
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Xingtai Xingjiu New Material Technology Co., Ltd.
Fumaric Acid
Manufacturer Overview
Xingtai Xingjiu New Material Technology Co Ltd., founded in 2018 and located in Guangzong Economic Zone Xingtai City, Hebei Province, China, is a manufacturer of industrial intermediates, cosmetic raw materials, and plant extracts. The company produces additives, disinfectants, antiseptics, veterinary raw materials, and chemical intermediates. The company maintains an ISO 9001 quality management system, along with ISO 9000 and GMP certifications. It collaborates with quality inspection departments, customer service offices, and agents in South America, Asia, Europe, Australia, and Central America.
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Shaanxi Worthful Herb Biotech Co., Ltd.
Fumaric Acid
Manufacturer Overview
Shaanxi Worthful Herb Biotech Co., Ltd., founded in 2017 in Gaoxin, Xi’an, Shaanxi, China, is a manufacturer of active constituents from natural herbs. The company produces vegetable powders, cosmetic raw materials, plant extracts, pharmaceutical intermediates, and healthcare products used for hair growth and prevention of hair loss. The firm has a GMP standard production line, a research and development work team, and a management system with certifications such as ISO 9001, HACCP, and ISO 14001.
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nacalai
Fumaric Acid
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Thirumalai Chemicals Ltd.
Fumaric Acid
Company Overview
Thirumalai Chemicals Ltd was founded in 1672, and its headquarters is in Sion East, Mumbai, India, as a producer of Phthalic Anhydride, Malic Acid, Maleic Anhydride and Fumaric Acid. TCL takes superiority in manufacturing items utilized in individuals' daily lives. The company produces and promotes various goods catering to the needs of the plastics, paints, food, cosmetics, and pharmaceutical sectors. It has also established a commendable name for its excellence and reliability, attributed to its utilization of cutting-edge production facilities that guarantee punctual delivery and efficient logistics.
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Fumaric Acid Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Wuhan Demeikai Biotechnology Co. Ltd. |
24.0%
|
| 2 | ZIBO ANQUAN CHEMICAL CO., LTD. |
14.0%
|
| 3 | Shaanxi Worthful Herb Biotech Co., Ltd. |
12.0%
|
| 4 | Awell Ingredients Co.,Ltd. |
12.0%
|
| 5 | Actylis |
10.0%
|
| 6 | Xingtai Xingjiu New Material Technology Co., Ltd. |
8.0%
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| 7 | Thirumalai Chemicals Ltd. |
6.0%
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| 8 | Parchem |
6.0%
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| 9 | Junsei Chemical Co.,Ltd. |
4.0%
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| 10 | nacalai |
4.0%
|
Derivation Method
The ranking is calculated based on the click share within the fumaric acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Junsei Chemical Co.,Ltd.: 171
Newly Established Company
- Xingtai Xingjiu New Material Technology Co., Ltd.: 2018 (6 years ago)
- Parchem: 1999 (25 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
Fumaric Acid Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Fumaric Acid Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
Japan
|
3 | 37.5% |
China
|
3 | 37.5% |
United States of America
|
2 | 25.0% |
