All Categories
History
This section provides an overview for phenolphthalein as well as their applications and principles. Also, please take a look at the list of 16 phenolphthalein manufacturers and their company rankings. Here are the top-ranked phenolphthalein companies as of December, 2024: 1.Jigs chemical, 2.Amerigo Scientific., 3.Oxford Lab Fine Chem LLP.
Table of Contents
Phenolphthalein is an organic compound with the chemical formula C20H14O4.
It is used as an acid-base indicator in analytical chemistry because its solution color changes depending on pH.
The CAS number is 77-09-8. It has a molecular weight of 318.32, a melting point of 258-263°C, and is a white or pale yellow solid at room temperature. It is insoluble in water.
In other solvents, it is slightly soluble in ethanol, insoluble in diethyl ether, insoluble in benzene, and slightly soluble in DMSO. Its density is 1.277 g cm-3.
A typical use for phenolphthalein is as an acid-base indicator in analytical chemistry. Phenolphthalein is dissolved in ethanol or a mixture of ethanol and water to form a solution of Phenolphthalein, which turns reddish purple when basicity is detected.
One example of application of its properties as an acid-base indicator is in concrete inspection. As concrete deteriorates, carbonate is formed and the pH decreases. Therefore, Phenolphthalein can be used to check the deterioration of concrete based on the principle that only new concrete will color and old concrete will not.
Other applications include blood detection (Casull-Meyer test), cadmium and gold detection, matting ink, and hair dye for toy dolls. It was once used as a laxative, but is no longer used clinically due to its suspected carcinogenicity in rodent experiments.
Phenolphthalein is synthesized by heating and mixing phthalic anhydride and phenol under acidic conditions, resulting in the condensation of two molecules of phenol for one molecule of phthalic anhydride. It is characterized by the possibility of alteration by light.
Therefore, it must be stored away from high temperatures and direct sunlight. In addition, mixing with strong oxidizers is hazardous, and decomposition products include carbon monoxide (CO) and carbon dioxide (CO2).
Phenolphthalein is sold by reagent manufacturers primarily as a reagent and indicator for testing and research. In addition to the pure product, there is a 1.0w/v% ethanol solution product that can be used as-is as an indicator for neutralization titration.
The purity products are available in 25g, 100g, 500g, etc. The 1.0 w/v% ethanol solution products are available in volumes of 100mL, 500mL, etc. They are treated as reagent products that can be stored at room temperature. These are reagents that can be stored at room temperature.
To prevent alteration by light, brown glass bottles may be used for packaging.
Phenolphthalein solution is characterized by a color change with pH. It is widely used as an acid-base indicator because the color change is clear and is not easily affected by coexisting substances.
It is colorless in acidic conditions below pH 8.3, pink to reddish purple in basic conditions between pH 8.3 and 13.4, and colorless again in more basic conditions than pH 13.4. This is due to the fact that, under basic conditions, the phenol moiety undergoes deprotonation, resulting in a change in molecular structure.
Phenolphthalein is known to be harmful to the human body, including the risk of carcinogenesis and hereditary diseases. For this reason, it has been designated as a "hazardous and toxic substance."
*Including some distributors, etc.
Sort by Features
Sort by Area
Amerigo Scientific., founded in New York, US, is a distributor of Automated Nucleic Acid Extraction Systems, biomedical and chemical products. The company's product portfolio includes 3D Bioprinters, Biomaterials & Bioinks, Cells, Cell Media & reagents, Lab Equipment and Electrophoresis Systems. Their products are used in industries such as Food and Beverage , Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company also provides services including national distribution, product selection, customized services, technical support and customer service.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Suvidhinath Laboratories was founded in 1985 and is headquartered in Gujarat, India. The company is an ISO 9001-2008 certified exporter, manufacturer, trader, and supplier of laboratory chemicals and reagents to global customers, especially across South East Asia and the Gulf countries. The company’s client list includes Cadila Pharmaceuticals Limited, Gujarat State Fertilizers & Chemicals LTD, Deepak Nitrite Limited, and Indian OIl. The company’s product categories include food-grade chemicals, pharmaceutical chemicals, laboratory chemicals, and industrial chemicals.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Longchang chemical Co., Ltd., is a chemical manufacturer company and was established in 1996, located in Changyi City, China. The company with a close cooperation with the School of Chemistry and Molecular Engineering of Peking University and Qilu University of Technology, is constantly developing new products, from the initial sodium silicate to the subsequent main products and by-products of petroleum resin series. In 2015, they opened a new laboratory, making a major breakthrough in flame retardant and plasticizer and light curing products. They have passed the ISO-9001 quality system certification in 2018 and passed the environmental impact assessment audit.
Honeywell, founded in 1906, in Wabash, Indiana is manufacturer of automotive parts, building technologies, and performance and safety materials for aerospace, The company's product portfolio includes electronic guidance systems, cockpit instrumentation, lighting, automotive parts, and primary propulsion and secondary power turbine engines. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. Their headquartere is located in Carolina and they have global sales offices and distributions channels.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Jigs chemical |
17.7%
|
| 2 | Central Drug House |
9.7%
|
| 3 | Amerigo Scientific. |
9.7%
|
| 4 | Oxford Lab Fine Chem LLP |
8.1%
|
| 5 | Parchem |
8.1%
|
| 6 | Honeywell |
8.1%
|
| 7 | KANTO CHEMICAL CO.,INC. |
6.5%
|
| 8 | LONGCHANG CHEMICAL |
4.8%
|
| 9 | MUBY CHEMICALS |
4.8%
|
| 10 | Junsei Chemical Co.,Ltd. |
4.8%
|
Derivation Method
The ranking is calculated based on the click share within the phenolphthalein page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 50.0% |
|
Japan
|
3 | 30.0% |
|
United States of America
|
2 | 20.0% |
