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This section provides an overview for phenylacetic acids as well as their applications and principles. Also, please take a look at the list of 15 phenylacetic acid manufacturers and their company rankings. Here are the top-ranked phenylacetic acid companies as of December, 2024: 1.Nilkanth Organics, 2.Spectrum Chemical Mfg. Corp., 3.Atul Ltd.
Table of Contents
Phenylacetic acid is an organic compound consisting of a methyl group of acetic acid with one hydrogen atom replaced by a phenyl group.
Its molecular formula is C8H8O2, and its CAS number is 103-82-2.
It has a molecular weight of 136.15, a melting point of 76-77°C, and a boiling point of 265.5°C. At room temperature, it exists as a white solid and has a characteristic odor. This odor is unpleasant when the concentration is high, but when the concentration is low, the substance has a honey-like aroma and is sometimes used in perfumes.
It has a density of 1.081 g/mL and is soluble in ethanol, ether, and hot water. Phenylacetone can be synthesized from Phenylacetic acid, but phenylacetone is a raw material for methamphetamine and amphetamine.
As mentioned above, the distribution of phenylacetic acid is strictly regulated by the Methamphetamine Control Law. Legitimate uses include use as an ingredient in perfumes and as a pharmaceutical raw material.
It is known to be contained in fruits and plants as auxin (a plant hormone that stimulates plant growth). It is also present in plant essential oils such as peppermint oil, rose oil, and neroli oil, and is used in perfumes for its characteristic scent.
In light concentrations, the substance is described as having a honey-like aroma. It is also used as a fragrance in soap in the form of esters. A typical application as a pharmaceutical raw material is in the synthesis of penicillin G.
Penicillin G is a strongly effective antibiotic against bacteria such as streptococci and meningococci, and is a historically important compound in the treatment of infectious diseases.
In terms of stability, phenylacetic acid may be altered by light. Under storage conditions, high temperatures and direct sunlight are conditions that should be avoided.
In addition, when storing the product, it is necessary to avoid mixing with strong oxidizing agents. Decomposition products include carbon monoxide and carbon dioxide.
Phenylacetic acid is sold as a chemical for organic synthesis, as a reagent product for research and development, and as an industrial chemical product. However, as a raw material for methamphetamine, it is subject to the Methamphetamine Control Law.
For this reason, it is difficult to actually obtain these products even if they are commercialized, and in many cases the manufacturers themselves do not have them in stock. Due to these regulations, special facilities are also required for storage and management after obtaining the product.
As an industrial chemical, it is manufactured in fiber drum packaging in 25 kg, 50 kg, and other capacity units.
Phenylacetic acid is obtained by hydrolysis of benzyl cyanide. From benzyl cyanide, 2-phenylacetamide is first formed, and further hydrolysis yields phenylacetic acid.
Phenylacetic acid is relatively easy to synthesize, but as mentioned above, it is forbidden to synthesize without permission. For engineers engaged in organic synthesis, it is important to understand and design synthesis to avoid unintentional formation.
Phenylacetic acid is strictly prohibited by the Methamphetamine Control Law because, as mentioned above, it is a raw material for methamphetamine, amphetamine, and other stimulants. The purpose of the Methamphetamine Control Law is to "implement necessary controls on the import, export, possession, manufacture, transfer, receipt, and use of the actual substance and its raw materials in order to prevent health and sanitary hazards caused by the abuse of methamphetamine."
A certificate of designation as a researcher of methamphetamine raw materials is required for handling, and violations are punishable by imprisonment for up to 10 years (import, export, and manufacture of methamphetamine raw materials) or up to 7 years (possession, transfer, receipt, and use of methamphetamine raw materials).
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Berjé Inc. was originally founded in 1949 and is headquartered in Carteret, New Jersey. The company is a national wholesaler of over 2000 essential oils and aromatic chemicals sourced from local farmers around the world. The company has two product categories: essential & fixed oils and aromatic chemicals. Essential & fixed oils include essential oils and fixed oils while aromatic chemicals include natural aromatics and all aromatic chemicals. The company lists chemicals by four application categories which are flavor ingredients, fragrance ingredients, functional ingredients, and fragrances.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Nilkanth Organics, established in 1996 and headquartered in Mumbai, India, is a manufacturer and supplier of organic chemicals. The company is engaged in offering various types of chemicals, including Sodium Compound Chemicals, Industrial Chemicals, Inorganic Chemicals, and Pharmaceutical Intermediates such as Acetyl Chloride, and Acetone. The chemicals provided by them comply with international norms and standards. Their products serve various industries, such as consumer products, industrial materials, and healthcare applications.
Atul Ltd was founded in 1947 and is headquartered in Valsad, India, as a diversified manufacturer of chemicals. The company's varied manufacturing portfolio has gained recognition in the business. This is a chemical firm that concentrates on continuous improvement. The organization aims to establish a work environment that constantly upholds and fosters its core ideals while ensuring that these standards are not compromised in pursuit of short-term benefits. The company has consistently delivered products and services of superior quality, establishing itself as the chosen partner in its business.
Sheetal Chemicals is an Indian manufacturer and supplier of industrial and specialty chemicals that was established in Mumbai, Maharashtra in 1997. The company produces various chemical products including industrial chemicals (e.g. solvents), active pharmaceutical ingredients (APIs), and specialty chemicals like catalysts and pesticides. It also offers imported chemicals such as hydroquinone and benzoyl chloride. Sheetal Chemicals chiefly serves clients in India’s agricultural and pharmaceutical sectors, as well as its pigments and dyes industry.
Forbes Pharmaceuticals was founded in 1980 and is headquartered in Maharashtra, India. The company is a manufacturer, trader, supplier, and exporter of a wide assortment of specialty chemicals that are used in a diverse range of industries. The company conducts research and development in-house to continually increase product offerings at a lower cost to consumers. The company’s product categories include various organic and inorganic compounds as well as chemical supplies including sulfates, nitrates, nitrites, carbonates, and oxides.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Ernesto Ventós S.A. is a company that was established in 1916 in Sant Just Desvern, Spain, specializing in distributing aroma compounds and essential oils to the fragrance and flavoring industries. Ventós is a company that has established solid commercial partnerships with significant raw material producers. As a result, they have become a distinguished agent or distributor of goods for these producers. The company has a wide range of over three thousand products, allowing them to offer efficient just-in-time service to their clients.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Nilkanth Organics |
13.5%
|
| 2 | Spectrum Chemical Mfg. Corp. |
12.5%
|
| 3 | LobaChemie Pct.Ltd. |
9.4%
|
| 4 | Atul Ltd |
9.4%
|
| 5 | Forbes Pharmaceuticals |
7.3%
|
| 6 | Premier Group Of Industries |
6.3%
|
| 7 | Sheetal Chemicals |
6.3%
|
| 8 | Parchem |
6.3%
|
| 9 | Cayman Chemical Company |
5.2%
|
| 10 | GLPBIO Technology LLC |
5.2%
|
Derivation Method
The ranking is calculated based on the click share within the phenylacetic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
7 | 53.8% |
|
United States of America
|
5 | 38.5% |
|
Spain
|
1 | 7.7% |
