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This section provides an overview for pyridoxine as well as their applications and principles. Also, please take a look at the list of 5 pyridoxine manufacturers and their company rankings. Here are the top-ranked pyridoxine companies as of December, 2024: 1.Healthy Life Pharma Private Limited, 2.Wellona Pharma, 3.Cayman Chemical Company.
Table of Contents
Pyridoxine is a water-soluble B vitamin.
It is relatively stable in heat and acidic conditions, but is easily degraded by light in neutral and alkaline conditions, so it is generally handled as pyridoxine hydrochloride with enhanced stability. Pyridoxine hydrochloride is also known as pyridoxine hydrochloride. Other derivatives are registered in the cosmetics field. The product is a white to light yellow crystalline powder that is soluble in water and insoluble in ethanol. Its melting point is approximately 206°C.
Pyridoxine is used primarily in the following three applications:
Pyridoxine is used in the prevention and treatment of vitamin B6 deficiency as well as in the following cases:
Pyridoxine is also used as a food additive, as pyridoxine hydrochloride. It is added to adjusted milk powder and flour to fortify them with vitamin B6, and is also used in confectionery, beverages, and other foods with an added healthy image.
Pyridoxine hydrochloride and pyridoxine trishexyldecanoate are used in cosmetic applications, each with different uses.
Pyridoxine Hydrochloride
Pyridoxine hydrochloride is used in cosmetics for its sebum inhibitory effect. It is used in hair conditioning agents to control excessive sebum secretion and in skin care products to prevent shiny skin.
Pyridoxine Trishexyldecanoate
Pyridoxine trishexyldecanoate is a vitamin B6 derivative consisting of isopalmitic acid attached to three hydroxy groups of pyridoxine. It is a liquid, oil-soluble substance with high skin penetration.
Filaggrin is a protein found in the stratum corneum. When the skin lacks moisture, filaggrin collects keratin, a protein that forms the framework of the stratum corneum, and plays a central role in the function of creating a moisturizing stratum corneum. Pyridoxine trishexyldecanoate is thought to promote the production of filaggrin, thereby acting to retain moisture in the skin.
Pyridoxine exists in animal cells as phosphorylated pyridoxal phosphate (PLP) or pyridoxamine phosphate (PMP) bound to enzyme proteins. During cooking and processing, and after entering the stomach as food, most PLP and PMP are released, hydrolyzed, and absorbed through the gastrointestinal tract.
On the other hand, pyridoxine 5ʼ β-glucoside (PNG) is present in living plant cells and is partially hydrolyzed in the digestive tract, where it is absorbed in its hydrolyzed form. Once absorbed, Pyridoxine is used as a cofactor in a variety of reactions in the body. The main roles of pyridoxine are as follows:
The recommended intake of Pyridoxine is 1.4 mg/day for men and 1.1 mg/day for women over 18 years of age.
Pyridoxine is known to cause a distinct adverse effect called sensory neuropathy, which is observed when several grams per day are consumed for several months. It is a sensory disorder of the nerves that transmit sensations in the body and internal organs.
Many foods contain Pyridoxine. Animal foods include red fish, meat, and liver. Plant foods contain pyridoxine, such as bananas, peppers, seaweed, and sesame seeds.
Pyridoxine deficiency in the normal diet is rare. However, some drugs for tuberculosis and antidepressants inhibit the absorption of Pyridoxine.
Pyridoxine deficiency can cause dermatitis, seizures, immune compromise, and anemia. In severe cases, glossitis, mouth ulcers, and mental confusion may occur.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Healthy Life Pharma Private Limited, headquartered in Mumbai, India, and established in 1977, serves as both a manufacturer and distributor of a diverse range of pharmaceutical formulations. The company is dedicated to providing an array of products, including anti-depressants for the central nervous system, vitamin and nutrition products, dry syrups, pre-filled syringes, anti-fungal and anti-protozoal drugs and more, catering to healthcare needs. The company serves numerous countries across Africa, LATAM, and Asia.
Wellona Pharma, founded in 2016 and headquartered in Surat, Gujarat, India, is a manufacturer and a distributor of pharmaceutical finished formulations. Its extensive product line comprises tablets, capsules, injections, creams, and ointments, offering diverse medication delivery methods. Wellona Pharma caters to an array of therapeutic areas, spanning antibiotics, antivirals, antifungals, vitamins, and more. The company operates state-of-the-art manufacturing facilities with accreditations such as WHO-GMP and ISO 9001:2015. These facilities are equipped with advanced, ultramodern technology.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Healthy Life Pharma Private Limited |
20.0%
|
| 2 | Wellona Pharma |
20.0%
|
| 3 | Cayman Chemical Company |
20.0%
|
| 4 | MilliporeSigma |
20.0%
|
| 5 | nacalai |
20.0%
|
Derivation Method
The ranking is calculated based on the click share within the pyridoxine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
2 | 50.0% |
|
United States of America
|
1 | 25.0% |
|
Japan
|
1 | 25.0% |
