This section provides an overview for picoline as well as their applications and principles. Also, please take a look at the list of 12 picoline manufacturers and their company rankings. Here are the top-ranked picoline companies as of November, 2024: 1.KANTO CHEMICAL CO.,INC., 2.KOEI CHEMICAL CO., LTD., 3.nacalai.
Table of Contents
Picoline, or methylpyridine, has the chemical formula C6H7N and a molecular weight of 93.13 g/mol. Found in bone oil and coal tar, picoline has three isomers: 2-picoline (2-methylpyridine), 3-picoline (3-methylpyridine), and 4-picoline (4-methylpyridine), also known respectively as o-picoline, m-picoline, and p-picoline.
2-picoline serves as a raw material for polymers, pharmaceuticals, and dyes, including tire cord adhesives. 3-picoline is key in producing nicotinamide and insecticides, while 4-picoline aids in synthesizing isonicotinic acid. Picoline isomers are also components in solvents, disinfectants, and vulcanization accelerators.
All picoline isomers are water, ethanol, and ether soluble. They react with metal salts and hydrogen halides to form additional compounds, and their oxidation or reduction leads to various pyridine derivatives. These isomers are colorless liquids with a pyridine-like odor, showing weak basicity. Their physical properties, such as density, melting, and boiling points, vary slightly among the isomers.
2-picoline, isolated from coal tar in 1846, is now primarily synthesized from acetaldehyde and ammonia. 3-picoline is industrially produced from ammonia and acrolein, with chichibabin pyridine synthesis as an alternative method. 4-picoline is obtained using ammonia and acetaldehyde with oxide catalysts.
2-picoline is a precursor to 2-vinylpyridine and the nitrification inhibitor nitrapyrine. Oxidation can produce picolinic acid. 3-picoline's ammoxidation yields 3-cyanopyridine, leading to agricultural chemicals like chlorpyrifos. 4-picoline, through ammoxidation, produces 4-cyanopyridine, a precursor to pharmaceuticals including the tuberculosis drug isoniazid.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Corey Organics was founded in 1994, and its headquarters is in Telangana, India, as a manufacturer of Active Pharmaceutical Ingredients (APIs), registered Pharma Intermediates, Fine Chemicals and Pyridine Derivatives for catering to the domestic as well as international market. Corey Organics has robust manufacturing facilities, and the company's management is commended to individuals with extensive experience and competence in manufacturing bulk medicines and the corresponding intermediates. This tactical approach ensures the delivery of superior products and fosters strong business relationships with clients across the globe.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Jubilant Ingrevia Limited, established in 2019, is headquartered in Uttar Pradesh, India and operates as a manufacturer and supplier of life science goods and solutions, catering to pharmaceutical, nutritional, agrochemical, and industrial sectors. The company provides a diverse selection of premium ingredients utilized across various sectors. The company's offering also includes specialized development and manufacturing services exclusively tailored to pharmaceutical and agrochemical clients. The organization is motivated by the objective of enhancing the quality of life for a large number of individuals via the implementation of ground-breaking solutions and advanced technology.
KOEI CHEMICAL CO. LTD. established in 1917 and based in Tokyo, Japan, is a manufacturer and supplier specializing in the production of chemical products. The company's product portfolio includes ionic liquids, amines, formalin products, pyridines, and pyrazines. These chemicals are utilized in various sectors, including pharmaceuticals, agricultural chemicals, electronics, furniture manufacturing, and the paint and coatings industry. The company is ISO 9001 and ISO 14001 certified, and provides custom synthesis and technical support to its clients.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | KANTO CHEMICAL CO.,INC. |
23.9%
|
2 | KOEI CHEMICAL CO., LTD. |
15.2%
|
3 | nacalai |
15.2%
|
4 | Jubilant Ingrevia Limited |
13.0%
|
5 | Jinan Qinmu Fine Chemical Co.,Ltd. |
8.7%
|
6 | A. B. Enterprises |
6.5%
|
7 | Manus Aktteva Biopharma LLP |
4.3%
|
8 | Central Drug House |
4.3%
|
9 | Otto Chemie Pvt. Ltd |
4.3%
|
10 | Corey Organics |
2.2%
|
Derivation Method
The ranking is calculated based on the click share within the picoline page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 6 | 60.0% |
Japan | 3 | 30.0% |
China | 1 | 10.0% |