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This section provides an overview for nonivamide as well as their applications and principles. Also, please take a look at the list of 20 nonivamide manufacturers and their company rankings. Here are the top-ranked nonivamide companies as of December, 2024: 1.Alomone Labs, 2.Kishida Chemical Co.,Ltd., 3.AVANSCURE LIFESCIENCES PVT. LTD.
Table of Contents
Nonivamide is a capsacinoid.
When it is distributed as a research reagent, the alias "nonivamide" is often used. It is present as a powdery solid at room temperature and is white to light reddish yellow in color.
Capsanoids are naturally occurring in peppers (capsaicin, dihydrocapsaicin, nordihydrocapsaicin, etc.) and also synthetically obtained, and nonivamide is one of these synthetic capsanoids.
Nonivamide, like capsaicin, is highly irritating to the skin and mucous membranes. Powdered nonivamide is likely to generate dust, and measures against inhalation and skin contact should be taken when using this product.
Nonivamide, like capsaicin, has a warming effect, making it useful as a warming agent in compresses and poultices. Poultices, poultices, and liquids containing nonivamide are characterized by a sensation of warmth in and around the area to which they are applied.
The compositional formula of nonivamide is represented by C17H27NO3. The basic properties (molecular weight, solubility) of Nonivamide are as follows:
Nonivamide binds to receptors called TRPV1 channels, which are abundantly distributed in the skin and mucous membranes; the original function of TRPV1 channels is to generate action potentials upon sensing stresses such as high temperature or inflammatory products.
However, when capsaicinoids such as nonivamide bind to TRPV1 channels, action potentials are generated even in the absence of high temperature or inflammatory products, which are perceived as heat when transmitted to the brain.
For this reason, when capsaicinoids adhere to the skin, the skin feels a tingling sensation, as if it has been exposed to something hot. In addition, the TRPV1 channel is essentially a sensor for biological defense in response to burns and inflammation. Therefore, stimulation by capsaicinoids also triggers a response to protect the body from burns and inflammation.
Specifically, these reactions include vasodilation and increased heart rate to send immune cells efficiently in the blood to the affected area. These reactions promote blood circulation and give the body the sensation of being warmed up.
Nonivamide has a similar molecular structure to capsaicin, another capsaicinoid. Capsaicinoids are characterized by an amide bond structure of vanillylamine and fatty acids. Depending on the difference in the structure of the fatty acid, properties such as polarity and the intensity of skin irritation differ.
The IUPAC name for capsaicin is "8-methyl-N-vanillyl-trans-6-nonenamide," which is an amide bond of 8-methyl-6-nonenoic acid and vanillylamine. On the other hand, nonivamide is an amide bond of nonanoic acid (perargonic acid) and vanillylamine.
When capsaicin is synthesized, a small amount of nonivamide may be generated as a byproduct. Since unintentionally generated, nonivamide may remain in the product, foods and medicines using capsaicin or capsicum extracts may be tested for the content of nonivamide for quality control purposes.
Due to skin and mucous membrane irritation, gloves, goggles, and other protective equipment should be worn when handling. As with capsaicin, inhalation may cause symptoms such as severe coughing and a burning sensation in the throat, requiring the use of masks and measures to prevent dispersal due to wind or static electricity.
Skin irritation may also occur when exposed to laboratory equipment that has been contaminated with nonivamide. Laboratory equipment should be washed immediately and surfaces rinsed with a solvent such as ethanol, which is soluble in nonivamide.
Because it is a non-water soluble substance, rinsing with ethanol is more effective than with water if it comes in contact with skin. If irritation persists in the eyes or throat, medical attention should be sought.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Sinco Pharmachem, founded in 2005 and headquartered in Shanghai, China, is a manufacturer and supplier of pharmaceutical intermediates and fine chemicals. The company specializes in producing various complex and high-purity organic compounds. These products are used in industries such as pharmaceuticals, agrochemicals, universities, and science institutions. It is utilized in the synthesis of various medications and agrochemicals. The company follows API standards in its drug development to ensure safety and environmental protection.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
China Qingdao Hong Jin Chemical Co., Ltd, established in 1997 in Qingdao, China, is a manufacturer and supplier of various chemicals and metals. The company has received REACH Full Registration for its CS powder, and operates from multiple manufacturing bases in Shandong, Hebei, Jiangsu and so on. Its bases specialize in production and contract manufacturing. Its product range includes liquid crystals for display technologies, electroceramics formulated powder for electronic applications, flame retardants, floatation reagents for mining, and feed additives.
Avanscure Lifesciences Private Limited, established in 2012 and based in Gurugram, Haryana, India is a manufacturer of active pharmaceutical ingredients. The company manufactures pharmaceutical nutraceuticals, vitamins, food additives, amino acids, and anti-cancer drugs. It is located in the industrial areas of Gurugram and doubles up as a supplier and trader of industrial and laboratory chemicals. It caters to the health and wellness industry, with a special importance on oncology, hormones and peptides. The company has a modern chemical processing unit, where superior technology is used to process chemicals like Amiodarone, Hydrochloride, Acetazolamide, and Bethanechol chloride.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Shaanxi Rebeccia, founded in China, is a supplier of plant extracts, herbal active ingredient separation, and traditional Chinese herbal medicine functional compound research. The company's product portfolio includes standardized herb & plant extracts, active pharmaceutical ingredients, beta-nicotinamide mononucleotide (NMN), health products raw materials, and natural food & cosmetics ingredients. Its products are used in pharmaceuticals, dietary supplements, and natural cosmetics. The company has three production lines with over 100 plant extracts and an annual production capacity of over 500MTS.
Transo-Pharm USA (TPUSA) is a GMP compliant distributor of active pharmaceutical ingredients (APIs) for the health and veterinary industries established in 2002 as a subsidiary of the German company Transo-Pharm Handelsgesellschaft GmbH. Located in Blue Bell, Pennsylvania, the company offers APIs for human use, veterinary drugs and medicines, as well as biotechnology products and therapies. TPUSA also provides logistical and customer support, as well as regulatory compliance services such as supplying drug master files (DMFs) and certificates of suitability (CEPs) for clients within the US market.
MuseChem Chemicals is an American chemical supplier located in Fairfield, New Jersey. They offer a wide range of products, including inhibitors and agonists, active pharmaceutical ingredients (APIs), and specialty chemicals. Research chemicals such as chemical reagents, bioactive chemicals, catalysts, and ligands are also part of their product offerings. MuseChem provides various services, including custom synthesis research of organic compounds for the agrochemical, chemical, and pharmaceutical industries. They also offer peptide synthesis services, ranging from bulk API peptides production to complex peptide modifications. Moreover, MuseChem offers bioconjugation services to create functional biomolecules for biomarker imaging, protein biodistribution, and cellular event tracking.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Alomone Labs |
20.0%
|
| 2 | Kishida Chemical Co.,Ltd. |
20.0%
|
| 3 | AVANSCURE LIFESCIENCES PVT. LTD |
10.0%
|
| 4 | Pharmaffiliates |
10.0%
|
| 5 | CHINA QINGDAO HONG JIN CHEMICAL CO.,LTD |
10.0%
|
| 6 | BioCrick |
10.0%
|
| 7 | MedChemExpress |
10.0%
|
| 8 | KANTO CHEMICAL CO.,INC. |
10.0%
|
Derivation Method
The ranking is calculated based on the click share within the nonivamide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 41.7% |
|
China
|
3 | 25.0% |
|
Japan
|
2 | 16.7% |
|
India
|
1 | 8.3% |
|
Germany
|
1 | 8.3% |
