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This section provides an overview for dehydrocholic acids as well as their applications and principles. Also, please take a look at the list of 15 dehydrocholic acid manufacturers and their company rankings. Here are the top-ranked dehydrocholic acid companies as of December, 2024: 1.Hangzhou Longshine Bio-Tech Co.,LTD, 2.Manus Aktteva Biopharma LLP, 3.ChemScence.
Table of Contents
Dehydrocholic acid, also known as dehydicholic, is an organic compound. This odorless, white to slightly yellow solid is soluble in ethanol but almost insoluble in water.
Dehydrocholic acid is a semi-synthetic bile acid derived from the oxidation of cholic acid found in bovine bile. It serves as a cholecystokinin, aiding in digestion by increasing bile volume and components.
As an amphiphilic molecule, dehydrocholic acid not only functions as a medication but also as an emulsifier, enhancing the solubility of other drugs in water.
Dehydrocholic acid is utilized in medical treatments related to digestion and lipid absorption, notably in conditions like cholangiohepatitis and bile duct disorders, to enhance bile secretion. It also plays a role in lipid digestion by activating enzymes such as lipase.
While effective, its use can lead to side effects including diarrhea and abdominal discomfort, necessitating cautious application.
Additionally, its amphiphilic nature allows for its use as an emulsifier in drug formulations, making fat-soluble drugs easier to disperse in aqueous solutions.
Dehydrocholic acid, a secondary bile acid, aids in lipid absorption and digestion by activating certain enzymes. Its structure, featuring a hydrophilic carboxyl group and a hydrophobic carbon skeleton, allows it to emulsify lipids effectively.
This acid dissolves readily in organic solvents, highlighting its potential as an additive in pharmaceutical formulations.
Dehydrocholic acid's steroid-based structure, adorned with carboxyl groups, grants it hydrophilic properties. This structural characteristic underpins its ability to emulsify lipids, blending water and oil components effectively.
Dehydrocholic acid production involves the oxidation of cholic acid, utilizing either chemical synthesis with oxidizing agents or biological methods via specific microorganisms.
1. Chemical Synthesis
This method uses oxidizing agents like hydrogen peroxide to convert cholic acid into dehydrocholic acid.
2. Biological Production
Microorganisms capable of transforming cholic acid into dehydrocholic acid are cultured, with the resulting acid extracted and purified from the culture medium.
Ensuring the purity of dehydrocholic acid requires effective separation and purification techniques, such as chromatography.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
ICE S.p.a., founded in 1949 and headquartered in Reggio Emilia, Italy, is a manufacturer specializing in active pharmaceutical ingredients, with a particular interest in Ursodeoxycholic Acid (UDCA), a vital component for treating liver diseases and gallstones. The company offers a comprehensive and diverse product portfolio, which includes plant-origin bile acids and carbohydrate derivatives, oral liquid, and solid finished dosage forms. These pharmaceutical ingredients serve numerous critical functions, including acting as selective inhibitory agents in bacteriological media, aiding in the treatment of gastrointestinal disorders and chronic dermatoses, supporting medical research and clinical development, and facilitating fat solubilization and digestion.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Hangzhou Longshine Bio-Tech Co., Ltd., established in 2011 and headquartered in Hangzhou, Zhejiang, China, is a manufacturer and supplier of pharmaceutical and chemical goods. The company offers a wide range of products, including API and intermediates, conjugated estrogens, beta-alanine, adrenaline tartrate, and 5-bromopyridine-2-carbaldehyde. These chemical products serve various purposes, such as being potent orally active estrogen receptor antagonists with anticancer properties, regulating animal physiology, diagnosing animal diseases, and providing treatments for conditions like erectile dysfunction.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Hangzhou Longshine Bio-Tech Co.,LTD |
33.3%
|
| 2 | Manus Aktteva Biopharma LLP |
16.7%
|
| 3 | ChemScence |
16.7%
|
| 4 | Spectrum Chemical Mfg. Corp. |
16.7%
|
| 5 | Junsei Chemical Co.,Ltd. |
16.7%
|
Derivation Method
The ranking is calculated based on the click share within the dehydrocholic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
7 | 53.8% |
|
Japan
|
2 | 15.4% |
|
India
|
1 | 7.7% |
|
Italy
|
1 | 7.7% |
|
United Kingdom
|
1 | 7.7% |
|
China
|
1 | 7.7% |
