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This section provides an overview for methylsulfonylmethane as well as their applications and principles. Also, please take a look at the list of 6 methylsulfonylmethane manufacturers and their company rankings. Here are the top-ranked methylsulfonylmethane companies as of December, 2024: 1.Junsei Chemical Co.,Ltd., 2.KANTO CHEMICAL CO.,INC., 3.nacalai.
Table of Contents
Methylsulfonylmethane (MSM) is an organosulfur compound, characterized by a sulfone group bonded to two methyl groups. It presents as a white solid at room temperature, with a melting point of 108-111°C and a boiling point of 238°C. MSM is soluble in water, acetone, and ethanol, found naturally in various foods, human cartilage, muscles, skin, hair, and nails, and is noted for its analgesic and anti-inflammatory properties.
Methylsulfonylmethane is recognized for its role in protein, collagen, and keratin production, contributing to healthy collagen levels and alleviating pain and inflammation, such as joint and back pain. Its benefits, particularly in humans, remain under-researched, although its potential effects on arthritis have been explored in animal studies. MSM is also incorporated into cosmetics, lotions, and dietary supplements.
As a colorless liquid at room temperature, Methylsulfonylmethane is hygroscopic and demonstrates high polarity, making it soluble in water and organic solvents like methanol. Chemically stable, it resists decomposition at elevated temperatures and, despite containing sulfur, is odorless and has a bitter taste.
The molecular structure of methylsulfonylmethane includes two methyl groups attached to a sulfonyl group, lending the compound its polar nature. This polarity influences its intermolecular interactions and solubility.
Arthritis: Methylsulfonylmethane may inhibit joint tissue degradation and relieve rheumatic pain. A study involving knee osteoarthritis patients reported improved pain scores with a 12-week course of MSM.
Seasonal Allergic Rhinitis: Research indicates MSM's effectiveness in mitigating allergic rhinitis symptoms, without affecting histamine or IgE levels.
Interstitial Cystitis: Methylsulfonylmethane has been reported to alleviate symptoms of interstitial cystitis, a condition more prevalent among women in the U.S.
Methylsulfonylmethane is produced by oxidizing dimethyl sulfoxide (DMSO) with hydrogen peroxide. Post-reaction, MSM is isolated through distillation and then spray-dried to form a crystalline powder.
Generally considered safe, MSM's side effects are minimal when used appropriately. However, its safety for pregnant women, nursing mothers, and topical applications requires further information. Caution is advised regarding the intake levels specified on U.S. imports.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Junsei Chemical Co.,Ltd. |
36.4%
|
| 2 | KANTO CHEMICAL CO.,INC. |
21.2%
|
| 3 | nacalai |
15.2%
|
| 4 | Merck |
15.2%
|
| 5 | MilliporeSigma |
6.1%
|
| 6 | FUJIFILM Wako Pure Chemical Corporation |
6.1%
|
Derivation Method
The ranking is calculated based on the click share within the methylsulfonylmethane page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 100.0% |
