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This section provides an overview for diglyme as well as their applications and principles. Also, please take a look at the list of 22 diglyme manufacturers and their company rankings. Here are the top-ranked diglyme companies as of December, 2024: 1.Columbus Chemical Industries, 2.Toronto Research Chemicals, 3.MUBY CHEMICALS.
Table of Contents
Diglyme, or diethylene glycol dimethyl ether, is an organic compound known for its use as a high-boiling-point hydrophilic electron donor solvent in synthetic organic chemistry. Its chemical formula is C6H14O3, indicating its structure as two methoxylated ethylene glycol molecules. It is recognized and classified under various safety laws due to its toxicity and potential hazards.
Figure 1. Example of Diglyme Coordination to Grignard Reagents
Diglyme serves various roles, including as a diluent, detergent, and reaction solvent, particularly with Grignard reagents and metal compounds. Its chelating ability to metal cations enhances reaction rates, making it valuable in reactions such as hydroborination with diborane.
Figure 2. Basic Information on Diglyme
With a molecular weight of 134.18, diglyme is a clear, colorless liquid at room temperature, featuring a melting point of -68°C and a boiling point of 162°C. It is miscible with water and various organic solvents, displaying stability under basic conditions but reacting violently with strong oxidants.
Available for both research and industrial applications, diglyme is sold in volumes from 25mL to 500mL for R&D and in larger containers like 16 kg cans and 200 kg drums for industrial use. Some formulations may include stabilizers such as BHT or contain minor impurities like water.
The synthesis involves the reaction between dimethyl ether and ethylene oxide in the presence of an acid catalyst, leading to diglyme's production.
Figure 3. Example of Reaction Using Diglyme as a Solvent
Utilized for its ability to chelate metal cations, diglyme is a preferred solvent in various synthetic reactions, including reductions and hydroborination-amination processes.
As a hazardous substance, diglyme requires careful handling, appropriate protective equipment, and adherence to safety regulations due to its flammability and health risks.
*Including some distributors, etc.
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Sankyo Chemical Co. LTD., established in 1957 and headquartered in Nagoya, Japan, is a manufacturer of several intermediate materials, including paints, industrial cleaning agents, thinners, organic industrial chemicals, and adhesives. The products can be used in several areas, including silk screen printing, wiping off resin, washing agents for flux, metal processing, and mold forming. The company accepts contract manufacturing and provides several environmentally friendly products that comply with ISO 14001, the Industrial Safety and Health Law, and the PRTR (Pollutant Release and Transfer Register) Law.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Columbus Chemical Industries, based in Columbus, Wisconsin, USA, is a manufacturer and distributor of specialty chemicals. The company offers chemical analysis, problem-solving skills, and chemical packaging and processing services for high-purity and ultra-pure chemical needs of several industries such as the pharmaceutical, semiconductor, and energy industry. Its product range include nitric acid, salts, and chemical solvents, which can be packaged in bottles, drums, or in high capacity totes. The company operates under an ISO 9001:2015 certified Quality Management System and is a member of the National Association of Chemical Distributors.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Hridaan Pharma Chem is a manufacturer of organic solvents, inorganic chemicals, and specialty chemicals, established in 2002 and headquartered in Mumbai, India. Their product range includes organic solvents such as methanol, ethanol, and isopropanol, inorganic chemicals such as sulfuric acid and nitric acid, and specialty chemicals such as flavoring agents and electronic chemicals. These products serve diverse industries with applications ranging from pharmaceuticals, plastics, and water treatment to food flavoring, fragrance, and electronics manufacturing. Hridaan Pharma Chem holds the Trust Seal Verified, indicating that the company has been authenticated and verified by IndiaMART.
Prasol Chemicals Limited., founded in 1992 and headquartered in Mumbai, India, is a manufacturer of acetone & phosphorous based speciality chemicals. The company initially began manufacturing phosphorous-based chemicals and later diversified into acetone-based chemistry, creating an integrated value chain across its product line. The majority of its products consist of acetone and phosphorous derivatives, which find their end uses in pharmaceuticals, agrochemicals, and the home and personal care segments. The company has a government of India certified export House and a global distribution network across Asia, North America and the European Union.
Oxford Lab Fine Chem LLP (OLFC) is an Indian manufacturer and exporter of laboratory chemicals as well as intermediates established in 2015 following the merger of Oxford Lab Chem and Oxford Laboratory. Based in Mumbai, Maharashtra, the company’s extensive chemical portfolio includes various bases, acids, standards, solutions, and buffers. These are offered in different grades, such as AR/GR and HPLC. OLFC primarily supplies the industrial processes of clients in the pharmaceutical and chemical processing sectors in over 40 countries, as well as in India’s educational and laboratory institutions.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Shree Sadguru Enterprise, established in 1995 and headquartered in Ankleshwar, Gujarat, India, is a manufacturer and supplier of chemical products and solutions. The company specializes in providing basic raw materials, pharma raw materials, and specialty chemicals. These products find applications in various industries, including pharmaceuticals, chemicals, and manufacturing. The company adheres to quality standards and is certified by ISO 9001 and ISO 14001, ensuring quality management systems and environmental safety and responsibility.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ataman Kimya, established in 2006, is a distributor of chemicals based in Istanbul, Turkey. Their wide range of products includes detergents, cosmetics, disinfectants, pharmaceutical chemicals, and water treatment chemicals. They also offer textile, leather, paper, and mining chemicals. These chemicals, such as hydrogenated castor oils, ethanol, and butylene glycol, find applications in various industries, such as personal care, household cleaning, fragrance, coatings, and agriculture. The company also offers custom blending to meet specific requirements.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Columbus Chemical Industries |
20.6%
|
| 2 | Toronto Research Chemicals |
14.7%
|
| 3 | MUBY CHEMICALS |
14.7%
|
| 4 | KANTO CHEMICAL CO.,INC. |
8.8%
|
| 5 | Shree Sadguru Enterprise |
5.9%
|
| 6 | A. B. Enterprises |
5.9%
|
| 7 | OXFORD LAB FINE CHEM LLP |
5.9%
|
| 8 | Merck |
5.9%
|
| 9 | Hridaan Pharma Chem |
2.9%
|
| 10 | Prasol Chemicals Limited. |
2.9%
|
Derivation Method
The ranking is calculated based on the click share within the diglyme page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 46.2% |
|
Japan
|
5 | 38.5% |
|
Canada
|
1 | 7.7% |
|
United Kingdom
|
1 | 7.7% |
