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This section provides an overview for cycloheximide as well as their applications and principles. Also, please take a look at the list of 21 cycloheximide manufacturers and their company rankings.
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Cycloheximide is an antibiotic with a range from colorless to light brown, known for its use in biochemical research due to its ability to inhibit protein synthesis in eukaryotic cells. Its IUPAC name is 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione, and it is also referred to as actidione, naramycin A, or U-4527.
Primarily used in vitro due to its toxicity, cycloheximide inhibits eukaryotic protein synthesis by blocking tRNA and mRNA movement on the ribosome. It's notable for its quick action and reversibility. Cycloheximide does not affect mitochondrial protein synthesis, aiding in distinguishing between mitochondrial and cytoplasmic protein origins.
Though its use has declined due to toxicity concerns, Cycloheximide has been employed as a plant growth regulator, pesticide, and antifungal agent for specific plant diseases. It's used in various applications, including beer fermentation cultures to inhibit bacterial contamination.
Cycloheximide, with the chemical formula C15H23NO4 and a molecular weight of 281.35, is solid at room temperature. It is soluble in organic solvents and moderately soluble in water, with stability varying across different pH levels.
Produced naturally by streptomyces griseus, cycloheximide is obtained as a by-product of streptomycin production through fermentation.
Cycloheximide is subject to strict regulatory controls due to its hazardous nature, including requirements for labeling, notification, and precautions for handling and storage under various national laws and regulations.
Precautions include avoiding strong oxidizers, using local exhaust ventilation during handling, and specific methods for fire extinguishing. Cycloheximide should be kept in light-shielded, sealed containers in a cool, well-ventilated area.
*Including some distributors, etc.
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Cepham Life Sciences, founded in 2013, and located in Fulton, Maryland, is a manufacturer of life science research products. The company offers a diverse range of bioscience research products including assay kits, ELISA kits, antibodies, recombinant proteins, and enzymes. They specialize in products for areas like Cell Metabolism, Proliferation, Stress, Damage, and Repair. Its portfolio also includes biochemicals, buffers, reagents, catering to academic research, drug discovery, and clinical labs. Stringent quality control is conducted at their advanced facilities in Maryland and New Jersey, USA.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
AG Scientific, established in 1997 and headquartered in San Diego, United States, is an ISO 9001:2015-certified supplier of biochemicals and pharmaceutical materials for medical devices, preclinical research, bioprocessing, and diagnostic applications. The company offers a wide range of reagents and other products for molecular biology and diagnostic test development, including antibiotics, biochemicals, enzymes, inhibitors, buffers, and more. The company's products enable scientists to continue making life-changing discoveries in research centers, biotechnology companies, and pharmaceutical companies around the world.
Isoltema Group, founded in 1952 in Gambetolla, Italy, is a manufacturer of self-adhesive products for the building trade. The company’s products include flashing tapes, sealing tapes & strips, waterproofing membranes, and butyl drums which find ideal uses in waterproofing, repair, permanent sealing, as well as in emergency situations. Its products are served to various markets, including automotive, energy, marine, and piping industries. The company has been awarded a bronze medal for its EcoVadis rating in 2023.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
EMD Chemicals Inc. is a manufacturer of chemicals for the purpose of application and laboratories and related industries that is headquartered in Gibbstown, New Jersey, and was founded in 1970. The company serves a product line revolving around pharma biotechnology, diagnostics, and industries for life science; healthcare includes oncology, neurology, immunology, fertility, and general medicine; electronics includes solutions for semiconductors, displays, and surfaces. The company serves industry markets ranging from biosciences, food, cosmetics, pharmaceuticals, and LCD displays.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Hangzhou Longshine Bio-Tech Co., Ltd., established in 2011 and headquartered in Hangzhou, Zhejiang, China, is a manufacturer and supplier of pharmaceutical and chemical goods. The company offers a wide range of products, including API and intermediates, conjugated estrogens, beta-alanine, adrenaline tartrate, and 5-bromopyridine-2-carbaldehyde. These chemical products serve various purposes, such as being potent orally active estrogen receptor antagonists with anticancer properties, regulating animal physiology, diagnosing animal diseases, and providing treatments for conditions like erectile dysfunction.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Merck Millipore, founded in 1954 and headquartered in Darmstadt, Germany, is a manufacturer, distributor, and supplier of life science products and services. Their diverse range of products finds applications in research, development, and manufacturing of biotechnological and pharmaceutical drug therapies. Some of their offerings include filters for removing contaminants from liquids and gases, chromatography columns for separating and analyzing complex mixtures, reagents used in various laboratory assays, antibodies for detecting and quantifying specific molecules, and cell culture media for growing and maintaining cells in culture. Their products and services are utilized significantly in the advancement of life sciences and drug development.
naugraexport was established in 1951 and is a distributor and supplier of lab equipments based in Ambala Cantt, Haryana, India. The company's product portofolio offers various products such as zoom stereo binocular microscope, human anatomy models, flask erlenmeyer narrow neck glass, laser theodolite, and precision engineered cube mould. The products are used in various industries such as petrochemical, agriculture, semiconductor manufacture, pharmaceutical, and energy. The company has obtained the certificate of ISO 9001:2008 certification standards.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Cell Signaling Technology, established in 1999 and headquartered in Danvers, Massachusetts, is a life sciences company developing products for other researchers. The company offers nature biotechnology, cell, journal of immunology, and biological chemistry research. It is effective in applied systems biology research, particularly as it relates to cancer, and understands the importance of using antibodies. All of its antibodies undergo rigorous validation for multiple applications to ensure efficiency in research. It also provides technical support, methodologies, and guidance for solid research outcomes.
AdooQ BioScience, founded in 2006 and headquartered in Irvine, California, is a supplier specializing in purity inhibitors, chemical probes and reference compounds. The company's product portfolio includes inhibitors for signaling pathways, epigenetics, apoptosis, stem cells, and proteins. These products serve as tools for researchers in academia as well as the biotechnology and pharmaceutical industries, facilitating the execution of experiments, exploration of diseases, and the potential development of treatments and therapies. The company has established over 25 distributors in 30 different countries, along with service networks spanning five continents, thereby ensuring a worldwide reach.
Tocris Bioscience, trading as Tocris Cookson Ltd., established in 1982 and headquartered in Bristol, UK, is a supplier of life science reagents. Its extensive product range encompasses receptor agonists and antagonists, enzyme inhibitors, ion channel modulators, fluorescent probes and dyes, along with PROTAC Degraders for targeted protein degradation. The compay has received several accolades, including The Queen's Awards for Enterprise in International Trade. The company is part of the life science division of Bio-Techne, which also includes class brands R&D Systems, Novus Biologicals, ProteinSimple and Advanced Cell Diagnostics.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
6 | 42.9% |
|
India
|
2 | 14.3% |
|
Italy
|
1 | 7.1% |
|
Switzerland
|
1 | 7.1% |
|
Japan
|
1 | 7.1% |
|
Germany
|
1 | 7.1% |
|
China
|
1 | 7.1% |
|
United Kingdom
|
1 | 7.1% |
