This section provides an overview for sodium salicylate as well as their applications and principles. Also, please take a look at the list of 16 sodium salicylate manufacturers and their company rankings. Here are the top-ranked sodium salicylate companies as of November, 2024: 1.Manus Aktteva Biopharma LLP, 2.MUBY CHEMICALS, 3.Parchem.
Table of Contents
Lecturer, Department of Oral and Maxillofacial Surgery, Nagasaki University Hospital
Graduated from Kyushu University School of Dentistry in 2003, Doctor of Dentistry. Lecturer at Nagasaki University Hospital since 2018. Specializes in oral surgery.
Japan Society of Oral and Maxillofacial Surgery Instructor / Specialist, Japan Certified Doctor of the Society of Stomatology.
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Sodium salicylate, with molecular formula C7H5NaO3 and molecular weight 160.10, is a compound of salicylic acid with a sodium salt, and is a white crystal or crystalline powder at room temperature. It is extremely soluble in water, soluble in acetic acid (100), and slightly soluble in ethanol (95).
It is characterized by gradual coloration by light, and thus by sunlight and air, and especially by exposure to ammonia gas.
Industrially, it is obtained by synthesizing sodium phenoxide and carbon dioxide at high temperatures and pressures. Also called sodium salicylate, it is decomposed by heating to produce oxygen dioxide.
Sodium salicylate has long been used in medicine for its anti-inflammatory and analgesic properties. It is particularly applicable to symptomatic neuralgia (nerve pain with an obvious cause, such as trauma, pressure, inflammation, or infection) that tends to occur in limbs and joints.
It is also used as a denaturant and preservative in cosmetics. In the case of cosmetics, the amount of sodium salicylate that can be contained is small, so it is not a major problem.
However, those with a history of hypersensitivity to salicylic acid compounds (such as aspirin) may experience flare-ups of allergic symptoms such as asthma. It may also aggravate symptoms in patients with ulcerative colitis and Crohn's disease.
In animal studies, teratogenic effects and weak ductus arteriosus contraction in fetuses have been reported, so pregnant women are advised to reduce the dosage due to the possibility of fetal effects.
Sodium salicylate liberates salicylic acid in acidic solutions and precipitates with iron salts in neutral solutions, forming insoluble iron salicylate. It may also precipitate with alkaloid salts as insoluble salicylate alkaloid salts.
Discoloration occurs when mixed with alkalis, iron salts, and nitrites. Alkali bicarbonate turns reddish brown, and iron salts turn purple. The discoloration caused by iron salts does not change the therapeutic effect.
In aqueous solution, the alkali may cause photo-oxidation, resulting in coloration or precipitation, but this reaction is catalyzed by copper, iron, and manganese, and can be prevented by adding hydrogen sulfite or thiosulfate to the mixture.
Sodium salicylate is thought to exert its analgesic and anti-inflammatory effects by inhibiting cyclooxygenase and decreasing the synthesis of prostaglandins and thromboxane precursors from arachidonic acid, but this remains unclear. Unlike aspirin, however, it does not inhibit platelet aggregation.
The exact mechanism of action of its anti-inflammatory and analgesic effects is unknown. It is thought to exert its effects by inhibiting the synthesis of prostaglandins or other factors in inflammatory tissues, thereby blocking the generation of nerve impulses.
*Including some distributors, etc.
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Spectrum Laboratory Products, Inc., established in 1971 in New Brunswick, NJ, is a manufacturer and supplier of fine chemicals, laboratory supplies, APIs, and equipment that are ISO 9001:2015 certified. The company makes chemicals such as controlled substances, colorants, oils, flavors and fragrances, and bases. It also supplies capsule machines, glassware washers, ointment mills, compounding essentials, and syringes. Its New Jersey and California plants are FDA registered, while the China lab is ISO 17025 certified.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Powder Pack Chem was founded in 2001 and is headquartered in Mumbai, Maharashtra, India. The company is a manufacturer and exporter of specialty chemicals used in pharmaceuticals, fashion, and beauty products. The company offers hundreds of products available in volumes ranging from 100 grams to 500 kilograms. The company services include providing on-time consignments for customers in need of quick delivery. Chemicals range from acacia gum powder all the way to three variations of zinc sulphate.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
The Andhra Sugars Limited is a sugar manufacturer and supplier. Headquartered in Tanuku, India, the company was established in the year 1947. The company specializes in producing a wide array of products, including sugar, chemicals, and bio-products. The Andhra Sugars Limited puts energy on sustainability, hence operates across sectors such as food, pharmaceuticals, and renewable energy. Apart from its core products, the company offers services like waste management and energy generation, contributing to both economic growth and environmental responsibility.
MainChem Co., Ltd, established in 2014, is a Chinese manufacturer and distributor of fine and specialty chemicals, with its headquarters located in Xiamen, Fujian. The company's product portfolio includes life science chemicals, petrochemicals, and specialty chemicals. Some of MainChem’s chemical substances have passed evaluations based on Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), a European Union regulation. These chemicals are used in various industries, including cosmetics, food additives, personal care product, and water treatment. MainChem offers the "ONE-STOP" solution for chemical sourcing from China. They also provide custom chemical synthesis services, encompassing the entire process from initial research to commercial-scale production.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Manus Aktteva Biopharma LLP |
31.6%
|
2 | MUBY CHEMICALS |
26.3%
|
3 | Parchem |
10.5%
|
4 | The Andhra Sugars Limited. |
5.3%
|
5 | Alpha Chemica |
5.3%
|
6 | Powder Pack Chem |
5.3%
|
7 | Central Drug House |
5.3%
|
8 | KANTO CHEMICAL CO.,INC. |
5.3%
|
9 | Merck |
5.3%
|
Derivation Method
The ranking is calculated based on the click share within the sodium salicylate page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 5 | 45.5% |
United States of America | 3 | 27.3% |
Japan | 2 | 18.2% |
China | 1 | 9.1% |