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This section provides an overview for gluconic acid as well as their applications and principles. Also, please take a look at the list of 10 gluconic acid manufacturers and their company rankings. Here are the top-ranked gluconic acid companies as of December, 2024: 1.Surfachem Group Ltd, 2.United States Biological, 3.Alfa Chemistry.
Table of Contents
Gluconic acid is an organic compound with the chemical formula C6H12O7. It is an optically active compound, and only the D form occurs naturally.
It is also a type of aldonic acid (a derivative obtained by oxidizing monosaccharides, in which the formyl group at the 1-position of aldose is replaced by a carboxyl group).
The CAS registration numbers are 526-95-4 for the D form and 133-42-6 for the racemic form.
Gluconic Acid is used as a food additive because of its non-volatility and low acidity. Its main uses are as a pH adjuster for processed rice products, and as a seasoning and pH enhancer for various beverages, pickles, dressings, and sauces.
When used in foods, it is labeled as an acidifier, an hydrogen ion concentration adjuster, a pH adjuster, or gluconic acid.
Potassium gluconic acid and sodium gluconic acid, which are salts of gluconic acid, are also used as food additives.
For example, they are used to replace the processing function of salt in the manufacture of bread, soy sauce, etc. It is also used as a taste improver for the sweetener sodium saccharin.
In the medical field, it is mainly used as a medicine for iron deficiency. The incorporated gluconic acid ions effectively facilitate the absorption of metal ions in the body.
Calcium gluconic acid ointment is also effective in the treatment of chemical wounds caused by hydrogen fluoride. Calcium ions taken up as gluconic acid salts have the ability to combine with soluble fluoride ions to form insoluble calcium fluoride, making it non-toxic.
Salts with quinine are used as a malaria treatment in the form of intramuscular injections, and zinc salts are substances used to castrate male dogs.
In industry, gluconic acid is sometimes used as a weak acid to remove precipitation of metal salts and to clean metals.
Gluconic Acid is a substance that readily dehydrates to the cyclic ester glucono-delta-lactone (D-(+)-gluconic acid-δ-lactone) when dissolved in an acidic solution. Dehydration also readily occurs when attempting to isolate free acids from solution.
In aqueous solution, it exists as an equilibrium mixture with this compound, so the pure form can only be obtained in salt form.
It is also a strong chelating agent and works particularly well in alkaline solutions. Specifically, it is known to chelate calcium, iron, aluminum, copper and other heavy metal ions.
In nature, gluconic acid is particularly abundant in honey and royal jelly. Other sources include soybeans, rice, shiitake mushrooms, and fermented foods such as wine, soy sauce, and vinegar.
It is the only organic acid known to increase bifidobacteria. It has a soft sour taste and is corrosive and irritating.
Gluconic Acid has a molecular weight of 196.155, a melting point of 131 °C, and is a colorless crystal at room temperature. It has a density of 1.23 g/mL and an acid dissociation constant pKa of 3.86. It is readily soluble in water. Its solubility in water is 316 g/L.
Gluconic Acid has a carboxyl group at the end of its six-carbon chain and five hydroxy groups, one on each of the second through sixth carbon atoms.
Gluconic Acid is sold mainly as a reagent for research and development and as an industrial raw material. Both are usually aqueous solutions of about 50%.
R&D reagent products are available in 25g, 500g, and other capacities. They are offered in capacities that are easy to handle in the laboratory.
When the term gluconic acid is used without any declaration, it usually refers to D-gluconic acid.
When sold as an industrial raw material, it is usually supplied as a raw material for food additives such as acidifiers and pH adjusters, etc. It is sold in large volumes such as 20 kg or 250 kg to meet demand at factories. This also usually refers to D-gluconic acid.
Gluconic Acid is produced in the phosphogluconic acid pathway, one of the metabolic pathways of glucose in vivo. The reduced form of glucose is the sugar alcohol sorbitol, whereas the oxidized form of glucose is the sugar acid gluconic acid.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
United States Biological, located in Salem, Massachusetts, is a manufacturer and supplier of life science research products. Its product offerings include biochemicals, antibodies, and molecular biology kits. The company’s products are used in various fields such as genomic research, biotechnology, and pharmaceutical development. Products are available from affordable research quantities to larger bulk amounts for process development and production. Its customer base comprises pharmaceutical and biotechnology companies both in the US and overseas.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
ViVoChem, established in 2006 and based in Almelo, the Netherlands, is a chemical manufacturer and supplier operating under BÜFa Gmbh & Co. Kg (BÜFa Group). The company's offerings include chemical raw materials supplied to the adhesive, agricultural, food, personal care, and paint industries. It also offers solutions related to chemical raw material handling, storage, and distribution. The company’s drumming facilities, complete with intermediate bulk containers (IBCs), facilitate chemical packaging. It also operate a warehouse facility, complying with Accord Dangereux Routier (ADR) regulations for hazardous substances. Moreover, the company conducts chemical distribution through truck cargos and provides assistance in chemical export processes.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Surfachem Group Ltd. is a 2M Group company established in 1981 and based in West Yorkshire, UK, distributor of surfactant and specialty chemical ingredients. The company's extensive products include pharmaceutical excipients, surface additives, fabric conditioners, defoaming agents, and anti-oxidants used in industrial, household and personal applications. The products are also beneficial in agricultural applications for controlling pests and manufacturing human medicines and medical devices in pharmaceutical companies. The company also offers assistance with regulatory issues, improve product performance, logistical expertise and technical services.
California Chemical, founded in 2018 and headquartered in Costa Mesa, California, is a supplier of chemical products. Its product portfolio includes ammonium bifluoride, calcium chloride, boric acid, bonderite, and carbomer used in pharmaceutical, construction, car care, aerospace, and mining. It also helps firms select the right chemicals and ingredients for manufacturing nutraceuticals as well as water purification procedures. The company provides diverse services, including local warehousing, labelling, hazmat logistics, chemical distribution, and management.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Surfachem Group Ltd |
30.2%
|
| 2 | United States Biological |
15.1%
|
| 3 | Alfa Chemistry |
11.3%
|
| 4 | Vivochem |
9.4%
|
| 5 | Spectrum Chemical Mfg. Corp. |
9.4%
|
| 6 | Santa Cruz Biotechnology, Inc. |
9.4%
|
| 7 | BOC Sciences |
7.5%
|
| 8 | California Chemical |
3.8%
|
| 9 | MilliporeSigma |
1.9%
|
| 10 | KANTO CHEMICAL CO.,INC. |
1.9%
|
Derivation Method
The ranking is calculated based on the click share within the gluconic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 42.9% |
|
Japan
|
1 | 14.3% |
|
Netherlands
|
1 | 14.3% |
| United States | 1 | 14.3% |
|
United Kingdom
|
1 | 14.3% |
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Sanyo Life Material
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50%glucon acid (liquid) Organic acids (hydrapic acid, citric acid, sodium citrate, glucon acid, Sodium gluconate (sodium gluconate), gluconodertala...
