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This section provides an overview for griseofulvin as well as their applications and principles. Also, please take a look at the list of 11 griseofulvin manufacturers and their company rankings. Here are the top-ranked griseofulvin companies as of December, 2024: 1.AdvaCare Pharma USA, 2.Manus Aktteva Biopharma LLP, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Griseofulvin is a white crystalline powder.
Griseofulvin is an aromatic compound with the chemical formula C17H17ClO6, molecular weight 352.77, and CAS number 126-07-8. The IUPAC name of Griseofulvin is (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione.
Griseofulvin was discovered in 1939 by Oxford et al. at the University of London in a soil fungus called penicillium griseofulvum. It was subsequently isolated by Bryan et al. in 1946 and identified by Grove et al. in 1947.
Griseofulvin is used as an antifungal agent.
The mechanism of action of griseofulvin is that it acts on the fungal cytoskeleton, inhibiting cell division and thereby preventing fungal growth.
Griseofulvin was once used as an oral drug in Japan. However, Griseofulvin is no longer manufactured and marketed in Japan due to side effects such as headache and dizziness, low drug prices, and the introduction of other antifungal drugs.
Griseofulvin has a melting point of 218-222°C, a boiling point of 570°C, and a density of 1.4 g/cm3. Griseofulvin is insoluble in ethanol, acetone, and benzene, and insoluble in water. Griseofulvin can be extracted with chloroform from penicillium griseofulvum fungi or their cultures.
A new drug that exhibits similar antifungal effects to griseofulvin is terbinafine, which is known to be effective for a shorter period than griseofulvin. On the other hand, it may be more effective than terbinafine for some scalp infections.
Side effects of taking griseofulvin include allergic reactions, nausea, diarrhea, headache, sleep disturbances, and fatigue. It is not recommended for people with liver failure or porphyria. If taken during pregnancy or in the months before pregnancy, it may harm the unborn baby.
Griseofulvin is obtained industrially by fermentation of the fungus penicillium griseofulvum. The biosynthesis of griseofulvin begins with the synthesis of a six-carbon poly β-keto chain, which undergoes kleisen condensation, aldol condensation, and cycloaromatization to form the benzophenone intermediate. Further methylation, halogenation, and phenol oxidation followed by O-methylation of the tetrahydrofuranone species produced by radical coupling and stereoselective reduction of the olefin yields Griseofulvin.
Griseofulvin is exempt from all major domestic laws and regulations.
Precautions for handling and storage are as follows.
*Including some distributors, etc.
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AdvaCare Pharma USA LLC, founded in 2014, is an American pharmaceutical manufacturer and supplier based in Cheyenne, Wyoming. The company specializes in a wide range of products, including over-the-counter (OTC) medicines, supplements, antimalarial tablets, injections, and oral suspensions. They also offer oncology tablets, injections, and powder for injections, as well as veterinary products and medical devices like injection instruments, diagnostic detection instruments, and skin and wound care products. AdvaCare's products are available under various brands, such as AmoxiCare™ for amoxicillin capsules and AdvaLife™ for supplements.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Devlife Corporation Private Limited, headquartered in Mumbai, India, and established in 2005, is an exporter and manufacturer of customized finished formulations and Micronesian bulk drugs. The company offers an array of product lines featuring various dosage forms, including soft gelatin capsules, allopathic cough syrup, pain relief drugs and pharmaceuticals, large-volume parenterals, and liquid injectables. The company caters to various segments of the life science industry, including biotech, clinical research, and pharmaceutical sectors. It is one of the WHO GMP injection manufacturers in India.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Healthy Life Pharma Private Limited, headquartered in Mumbai, India, and established in 1977, serves as both a manufacturer and distributor of a diverse range of pharmaceutical formulations. The company is dedicated to providing an array of products, including anti-depressants for the central nervous system, vitamin and nutrition products, dry syrups, pre-filled syringes, anti-fungal and anti-protozoal drugs and more, catering to healthcare needs. The company serves numerous countries across Africa, LATAM, and Asia.
Wellona Pharma, founded in 2016 and headquartered in Surat, Gujarat, India, is a manufacturer and a distributor of pharmaceutical finished formulations. Its extensive product line comprises tablets, capsules, injections, creams, and ointments, offering diverse medication delivery methods. Wellona Pharma caters to an array of therapeutic areas, spanning antibiotics, antivirals, antifungals, vitamins, and more. The company operates state-of-the-art manufacturing facilities with accreditations such as WHO-GMP and ISO 9001:2015. These facilities are equipped with advanced, ultramodern technology.
Taj Pharmaceuticals Limited, established in 1995 and headquartered in Mumbai, India, is a global manufacturer and supplier of generic medicines, healthcare, and other products. The company markets more than 500 branded and 4600 generic compositions to consumers in over 40 countries and territories across the globe. Its products cover a vast array of therapeutic categories, and offers an extensive range of dosage forms and delivery systems including oral solids, controlled-release, and steriles. Some of its offerings are diabetic care products, insulin, and growth hormones. The company holds the ISO 9001:2000 certification for its quality management system.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | AdvaCare Pharma USA |
26.6%
|
| 2 | Manus Aktteva Biopharma LLP |
15.2%
|
| 3 | MilliporeSigma |
13.9%
|
| 4 | KANTO CHEMICAL CO.,INC. |
13.9%
|
| 5 | Central Drug House |
8.9%
|
| 6 | Healthy Life Pharma Private Limited |
6.3%
|
| 7 | Devlife Corporation Private Limited |
5.1%
|
| 8 | NATIONAL ANALYTICAL CORPORATION |
3.8%
|
| 9 | A.S. lifesciences |
2.5%
|
| 10 | Wellona Pharma |
2.5%
|
Derivation Method
The ranking is calculated based on the click share within the griseofulvin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
8 | 80.0% |
|
United States of America
|
1 | 10.0% |
|
Japan
|
1 | 10.0% |
