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This section provides an overview for glyoxal as well as their applications and principles. Also, please take a look at the list of 16 glyoxal manufacturers and their company rankings. Here are the top-ranked glyoxal companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.IRO GROUP INC., 3.Alpha Chemica.
Table of Contents
Glyoxal is a dialdehyde compound with the molecular formula C2H2O2.
Its IUPAC nomenclature is ethanediyl, and it is also known as oxalic aldehyde.
It has a molecular weight of 58.04, a melting point of 15°C, and a boiling point of 51°C. At room temperature, it is colorless to pale. At room temperature, it exists as a colorless to pale yellow liquid. In the solid state, it is a yellow columnar crystal.
With a density of 1.27 g/cm3, it is soluble in water and organic solvents, and is often handled in a 40% aqueous solution.
Glyoxal is used as a cross-linking agent in the field of resin and fiber manufacturing due to its ability to cross-link polymer compounds with hydroxyl groups (e.g., polyvinyl alcohol). The use of glyoxal as a cross-linker can reduce water solubility and help in surface processing.
In R&D, glyoxal is also used as a denaturing agent in electrophoresis and blotting reagents and in reagents for polyacrylamide gel electrophoresis (PAGE). Glyoxal is useful in RNA electrophoresis because of its ability to dissolve the secondary structure of RNA.
Other applications include pharmaceuticals, fragrances, and other organic synthesis materials, soil hardeners, paper finishers, and deodorants. Glyoxal is also produced in the autoxidation of glucose or the peroxidation of lipids and is known to be present in a variety of foods and tobacco smoke.
Glyoxal has the property of quickly absorbing moisture and polymerizing into a white powder in air. Therefore, it is mostly handled in aqueous solution.
In aqueous solution, glyoxal is present in the form of hydrates or hydrate oligomers, and therefore has little volatility or odor. The flash point of a 40% aqueous solution is over 100℃. The pH range is 2.1 to 2.7.
In terms of reactivity, it is a mutagenic substance that binds specifically to guanine residues in DNA. In vivo, glyoxal, along with methylglyoxal, is responsible for the formation of terminal glycation products by reacting with guanidine groups.
Currently, glyoxal is generally sold primarily as an R&D reagent product. Basically, it is not sold as a stand-alone product, but as a 40% aqueous solution.
Product volume types include 500 mL and 500 g. The product is offered in volumes that are easy to handle in the laboratory. The product is handled as a reagent that can be stored at room temperature.
As mentioned above, it is a hazardous substance that is both flammable and mutagenic. When handling it, it is required to comply with various laws and regulations and to handle it safely.
Glyoxal can be synthesized by catalytic oxidation of ethylene glycol or by the oxidation of acetylene with ozone or air in the presence of oxygen and copper catalysts. Alternative synthesis methods include the oxidation of paraldehyde with selenite and the oxidation of acetaldehyde with nitric acid.
*Including some distributors, etc.
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Silver Fern Chemical is a US-based chemical supplier, established to source and distribute a diverse range of hard-to-find industrial chemicals. The company was founded in 2004 and is headquartered in Dallas, Texas. With extensive industry experience, the company offers a wide spectrum of chemicals for various applications, including adhesives, coatings, and personal care products. Silver Fern Chemical boasts excellent logistics solutions, expertise, and products that meet the demands of its customers. The company serves many industries including agriculture, specialty chemical manufacturers, personal care, coatings and adhesives food and pharmaceutical, as well as household and industrial cleaning.
TRInternational Inc., founded in 1994 and headquartered in Edmonds, Washington, is a supplier of ingredients, raw materials, and services in North America. Its diversified product portfolio includes chemicals, rubber, and paints used in industries like metalworking, water treatment, and industrial cleaning. It has over 20 stocking and import points across the United States and offers additional services like custom manufacturing, contract packaging, and proprietary formulation. The company is SBA, WOSB, and LGBTBE certified, and in 2018, it was ranked number 70 in the Top 100 Chemical Distributors in North America.
Univar Solutions is a distributor and supplier of chemicals and ingredients since 1924 and are headquartered in Downers Grove, Illinois. The company provides a wide range of chemicals to customers and extends its value-added services to suppliers. The services include data sharing, digital marketing, lab and formulation capabilities, and more. As providers of chemicals their inventory is limitless with stocks of acids, enzymes, oxides, silicates, additives, and other ingredients and they offer packaging, product development, and custom blending besides the supplies. Overall industries like Food, Agriculture, Mining, Home and Industrial Cleaning, Pharmaceuticals, and lots more benefit from Univar Solutions.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Pearl Chemicals, established in 2014 and headquartered in Ludhiana, Punjab, India, operates as a supplier of various chemicals. Its product range encompasses a wide array of offerings, including industrial acids, organic chemicals, water treatment chemicals, chemical solvents, and chemical powders. Among its product catalog are items like Formic Acid, Ethyl Carbitol, Bisphenol A, Dicyandiamide, and Hydroxylamine Sulphate, which serve diverse industries such as manufacturing, processing, and repackaging. The company specializes in meeting clients' chemical procurement needs and tailoring solutions to specific requirements.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
14.3%
|
| 2 | KANTO CHEMICAL CO.,INC. |
11.1%
|
| 3 | IRO GROUP INC. |
9.5%
|
| 4 | Alpha Chemica |
9.5%
|
| 5 | MUBY CHEMICALS |
7.9%
|
| 6 | Silver Fern Chemical |
7.9%
|
| 7 | Covalent Chemical |
6.3%
|
| 8 | Pearl Chemicals |
4.8%
|
| 9 | Parchem |
4.8%
|
| 10 | TRInternational, Inc. |
4.8%
|
Derivation Method
The ranking is calculated based on the click share within the glyoxal page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
6 | 46.2% |
|
India
|
5 | 38.5% |
|
Japan
|
2 | 15.4% |
