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This section provides an overview for potassium guaiacol sulfonate as well as their applications and principles. Also, please take a look at the list of 11 potassium guaiacol sulfonate manufacturers and their company rankings. Here are the top-ranked potassium guaiacol sulfonate companies as of December, 2024: 1.SimSon Pharma Limited, 2.Conscientia Industrial Co., Ltd, 3.Zhejiang Haizhou Pharmaceutical Co., Ltd..
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1993~2019: Engaged in pharmaceutical research and development and analysis of various biological samples at the Pharmaceutical Research Institute of Japan Kayaku Co., Ltd. He is also in charge of facility management as a dangerous goods handler and radiation handling chief.
2019: Moved to another company in the same industry and has been in charge of similar work until now.
He also writes, translates, and edits specialized books.
Linkedin: https://www.linkedin.com/in/makoto-niwa-25331040/
Researchmap: https://researchmap.jp/0000-0002-2355-1222/
Potassium guaiacol sulfonate is a compound with expectorant properties.
It is also called potassium 4-hydroxy-3-methoxy benzene sulfonate (IUPAC nomenclature) and sulfoguaiacol. -8, and 78247-49-1.
The compositional formula is C7H7KO5S, but some commercial products clearly state that it is 1/2 hydrate (C7H7KO5S - 0.5H2O).
Potassium guaiacol sulfonate is primarily used as an ingredient in OTC drugs. It promotes airway secretion and decreases the viscosity of sputum, making it easier to expectorate, and it also has a weak antiseptic action.
For this reason, it is often one of the ingredients in common cold remedies and antitussives/expectorants. It is an ingredient that makes it easier to produce so-called "phlegm that gets stuck in the throat."
Normally, guaiacol sulfonate exists in the form of a white crystalline powder. It is easily soluble in water, but somewhat insoluble in methanol and insoluble in ethanol and ether.
Its aqueous solution is slightly acidic, with a pH of 4.0-5.5 in a 5 w/v% solution. The melting point is 231-232°C. It is a chemically stable compound, but the powder is hygroscopic. It may also be altered by light, so light shielding is required for storage.
Potassium guaiacol sulfonate has positional isomers. Potassium guaiacol sulfonate (potassium 4-hydroxy-3-methoxybenzenesulfonate), the expectorant discussed in this section, has a sulfonic acid group (potassium salt) at position 1, a methoxyl group at position 3, and a phenolic hydroxyl group at position 4, out of the three carbons in the benzene ring.
However, it is not clear from the names "potassium guaiacol sulfonate," "potassium guaiacolsulfonate," or "sulfogaiacol" which position isomer (which part of guaiacol is sulfonic acid).
Therefore, it is necessary to check carefully whether what you are purchasing is potassium 4-hydroxy-3-methoxybenzenesulfonate. Potassium 3-hydroxy-4-methoxybenzenesulfonate is also available, although it is not widely distributed.
It was created in 1881 by the synthesis of a potassium sulfonate derivative from guaiacol. Since then, the method of production of potassium guaiacol sulfonate has been chemical synthesis. Generally, it is synthesized by sulfonation of guaiacol to obtain potassium guaiacol sulfonate, which is then converted to potassium salts.
Guaiacol was first isolated in 1826 from the guaiac resin (Gum guaicum or guaiac resin) obtained from the yuzu tree (Guaiacum officinale). In ancient times, guaiacol was also used as an expectorant.
However, as a general precaution for chemical substances, dust-protective masks and protective gloves should be worn and the substance should be handled in an environment with a local exhaust ventilation system. Also, avoid mixing with strong oxidizers.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
VIVAN Life Sciences Pvt. Limited, launched in 2010 in Maharashtra, India, is a manufacturer of chemical synthesis and product development products for pharmaceutical companies, contract manufacturing firms, university research labs, and contract research organizations. The company's product catalog includes building blocks, customized research chemicals, stable isotope labeled compounds, organoborane amine complexes, and specialized chemical manufacturing. It also provides custom synthesis services (CSS), chemical contract research (CCR), and contract manufacturing services. The company is accredited by CRISIL MSE 2, ISO 17034: 2016, ISO IEC 17025: 2005.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Zhejiang Haizhou Pharmaceutical Co., Ltd. was launched in 1970 in Yanhai Industrial Park, China, and is a manufacturer of pharmaceutical products, intermediates, and fine chemicals. The company's product catalog includes Guaifenesin, Potassium guaiacol sulfonate, Guaifenesin DC95, Azasetron hydrochloride, and Irsogladine maleate. It offers APIs like Methocarbamol, Anastrozole, Pyrazinamide, Atorvastatin calcium, and Marbofloxacin. The company also deals in intermediates such as Rosuvastatin, MRI contrast media, and Etoricoxib. It is OHSAS18001, ISO 9001/14001, and ISO/OHSAS certified.
Alps Pharmaceutical Ind. Co. Ltd., established in 1947 and headquartered in Hida-shi, Japan, functions as a global pharmaceutical product manufacturer. Its product line comprises of active pharmaceutical ingredients (APIs), veterinary APIs, food additives, and feed additives. The company adopts a strategic warehousing approach, maintaining the Okamae warehouse with an extensive capacity of 8,000 tons for both products and raw materials. This robust supply chain strategy allows them to effectively hedge against risks related to weather-induced crop failures, market price fluctuations, and procurement challenges.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
18.6%
|
| 2 | SimSon Pharma Limited |
16.3%
|
| 3 | Conscientia Industrial Co., Ltd |
9.3%
|
| 4 | Zhejiang Haizhou Pharmaceutical Co., Ltd. |
9.3%
|
| 5 | MedChemExpress |
9.3%
|
| 6 | MUBY CHEMICALS |
7.0%
|
| 7 | BOC Sciences |
7.0%
|
| 8 | Tokyo Chemical Industry Co., Ltd. |
7.0%
|
| 9 | Santa Cruz Biotechnology, Inc. |
7.0%
|
| 10 | VIVAN Life Sciences Pvt. Limited |
4.7%
|
Derivation Method
The ranking is calculated based on the click share within the potassium guaiacol sulfonate page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
3 | 37.5% |
|
United States of America
|
2 | 25.0% |
|
China
|
2 | 25.0% |
|
Japan
|
1 | 12.5% |
