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This section provides an overview for guaiacol as well as their applications and principles. Also, please take a look at the list of 26 guaiacol manufacturers and their company rankings. Here are the top-ranked guaiacol companies as of December, 2024: 1.Sandoo Pharmaceuticals and Chemicals Co.,Ltd, 2.Toronto Research Chemicals, 3.ADVANCED BIOTECH.
Table of Contents
Guaiacol is a type of phenol with a methoxy group, whose molecular formula is C7H8O2.
It is also called 2-hydroxyanisole, methylcatechol, and o-methoxyphenol. It is also described as guaiacol or guaiacol.
Guaiacol is a natural flavor compound produced by wine aged in oak barrels. Guaiacol and 2,4,6-trichloroanisole are said to be responsible for cork rot in wine.
Guaiacol is the main ingredient of creosote. Creosote is a mixture of phenols produced by distilling wood tar obtained from beech plants.
It has bactericidal and antiseptic properties and is used as an internal medicine for various types of diarrhea, intestinal fermentation, and food poisoning. It also has expectorant and antitussive effects and is used as a remedy for chronic bronchitis.
It can also be used as a synthetic raw material for fragrances due to its distinctive aromatic odor. It is also used as a regulator of vanillin, the raw material for the aroma of vanilla.
Guaiacol has a melting point of 28°C and a boiling point of 204-206°C. It has a characteristic odor and is a colorless to light yellow liquid or colorless crystalline solid. It is somewhat insoluble in water and miscible in methanol and ethanol.
Because of its toxic and irritating properties, accidental contact with the mucous membranes of the mouth requires immediate rinsing. The lethal dose for adults is 3-10 g.
Guaiacol has a methoxy group at the 2-position of phenol and is also called 2-methoxyphenol. Its molecular weight is 124.13 and its specific formula is 2-CH3OC6H4OH.
Guaiacol was first isolated by Otto Paul Unverdorben in 1826. Guaiacol can be synthesized by methylating o-catechol with potassium carbonate and dimethyl sulfate.
Guaiacol can be prepared in the laboratory in a variety of ways. Guaiacol is produced by the two-step hydrolysis of o-Anisidine, derived from anisole, via a diazonium derivative. Guaiacol can also be synthesized by the dimethylation of catechol and selective monodemethylation.
Guaiacol derived from biomass is a useful precursor for synthesizing a wide variety of compounds as "green fuels". For example, it is used to quantify peroxidase.
Peroxidase is an enzyme that can oxidatively cleave the peroxide structure into two hydroxyl groups. In the presence of hydrogen peroxide, peroxidase produces tetraguaiacol. Tetraguaiacol is a colored compound that can be quantified by absorbance at 420-470 nm.
The structural isomers of guaiacol that differ in the position of the substituent are 3-methoxyphenol and 4-methoxyphenol. 3-methoxyphenol has a methoxy group in position 3, while 4-methoxyphenol has a methoxy group in position 4.
3-Methoxyphenol is also called m-methoxyphenol, m-guaiacol, m-hydroxyanisole, 3-hydroxyanisole, resorcinol monomethyl ether
Mekinol, 4-hydroxyanisole, and para-guaiacol are other names for 4-methoxyphenol.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
ADVANCED BIOTECH, founded in Totowa, NJ, in 1993 is a manufacturer of Natural Flavors and Fragrances. The company's product portfolio includes Natural Aromatics, Natural Pyrazines, Essential Oils and Isolates that are used to produce scents and fragrances, and Organic Certified Products such as bath and body products, and home cleaning products. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Cosmetics and healthcare.
Vigon International is headquartered in East Stroudsburg, Pennsylvania, and is a subsidiary of Azelis. The company is a custom manufacturer of fragrances and flavor products used in cosmetics, food processing, and related industries. The company’s compounds originate from dozens of fruits, herbs, and spices grown in regions as diverse as California, Germany, Brazil, and Indonesia. The company’s custom processing capabilities include adding reaction flavors such as Maillard in batches from 1 to 5,000kg, vacuum distillations, essential oil folding and concentration, and emulsion production.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Sandoo Pharmaceuticals and Chemicals Co., Ltd., founded in 2009 and situated in Ningbo, Zhejiang Province, China, is a manufacturer of pharmaceuticals and chemicals. Its diverse product portfolio encompasses active pharmaceutical ingredients (API), anti-cancer substances, antiviral drug intermediates, fine chemicals, and food additives, along with critical intermediates for polypeptide compounds. The company maintains a stringent adherence to FDA-approved and GMP-certified sources for its supplies which are exported to over 20 countries.
Clean Science and Technology Limited, founded in India in 2006, is a manufacturer of specialty chemicals. The company offers 3 major segments including Performance Chemicals, Pharmaceutical Chemicals, and FMCG Chemicals. They are an essential ingredient in daily usage products catering to agricultural, cosmetic, aromas, and food industries. it has 3 manufacturing facilities and offers and also offers custom chemical formulations tailored to specific requirements. The company serves industries including chemical manufacturing, pharmaceutical and agriculture.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
HiMedia Laboratories Private Limited is a manufacturer of biochemicals, media, and other laboratory consumables that was established in 1975 and is headquartered in Kennett Square, Pennsylvania. Its product range includes bacterial media, cell culture media, biochemicals, enzymes, and reagents. The company's products are used by a number of industries, as diverse as biotechnology, pharmaceutical, diagnostics, and food and beverage industries. HiMedia also provides services to its customers such as custom manufacturing of microbiome sequencing where the company can custom manufacture products to meet the specific needs of its customers.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Sisco Research Laboratories Pvt. Ltd., established in 1975, is an Indian manufacturer and supplier of chemicals, biochemicals, and reagents, headquartered in Mumbai, Maharashtra. Supported by Food and Drug Administration (FDA)-approved manufacturing facilities, the company offers a range of products, including general laboratory chemicals and solvents, biochemical, bioreagents, and specialty fine chemicals. Their offerings also include animal cell culture, BioLit™ range of DNA and protein tools, and nanotechnology products. Additionally, SRL provides dehydrated culture media, biological ingredients, media supplements, chromogenic media, and media kits. These products serve diverse industries such as biotechnology, confectionary and food, personal care products, pharmaceuticals, and protein purification.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Flinn Scientific is an American manufacturer of science equipment, tools, and supplies established in 1977 and based in Batavia, Illinois. The company’s product list includes lab equipment, anatomy models, chemistry supplies, STEM tools (e.g. 3D printers), and educational software. It also offers safety equipment and resources, including eyewashes and showers, disposal supplies, personal protective equipment (PPE), and first aid kits. Flinn Scientific products are primarily used by clients in America's research and educational institutions, as well as in its healthcare sector.
Hangzhou Longshine Bio-Tech Co., Ltd., established in 2011 and headquartered in Hangzhou, Zhejiang, China, is a manufacturer and supplier of pharmaceutical and chemical goods. The company offers a wide range of products, including API and intermediates, conjugated estrogens, beta-alanine, adrenaline tartrate, and 5-bromopyridine-2-carbaldehyde. These chemical products serve various purposes, such as being potent orally active estrogen receptor antagonists with anticancer properties, regulating animal physiology, diagnosing animal diseases, and providing treatments for conditions like erectile dysfunction.
Wuhan Tianyuda Precision Machinery Co. Ltd., established in 2015 and headquartered in Wuhan, China, is a manufacturer and supplier of wrenches. The company's product range includes torque multipliers, torque wrench calibrators, and manual torque wrenches. These products are essential for precise torque measurement and adjustments in industries such as aviation, aerospace, automotive, electric power, and more. The company also provides services, including product consultation, after-sales support, and accessory provision to its customers.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Solvay was born in 1863 and is headquartered in Brussels, Belgium. The company is a producer of advanced materials and specialty chemicals to customers worldwide in several markets including the automotive, healthcare, aerospace, and electronics markets. The company’s product offerings range from amines to surfactants with kitting options available for certain materials such as film and tape process materials. The company sources many materials from renewable sources. The company’s cellulose acetate is produced from bio-sourced wood pulp from sustainably managed forests.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ernesto Ventós S.A. is a company that was established in 1916 in Sant Just Desvern, Spain, specializing in distributing aroma compounds and essential oils to the fragrance and flavoring industries. Ventós is a company that has established solid commercial partnerships with significant raw material producers. As a result, they have become a distinguished agent or distributor of goods for these producers. The company has a wide range of over three thousand products, allowing them to offer efficient just-in-time service to their clients.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Sandoo Pharmaceuticals and Chemicals Co.,Ltd |
11.4%
|
| 2 | Toronto Research Chemicals |
11.4%
|
| 3 | ADVANCED BIOTECH |
10.0%
|
| 4 | Vigon International |
10.0%
|
| 5 | Solvay SA |
7.1%
|
| 6 | Spectrum Chemical Mfg. Corp. |
5.7%
|
| 7 | Junsei Chemical Co.,Ltd. |
5.7%
|
| 8 | Cayman Chemical Company |
4.3%
|
| 9 | Molekula Americas LLC |
4.3%
|
| 10 | Clean Science and Technology Limited |
2.9%
|
Derivation Method
The ranking is calculated based on the click share within the guaiacol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 22.7% |
|
India
|
5 | 22.7% |
|
Japan
|
5 | 22.7% |
|
China
|
3 | 13.6% |
|
Canada
|
1 | 4.5% |
|
Belgium
|
1 | 4.5% |
|
United Kingdom
|
1 | 4.5% |
|
Spain
|
1 | 4.5% |
