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This section provides an overview for ornithine as well as their applications and principles. Also, please take a look at the list of 9 ornithine manufacturers and their company rankings. Here are the top-ranked ornithine companies as of December, 2024: 1.KYOWA HAKKO BIO CO.,LTD., 2.Fullscript, 3.Kishida Chemical Co.,Ltd..
Table of Contents
Ornithine is a special amino acid, one of the many types of amino acids that travels throughout the body with the blood.
It is especially active in the liver. Ornithine is found in all living things in nature, and one of the most famous ornithine-containing foods is whitebait. The reason why whitebait is said to be effective against hangovers is that the ornithine in whitebait inhibits fatigue caused by alcohol.
Ornithine has also been reported to promote the secretion of growth hormones and improve sleep. Ornithine is an amino acid that has a positive effect on the body.
The primary use of ornithine is as a dietary supplement to maintain the health of the body. It has few uses as an industrial raw material.
Ornithine is found in supplements and sometimes in nutritional drinks. Supplementation of ornithine, which is lacking in the daily diet alone, is expected to improve liver function, physical growth, and sleep.
Besides improving the liver's ability to detoxify ammonia, which is harmful to the body, ornithine consumption is likely to promote the secretion of growth hormones during sleep. Furthermore, it improves sleep quality by suppressing the secretion of stress hormones, which is expected to be beneficial for both genders.
Ornithine is a type of "free amino acid" that travels with the blood through the body. While most of the commonly known amino acids make up proteins, ornithine is not a protein-building amino acid. In other words, ornithine is not an amino acid that is present in the body to make protein; it is an amino acid that is free in the body.
Because ornithine is a naturally occurring substance, it is considered safe. However, taking too much ornithine is bad for the liver because it causes the liver to function excessively.
When taken in adequate amounts, ornithine can enhance liver detoxification, promote muscle synthesis, and reduce fatigue after exercise.
The molecular structure of ornithine is similar to that of citrulline and arginine, which are members of the same amino acid family. Ornithine, citrulline, and arginine are necessary for the reaction in the liver to convert toxic ammonia into urea. The reaction circuit that converts toxic ammonia to urea is called the ornithine circuit or urea cycle.
Toxic ammonia is produced after the breakdown of amino acids or after strenuous exercise. In the ornithine circuit, ammonia is first combined with ornithine to form citrulline. A further enzymatic reaction converts citrulline to arginine, which in turn yields urea. When urea is produced, ornithine is regenerated in the cycle.
Thus, ammonia, which is toxic in the body, reacts with ornithine in the liver and is converted to urea via citrulline and arginine. Therefore, a portion of the ornithine molecule has almost the same structure as a portion of each of the citrulline and arginine molecules. It is believed that ornithine facilitates the reaction of the ornithine circuit and thus enhances the detoxification function of the liver.
The main food with high ornithine content is shijimi clam, but other food sources include mushrooms such as shimeji mushrooms and eringi mushrooms, yellowfin tuna, flatfish, and cheese. Studies have reported that each ingredient contains about 20 mg of ornithine per 100 g. Shijimi contains about 20 mg, beech mushrooms contain about 140 mg, eringi mushrooms contain about 30 mg, and yellowfin tuna contains 2 to 7 mg.
Ornithine is not believed to have any major side effects, but excessive intake may cause abdominal pain or diarrhea. Do not take excessive amounts just because it seems to be good for you.
*Including some distributors, etc.
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Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
MuseChem Chemicals is an American chemical supplier located in Fairfield, New Jersey. They offer a wide range of products, including inhibitors and agonists, active pharmaceutical ingredients (APIs), and specialty chemicals. Research chemicals such as chemical reagents, bioactive chemicals, catalysts, and ligands are also part of their product offerings. MuseChem provides various services, including custom synthesis research of organic compounds for the agrochemical, chemical, and pharmaceutical industries. They also offer peptide synthesis services, ranging from bulk API peptides production to complex peptide modifications. Moreover, MuseChem offers bioconjugation services to create functional biomolecules for biomarker imaging, protein biodistribution, and cellular event tracking.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KYOWA HAKKO BIO CO.,LTD. |
62.5%
|
| 2 | Fullscript |
12.5%
|
| 3 | Kishida Chemical Co.,Ltd. |
12.5%
|
| 4 | KANTO CHEMICAL CO.,INC. |
12.5%
|
Derivation Method
The ranking is calculated based on the click share within the ornithine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 66.7% |
United States of America
|
2 | 33.3% |
