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This section provides an overview for aminopyrine as well as their applications and principles. Also, please take a look at the list of 6 aminopyrine manufacturers and their company rankings. Here are the top-ranked aminopyrine companies as of December, 2024: 1.MedChemExpress.
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Aminopyrine is a pyrazolone derivative, appearing as a colorless or white crystalline solid. It is used in a 13C-labeled aminopyrine breath test, a non-blood test for assessing the metabolic activity of cytochrome P450 in liver function tests.
Initially marketed by Hoechst as an antipyretic analgesic, aminopyrine works by inhibiting the synthesis of prostaglandins, which cause fever and pain and has analgesic properties due to its action on the hypothalamus. However, due to its side effects, including agranulocytosis and carcinogenic potential, it is no longer used as an antipyretic analgesic.
Aminopyrine is soluble in chloroform, ethanol, ether, and water, with a melting point of 225-228°F. It has a slightly bitter taste and no odor, and its chemical formula is C13H17N3O. The molecular weight is 231.29358, and it is sensitive to light, turning blue to purple in the presence of oxidants.
Aminopyrine was first synthesized in 1884 by Ludwig Knorr from antipyrine, hydrochloric acid, and sodium nitrite, and later refined by Wilhelm Filehne.
Aminopyrine is more potent than antipyrine, with a stronger analgesic effect than antipyrine and isopropylantipyrine.
Aminopyrine has been associated with agranulocytosis and nitrosation reactions in the gastrointestinal tract. The injectable form is currently used only in some veterinary drugs.
In the body, aminopyrine is bound to urea through glucuronidation, converted to rubazonic acid, and excreted in the urine, which appears reddish.
Aminopyrine is a pyrazolone derivative, a class of heterocyclic compounds with a five-membered ring lactam structure. Pyrazolone derivatives include antipyrine and isopropylantipyrine.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Biomol GmbH, founded in 1968 and headquartered in Heidelberg, Germany, is a manufacturer, supplier, and distributor of life science products for the biomedical research domain. The company's range of products includes primary antibodies that originate from different host species such as mouse, rabbit or goat, dyes and labeling reagents, qPCR gene family primers, as well as virus-based tools used to manipulate genetic material and study viral infections. These scientific resources find applications across various disciplines, including molecular biology, academic research of drug development, pharmaceutical development of antibodies, and clinical diagnostics of viral infections.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MedChemExpress |
50.0%
|
| 2 | MilliporeSigma |
50.0%
|
Derivation Method
The ranking is calculated based on the click share within the aminopyrine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 40.0% |
|
Canada
|
1 | 20.0% |
|
Germany
|
1 | 20.0% |
Spain
|
1 | 20.0% |
