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This section provides an overview for isopropylantipyrine as well as their applications and principles. Also, please take a look at the list of 6 isopropylantipyrine manufacturers and their company rankings. Here are the top-ranked isopropylantipyrine companies as of December, 2024: 1.Chemodex Ltd., 2.Ralington pharma LLP.
Table of Contents
Propyphenazone is a chemical compound with a molecular weight of 230.306 and the chemical formula C14H18N2O. It works by inhibiting the synthesis of prostaglandins.
It is known that the pain effects of bradykinin, a bioactive substance involved in inflammation and pain, are enhanced by prostaglandins. Propyphenazone inhibits the pain-enhancing effects of prostaglandins on bradykinin by blocking these prostaglandins.
As mentioned above, propyphenazone is used as an antipyretic analgesic because it inhibits the prostaglandin potentiating effect on bradykinin. It is not only used as a prescription drug, but is also widely used in over-the-counter cold remedies.
Side effects of propyphenazone have been reported to include shock, cutaneous mucous membrane eye syndrome, and toxic epidermal necrolysis. As a result, propyphenazone has been banned from production in several countries.
Propyphenazone has a melting point of 103°C-105°C, a boiling point of about 372°C, and is solid at room temperature. It is only slightly soluble in water, but is extremely soluble in acetic acid (100%), ethanol (96%), and methylene chloride. However, it is unstable to high temperatures, strong acids, and strong alkalis, and may decompose.
Pharmacologically, it exhibits antipyretic, analgesic, and anti-inflammatory effects by inhibiting prostaglandin synthesis. It also has an inhibitory effect on platelet aggregation. Prostaglandins are among the substances that cause headaches and menstrual cramps.
Propyphenazone also has antipyretic effects. It acts on the thermoregulatory center to dilate skin blood vessels and promote the dissipation of heat.
Propyphenazone is a compound with a pyrazolone skeleton, which has an isopropyl group and a benzene ring.
Pyrazolone is a compound with a five-membered ring structure, pyrazoline, from which one hydrogen atom has been replaced by a carbonyl group. Pyrazolines are heterocyclic compounds with nitrogen atoms in two adjacent positions of the five-membered ring.
The isopropyl group is an alkyl group in the form of propane (CH3CH2CH3) with one hydrogen removed from the center carbon. The "iso" in "isopropyl" means "branched at the end of the alkyl group."
The benzene ring is a ring structure consisting of six carbon atoms. Compounds with benzene rings are collectively called aromatic compounds. Therefore, pyrazolone is a type of aromatic compound.
Antipyretic analgesics like propyphenazone, whose basic skeleton is the pyrazolone skeleton, are known as pyrine antipyretic analgesics.
Pyrine-type antipyretic analgesics are effective and have a long duration of action, but they have side effects such of a rash (known as pyrine rash), edema, and hematopoietic disorders, so caution is required.
Shock, cutaneous mucous membrane eye syndrome, and toxic epidermal necrolysis have been reported as side effects of propyphenazone. For this reason, it is banned from production in several countries.
Countries where propyphenazone is banned include Sri Lanka, Malaysia, Thailand, and Turkey.
It is used in South America, Germany, Italy, Spain, India, Pakistan, Japan, Indonesia, etc
*Including some distributors, etc.
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SIELC Technologies is a specialized manufacturer and developer of high-performance liquid chromatography (HPLC) columns, devices, and systems. The company was founded in 2001 and is based in Illinois, with a network of partner distributors in over 30 countries across six continents. The company's product portfolio is centered around various HPLC columns including chiral, normal- and reverse-phase, ion-exchange, and mixed-mode models. These supply clients in the biotech, pharmaceutical, petrochemical, and cannabis industries.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Chemodex Ltd., established in 2001 and based in St. Gallen, Switzerland, is a manufacturer of fine chemicals, covering different fields such as reagents for life sciences, bioactive molecules, and organic pollutants. The company offers a range of products including fluorescent substances derived from fluorophores such as coumarin, rhodamine, and pyrene. These products are typically used as probes, stains, and in other applications by life-science researchers in academia, biotechnology, and the pharmaceutical industry. Its customer base includes small and medium businesses, large enterprises, as well as academic institutions.
Ralington Pharma LLP, founded in Gujarat in 2015, India is a manufacturer of pharmaceutical products such as chemicals, natural extracts and pellets. The company's product portfolio includes Active Pharma Ingredients, Specialty Pharmaceuticals, and Generic Pharmaceuticals. The company serves industries such as healthcare, pharmacies, clinical research, and Chemical and Petrochemicals. The company offers customer services that include support, custom research projects and customized services. The company also have microbiological testing services for products and pharmaceutical water, antimicrobial effectiveness tests and method suitability tests.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Biomol GmbH, founded in 1968 and headquartered in Heidelberg, Germany, is a manufacturer, supplier, and distributor of life science products for the biomedical research domain. The company's range of products includes primary antibodies that originate from different host species such as mouse, rabbit or goat, dyes and labeling reagents, qPCR gene family primers, as well as virus-based tools used to manipulate genetic material and study viral infections. These scientific resources find applications across various disciplines, including molecular biology, academic research of drug development, pharmaceutical development of antibodies, and clinical diagnostics of viral infections.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Chemodex Ltd. |
66.7%
|
| 2 | Ralington pharma LLP |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the isopropylantipyrine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
1 | 25.0% |
|
Japan
|
1 | 25.0% |
|
Switzerland
|
1 | 25.0% |
|
Germany
|
1 | 25.0% |
