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This section provides an overview for amitriptyline as well as their applications and principles. Also, please take a look at the list of 7 amitriptyline manufacturers and their company rankings. Here are the top-ranked amitriptyline companies as of December, 2024: 1.Cayman Chemical Company, 2.Teva Pharmaceutical Industries Ltd, 3.Bio-Techne.
Table of Contents
Amitriptyline, also known as Tryptanol, is a member of the tricyclic antidepressant family. It was the first developed antidepressant and is used as a hydrochloride salt in pharmaceuticals and pharmacological research. Amitriptyline affects neurotransmitters in the brain and plays a role in biological phenomena at minute levels.
Primarily used as an antidepressant, amitriptyline relieves anxiety, depressed mood, and lethargy in humans. It improves the function of noradrenaline and serotonin in the brain, facilitating neurotransmission. Additionally, it is used to treat chronic nerve-related pain, migraines, tension-type headaches, and nocturia due to its sedative effects.
Amitriptyline is a white or light brown crystalline powder with a melting point of around 196°C. It is soluble in water, ethanol, acetone, and acetic acid, but insoluble in diethyl ether. It has the chemical formula C20H23N, a molecular weight of 277.403 g/mol, and a bitter and paralyzing taste. As a tricyclic compound, it contains three connected rings, including a benzene ring at each end.
Amitriptyline acts on neuronal receptors involved in neurotransmission, inhibiting the reuptake of noradrenaline and serotonin. Clinical effects usually occur one to two weeks after starting treatment.
It is considered an option for treating neuralgia and is as effective as Pregabalin, Duloxetine, and Gabapentin in the treatment of painful diabetic neuropathy.
Gradual reduction of amitriptyline is required to avoid withdrawal symptoms. Side effects include dry mouth, drowsiness, dizziness, constipation, urinary problems, and a risk of cardiogenic arrhythmias and self-injury. It may also increase the risk of suicidal thoughts and should be used with caution.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Bio-Techne, established in 1970 and headquartered in Minneapolis, USA, is a supplier and manufacturer of essential tools for life science research, therapeutics, and clinical diagnostics. The company offers an extensive product range, including purified proteins and reagent solutions, with a notable emphasis on cytokines and growth factors, along with antibodies, immunoassays, biologically active small molecule compounds, tissue culture reagents, and gene therapy workflow solutions, including T-Cell activation technologies. Furthermore, it provides protein analysis solutions, streamlining researchers' workflows for automated Western blot and multiplexed ELISA techniques.
Vasudha Pharma Chem Limited, founded in 1994 and headquartered in Telangana, India, is a manufacturer of active pharmaceutical ingredients (APIs) for domestic and international markets. The product line of the company includes pellets, under-development APIs, piperidone and piperidine derivatives, intermediates, and APIs utilized in the chemical and pharmaceutical industries. It has five manufacturing sites spread out over India with regulatory licenses from the USFDA, KFDA, Mexican MOH, and cGMP. In 2021 and 2022, the company got certifications for ISO 14001:2015, WHO GMP, ISO 45001:2018, and CEP.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
TCI America is based in Portland, Oregon, USA, and is a manufacturer and distributor of organic chemicals that was incorporated as the U.S. subsidiary of Tokyo Chemical Industry Co. Ltd. in 1985. The company specializes in producing organic chemicals used for research and development purposes. These include polymer additives, organic synthesis reagents, and chromatography columns. The company also offers contract research, bulk production, and custom synthesis services for clients in research institutions, or for production facilities with unique project specifications.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Cayman Chemical Company |
29.9%
|
| 2 | Teva Pharmaceutical Industries Ltd |
27.2%
|
| 3 | Bio-Techne |
19.0%
|
| 4 | TCI America |
8.2%
|
| 5 | MilliporeSigma |
6.1%
|
| 6 | Vasudha Pharma Chem Limited |
5.4%
|
| 7 | Dipharma Francis Srl |
4.1%
|
Derivation Method
The ranking is calculated based on the click share within the amitriptyline page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 66.7% |
|
India
|
1 | 33.3% |
