Biomolecular interaction analysis device Monolith series-NMO-GO31

Biomolecular interaction analysis device Monolith series
Central Scientific Trading Co., Ltd.

About This Product

■SummaryNanoTemper's two unique technologies (microscale thermophoresis and Spectral Shift) accurately and quickly capture the interaction between two molecules and provide it as Kd. Since it does not have a flow path, regular maintenance is not required, and Kd can be determined with a very simple operation. Monolith is a standard type that measures with a capillary, and Dianthus is a high-throughput type that measures with a plate.

■Microscale thermophoresisHeat is applied to a sample in a solution, and changes in fluorescence intensity due to thermal equilibrium movement of the target molecule and changes in the fluorescence intensity of the molecules themselves are captured, and changes in fluorescence intensity over time are measured. The degree of this change in fluorescence intensity changes depending on whether the ligand is bound or not. Measure the change in fluorescence intensity for each ligand concentration, draw a sigmoid curve based on the difference in the changes in fluorescence intensity, and calculate Kd.

■Spectral ShiftWhen a ligand binds to a target, the fluorescence spectrum changes. In this measurement technique, the target is labeled with a fluorescent label, a fixed amount is mixed with a series of dilutions of the ligand, excited at 590 nm, and the binding state is detected as a shift in the fluorescence spectrum.

To detect this movement, fluorescence is detected at two wavelengths, 650 nm and 670 nm, and KD is calculated by plotting the ratio of the fluorescence intensities on the vertical axis and the ligand concentration on the horizontal axis. Since ratios are used in the KD calculation process, the calculation formula is (1). Therefore, noise can be canceled out by calculation, improving the S/N ratio. This makes it possible to detect even subtle shifts with great precision.

■Quick measurement・Monolith One Kd measurement time is about 10 minutes (24 capillary measurements)
・Measurement time for Dianthus 1 plate (384 wells) is improved by about 30 minutes.

■Molecular weight of binding targetMeasures Kd from pM to mM for all molecular weights from ions to ribosomes

■No immobilization required, no high purity purification required (when using His-tag labeling)- Can be analyzed in any buffer and bioliquid (cell lysate, serum)
・Measurement without immobilization
・Various options such as labeling and measurement, label-free measurement, etc.

■Improve research efficiency・Easy operation that even beginners can understand
・No regular maintenance required as there is no flow path

Model
There is 1 model available for this product.

Product
Biomolecular interaction analysis device Monolith series

Handling Company
Central Scientific Trading Co., Ltd.

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Spectroscopic Analyzer

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1 Models of Biomolecular interaction analysis device Monolith series

Image	Part Number	Price (excluding tax)	Product name/code	Detector Nano Blue	Detector Nano red
	NMO-GO31	Available upon quote	MO24NB/NR	○	○

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Central Scientific Trading Co., Ltd.

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Biomolecular interaction analysis device Monolith series Central Scientific Trading Co., Ltd.

About This Product

■Summary

■Microscale thermophoresis

■Spectral Shift

■Quick measurement

■Molecular weight of binding target

■No immobilization required, no high purity purification required (when using His-tag labeling)

■Improve research efficiency

1 Models of Biomolecular interaction analysis device Monolith series

NMO-GO31

Customers who viewed this product also viewed

Other products of Central Scientific Trading Co., Ltd.

About Company Handling This Product

Related search keywords

Biomolecular interaction analysis device Monolith series
Central Scientific Trading Co., Ltd.