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This section provides an overview for choline chloride as well as their applications and principles. Also, please take a look at the list of 14 choline chloride manufacturers and their company rankings. Here are the top-ranked choline chloride companies as of December, 2024: 1.Junsei Chemical Co.,Ltd., 2.KANTO CHEMICAL CO.,INC., 3.Ennore India Chemicals.
Table of Contents
Choline chloride is an organic compound classified as a quaternary ammonium salt with the chemical formula C5H14ClNO. It has a pivotal role in the body, either as a component of phospholipids or as the neurotransmitter acetylcholine, similar to its derivative, phosphatidylcholine.
While the body can synthesize choline, inadequate protein intake may lead to insufficient production, potentially resulting in a fatty liver.
Choline chloride is widely used in health food supplements and animal feeds, particularly in the poultry industry, reflecting its growing market. It is essential for maintaining cell membrane integrity, acting as a neurotransmitter via its conversion to acetylcholine, and serving as a methyl group donor through its metabolite, trimethylglycine (betaine), in the metabolic pathway for synthesizing S-adenosylmethionine.
This compound appears as a white crystal or crystalline mass with a characteristic odor, identified by CAS No. 67-48-1. It melts at 305°C and is highly soluble in water and ethanol, with sensitivity to light and hygroscopic properties. When handling, precautions are necessary due to the potential release of hazardous decomposition products like carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen chloride gas.
While not classified under GHS, handling choline chloride requires caution and appropriate protective gear. Instructions cover procedures for inhalation, skin or eye contact, and ingestion, emphasizing immediate medical attention or thorough washing as needed.
Protective measures include using dust-proof respirators, gloves, and safety glasses. Workplaces should implement local exhaust ventilation and provide emergency wash stations.
Choline chloride should be stored in airtight glass containers in cool, well-ventilated areas, away from light and strong oxidizers, to prevent moisture absorption. Compliance with disposal regulations is also advised.
In the event of a fire, various extinguishing media such as water spray, carbon dioxide, foam, or sand may be used, taking care to wear protective equipment due to the risk of toxic gases.
The choline chloride market is projected to expand at a CAGR of 4.11% from 2021 to 2026, driven by demand from the livestock industry and its benefits as a human supplement for liver health, brain development, muscle metabolism, and nervous system function.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Ennore India Chemicals, established in 1995, and based in Tamil Nadu, India, is a manufacturer and supplier of industrial chemicals and cleaning solutions. The company serves various industries, including wastewater treatment, marine, power generation, and oil and gas. Ennore India Chemicals also provides fuel additives, corrosion inhibitors, descaling chemicals, chemicals for boiler water treatment, as well as chemicals for cooling towers. Their ISO 9001:2015 certification guarantees quality goods and environmentally friendly practices.
SDA Products, founded in Mumbai, Maharashtra, in 1997 is a manufacturer and supplier of Veterinary Products. The company's product portfolio includes Bentonite Powder, Copper Sulphate Powder, Dextrose Monohydrate Powder, Ferrous Sulphate Crystals and Ferrous Sulphate Powder. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company has a global distribution network, a customer support center, R&D center and quality control services.
Jinan Pengbo Biotechnology Co., Ltd. is a manufacturer and supplier specializing in biotechnology products. Headquartered in Jinan, Shandong, China, the company was in 2013. Jinan Pengbo Biotechnology specializes in producing a diverse array of biotechnology products such as betaine anhydrous, betaine hydrochloride, DMAE bitartrate, urea, and calcium pyruvate, while pivoting on choline and betaine derivatives. These products find applications in various sectors, including animal nutrition, pharmaceuticals, and personal care. The company provides comprehensive services, including custom synthesis, technical support, and tailored solutions to address the unique needs of its clients.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
MainChem Co., Ltd, established in 2014, is a Chinese manufacturer and distributor of fine and specialty chemicals, with its headquarters located in Xiamen, Fujian. The company's product portfolio includes life science chemicals, petrochemicals, and specialty chemicals. Some of MainChem’s chemical substances have passed evaluations based on Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), a European Union regulation. These chemicals are used in various industries, including cosmetics, food additives, personal care product, and water treatment. MainChem offers the "ONE-STOP" solution for chemical sourcing from China. They also provide custom chemical synthesis services, encompassing the entire process from initial research to commercial-scale production.
Eastman Chemical was founded in 1920 and is headquartered in Kingsport, Tennessee. The company is a manufacturer and distributor of specialty chemicals, including coatings, adhesives, fibers, and plastics for industries such as automotive, medical, manufacturing, and construction. The company operates through four segments: Additives & Functional Products, Advanced Materials, Chemical Intermediates, and Fibers segments. Additives & Functional Products include food and fertilizer-based products. Advanced Materials include films and other chemicals used in transportation and electronics. Chemicals include phthalate plasticizers and other plastic products. Fibers include cigarette filters and other products.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Celtic Chemicals, Ltd. was established in 1979 and headquartered in Port Talbot, United Kingdom. The company is a producer and trader of many chemical compounds including inorganic metallic salts, biogas, nutritional chemicals, pharmaceutical, and metal finishing for biotech, semiconductor, nutrition, and numerous other industries in laboratories achieved and maintained the standards of ISO 9001-2015 since 1993. Chemical compounds offered by the company are offered in both large quantities and quantities as small as 1 kilogram. For chemicals such as Zinc that require high purity, the company pre-blends micro elements to ensure consistent dispersion across entire batches.
Kavya Pharma, established in 2009 in Surat, Indian state of Gujarat, is a pharmaceutical manufacturing company that specializes in the production and supply of WHO-GMP certified pharmaceutical products, including Active Pharmaceutical Ingredients (API) and Intermediates. The company offers a range of pharmaceutical medicines, including ichthammol, gentamicin sulfate, neomycin sulfate, and polymyxin b sulfate. In addition to these products, they also manufacture, export, and supply specialty chemicals, pharmaceutical raw materials, API & other bio fertilizer products, poly aluminum chloride, and psyllium herb.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Junsei Chemical Co.,Ltd. |
14.5%
|
| 2 | Ennore India Chemicals |
13.4%
|
| 3 | KANTO CHEMICAL CO.,INC. |
13.0%
|
| 4 | Eastman Chemical Co. |
8.8%
|
| 5 | SDA Products |
8.0%
|
| 6 | Celtic Chemicals Ltd |
8.0%
|
| 7 | Jinan Pengbo Biotechnology Co., Ltd. |
6.9%
|
| 8 | RAINBOW HEALTH CARE PRODUCTS |
6.5%
|
| 9 | Foodchem International Corporation |
4.2%
|
| 10 | Kavya Pharma |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the choline chloride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 50.0% |
|
Japan
|
3 | 25.0% |
|
China
|
2 | 16.7% |
|
United Kingdom
|
1 | 8.3% |
