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This section provides an overview for amyl nitrite as well as their applications and principles. Also, please take a look at the list of 10 amyl nitrite manufacturers and their company rankings. Here are the top-ranked amyl nitrite companies as of December, 2024: 1.THE BioTek., 2.Spectrum Chemical Mfg. Corp., 3.Dr. Zia Pharmaceuticals.
Table of Contents
Amyl nitrite is an organic compound, an ester of nitrite, with the molecular formula C5H11NO2. While amyl nitrite typically refers to a group of isomeric nitrite esters, this section focuses on both n-amyl nitrite and isoamyl nitrite, each having a molecular weight of 117.15.
n-Amyl nitrite, or Pentyl Nitrite, is a clear yellowish liquid at room temperature, with a boiling point of 104-105 °C. It has a sweet smell and a density of 0.836 g/mL. This compound decomposes upon contact with water, is practically insoluble (solubility 3.97 g/L), but is miscible with organic solvents like ethanol, ether, and chloroform. Its CAS registration number is 463-04-7.
Isoamyl nitrite, also known as Isopentyl nitrite, is a clear yellowish liquid with a fruity odor and a density of 0.875 g/mL. It boils at 99 °C and is practically insoluble in water, but miscible with chloroform, ethanol, and ether. The flash point of isoamyl nitrite is 3 °C.
Isoamyl nitrite is used in cardiac medications for conditions like angina pectoris and as an antidote for cyanide poisoning. It is also used as an inhalant due to its vaporizing tendency and sometimes as an antidote for hydrogen sulfide poisoning. A small amount can be absorbed onto a piece of cloth and inhaled to alleviate seizures immediately.
The principles of amyl nitrite are rooted in its chemical properties. Amyl nitrite is synthesized through the esterification of amyl alcohol with nitric acid. It's used in organic chemistry for diazotization of primary amines and N-nitrosation of secondary amines. A typical application is in the Sandmeyer reaction, involving halogen substitution in aromatic rings.
Isoamyl nitrite works in cyanide detoxification by oxidizing the Fe2+ in hemoglobin to Fe3+ methemoglobin. This inhibits the binding of cyanide to cytochrome oxidase. Additionally, when administered with sodium thiosulfate, it helps convert cyanogen to thiocyanate, aiding detoxification.
Both n-amyl nitrite and isoamyl nitrite are sold under the name amyl nitrite. However, they can be distinguished in chemical reagents by their aliases or CAS registry numbers. Drugs labeled as amyl nitrite predominantly contain isoamyl nitrite.
*Including some distributors, etc.
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THE BioTek is a manufacturer of monoclonal and polyclonal antibody that was established in 1989 and is headquartered in the City of Industry, California, USA. The company produces, per customization, a wide range of products, including chemical compounds, bioactive reagents, catalysts and ligands, materials science and inhibitors/agonists. Its products are used by a number of industries, as diverse as biotechnology, pharmaceutical, diagnostics, and academic research. THE BioTek also provides a range of services to its customers, including protein crystallization, antibody production and recombinant protein expression.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Dr. Zia Pharmaceuticals, which was formed in 1951 and is based in Karachi, Pakistan, is a manufacturer of natural homoeopathic, herbal, and nutraceutical products. The company fabricates sugar-free tonics, pain relief oils, remedies, and silver fir bud extracts. It also makes bio-mineral salts, nourishing oils, as well as lotions. One of the variants of its sugar-free tonics, Alfalfa Z, helps relieve symptoms associated with general weakness, lack of appetite, anemia, and eating disorders.
Similia Homoeo Laboratory which was founded in 1986 and is located in Aluva, India, is a manufacturer of homoeopathic medicines. The company makes Arsenic IOD, Bryonia medicated pills, Grindelia Rob medicated pills, and Lobelia Inflata medicated pills. It also manufactures Phytolacca D medicated pills, Pulsatilla medicated pills, Pyrogen medicated pills, and Sarsaprilla medicated pills. Arsenic IOD is a homoeopathic remedy that helps in lowering the temperature, relieving abdominal typhus, and is excellent in eliminating sweating, as well as improving the overall immune system.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc. is a Japanese biotechnology company that specializes in the production and distribution of research reagents and diagnostic kits. Founded in 1958, Nacalai Tesque has grown into a globally recognized brand, serving customers in over 100 countries. The company's product portfolio includes antibodies, biochemicals, cell culture reagents, and more. Nacalai Tesque also offers contract research services for drug discovery and development. With a team of experienced professionals and state-of-the-art facilities, the company is committed to providing its customers with reliable and innovative solutions to their research needs.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | THE BioTek. |
33.9%
|
| 2 | Spectrum Chemical Mfg. Corp. |
15.2%
|
| 3 | Dr. Zia Pharmaceuticals |
9.4%
|
| 4 | Santa Cruz Biotechnology, Inc. |
8.2%
|
| 5 | Similia Homoeo Laboratory. |
7.6%
|
| 6 | Toronto Research Chemicals |
6.4%
|
| 7 | Tokyo Chemical Industry Co., Ltd. |
5.8%
|
| 8 | Merck |
5.3%
|
| 9 | Nacalai Tesque Inc. |
4.1%
|
| 10 | Otto Chemie Pvt. Ltd |
4.1%
|
Derivation Method
The ranking is calculated based on the click share within the amyl nitrite page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 33.3% |
|
India
|
2 | 22.2% |
|
Japan
|
2 | 22.2% |
| Pakistan | 1 | 11.1% |
|
Canada
|
1 | 11.1% |
