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This section provides an overview for malondialdehyde as well as their applications and principles. Also, please take a look at the list of 11 malondialdehyde manufacturers and their company rankings. Here are the top-ranked malondialdehyde companies as of December, 2024: 1.Northwest Life Science Specialties, LCC, 2.Cell Biolabs, Inc..
Table of Contents
Malondialdehyde (MDA) is a dialdehyde with the formula C3H4O2. It is a highly reactive molecule, rarely found in its pure form. Commercially, it is obtained through the hydrolysis of 1,1,3,3-tetramethoxypropane.
As a byproduct of lipid peroxidation, malondialdehyde serves as a biological marker for oxidative stress, indicating cell membrane damage and the presence of lipid peroxides in the body. It is particularly useful in assessing sperm membrane integrity, offering insights into fertility-related issues.
Malondialdehyde melts at 72°C and boils at 108°C. It forms adducts with 2-thiobarbituric acid reactive substances, exhibiting strong absorption near 532 nm, which facilitates its spectroscopic detection. Elevated MDA levels have been documented in various medical conditions, including corneal and joint diseases.
The structural formula for malondialdehyde is CH2(CHO)2, highlighting its dual aldehyde groups. It predominantly exists in the enol form, with its isomerization influenced by the solvent's nature. This dynamic equilibrium affects the cis and trans forms' distribution in different solvents.
Malondialdehyde is produced through the oxidation of polyunsaturated fatty acids by free radicals, leading to a series of reactions that ultimately yield MDA. This process also occurs in heated edible oils, contributing to nutritional and health considerations.
As an indicator of lipid peroxidation, malondialdehyde's measurement is pivotal in studying oxidative stress and cell death mechanisms like ferroptosis. It reacts with cellular biomolecules, causing DNA and protein damage, making it a significant target in disease research, including investigations into diabetes and cancer.
*Including some distributors, etc.
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Cell Biolabs, Inc. was established in 2004 and is headquartered in San Diego, California, United States, and is a manufacturer of instruments and tools for life science research applications. The company's product folio includes Cell-Based Assays, Viral Expression and Purification Kits, Reagents, Oxidative Stress Assays, and, Metabolism Research Assays and Reagents for research laboratories of universities, government institutes, biotechnology and pharmaceutical companies. The company specializes in Cell Signaling and Protein Biology as well as provides products that facilitate the discovery of the mechanisms underlying cell function and disease.
BioVision Inc., established in 1999 and based in Waltham, Massachusetts, is a manufacturer and supplier of life science research products. The company is a part of the Abcam company. The company provides various biochemicals, assay kits, and research reagents. These products are used in research fields such as autophagy, cell damage and oxidative stress, food science, signal transduction, and drug metabolism and disposition. Its products are essential tools for scientists and researchers worldwide, aiding in advancing medical and biological sciences. The company adheres to ISO 13485 standards, ensuring its quality management systems in producing research products for life sciences.
Enzo Life Sciences, Inc., established in 1976 and headquartered in Farmingdale, New York, is a manufacturer and provider of life sciences and diagnostic products. The company specializes in producing a diverse range of research reagents, assays, and diagnostic kits used in various fields, including genomics, immunology, and oncology. The company’s products are utilized in advancing scientific research and clinical diagnostics. The company is partnered with ALEXIS Biochemicals, Assay Designs, Stressgen, and Axxora.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
StressMarq Biosciences Inc. is a manufacturer of research products for the life sciences and drug discovery and biopharma market bioreagents. The company is based in Victoria, British Columbia, Canada and was established in 2007. Its main activities include developing and commercialising a range of unique fibrilized and oligomeric protein preparations for use in neurodegenerative disease research. The company's main products include antibodies, proteins, kits, and small molecules as well as antibodies against alpha-synuclein, tau, and amyloid beta. StressMarq offers services such as training, and custom protein synthesis. Its products are used in many industries, including neuroscience, cancer research, and cell signalling.
Aurum Pharmatech LLC, founded in 2002 and headquartered in Frisco, Texas, is a global supplier of fine chemicals, pharmaceutical intermediates, and research chemicals. The company’s core business is providing chemical building blocks, which include functionalized heterocycles, boronic acids, carbonyl compounds, alkynes, azides, and halogenated compounds. The company serves various industries, including pharmaceuticals, biotechnology, and academia. Its products are used in the advancement of drug discovery and development. The company is partnered with shipping companies like FedEx, UPS, and DHL.
Ethos Biosciences, founded in the United States in 1988, is a supplier of diabetes-related diagnostic products. The company offers blood glucose monitoring systems that are accurate, easy to use, and designed to help individuals keep their glucose levels in check and range of insulin delivery solutions includes insulin pumps and pens. It is a family owned and operated group of specialty chemical manufacturing companies with expertise in monomers, polymers, microspheres, and reagents for the pharmaceutical, medical device, and diagnostic industries.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Merck |
50.0%
|
| 2 | Northwest Life Science Specialties, LCC |
25.0%
|
| 3 | Cell Biolabs, Inc. |
25.0%
|
Derivation Method
The ranking is calculated based on the click share within the malondialdehyde page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 66.7% |
|
Italy
|
1 | 16.7% |
China
|
1 | 16.7% |
