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This section provides an overview for phosphinic acids as well as their applications and principles. Also, please take a look at the list of 8 phosphinic acid manufacturers and their company rankings. Here are the top-ranked phosphinic acid companies as of December, 2024: 1.Hairui Chemical, 2.KANTO CHEMICAL CO.,INC., 3.nacalai.
Table of Contents
Phosphinic acid is a phosphorus oxyacid with oxidation number I.
Its IUPAC formal name is dihydridodioxophosphoric acid, and its disproportionation reaction occurs above 130 °C to form phosphoric acid (H3PO4) and phosphine (PH3).
It has strong reducing properties and can reduce Cu2+ and Ag+. It is deliquescent and soluble in water, alcohols, and ethers. Its pKa is 1.244 at 25 °C.
Phosphinic acid is widely used as a catalyst and reducing agent in organic synthesis, surface treatment agents for metals and other materials, antioxidants, thermal alteration inhibitors, and plating materials. It is also used as raw material for phosphinic acid salts.
Phosphinic acid is used as a reducing agent in electroless nickel plating on steel and plastics. In this process, phosphinic acid salts are oxidized to phosphites, releasing electrons to reduce nickel ions to nickel.
Phosphinic acid has a melting point of 26.5 °C. It decomposes at temperatures above 100 °C, forming phosphine (PH3), phosphonic acid (H3PO3), and eventually phosphoric acid (H3PO4).
Figure 1. Tautomers of phosphinic acid
Phosphinic acid, with the chemical formula H3PO2, is an inorganic phosphorus compound featuring a P-H bond and a phosphoryl group (P=O). It has a formula weight of 66.0, a specific gravity of 1.45, and a specific formula of (HO)PH2(=O).
The presence of the PH2 group in phosphinic acid has been confirmed by physical measurements such as nuclear magnetic resonance (NMR). It is tautomeric with hypophosphinic acid, which has the same chemical formula.
Figure 2. Synthesis of phosphinic acid
To synthesize phosphinic acid industrially, white phosphorus is first treated with slaked lime to produce a calcium salt. This calcium salt is then converted to a sodium salt, resulting in sodium phosphinic acid. Finally, sodium phosphinic acid is converted to phosphinic acid using an ion exchange resin. Alternatively, phosphinic acid can be prepared by oxidizing phosphine oxide with hydrogen peroxide or iodine.
Figure 3. Structure of a derivative of phosphinic acid
Organic derivatives of phosphinic acid include alkyl phosphinic acids. These are compounds where one or two H atoms of the PH2 group are replaced by alkyl group R, forming monoalkyl phosphinic acid (RHP(O)OH) or dialkyl phosphinic acid (R2P(O)OH), respectively. There are also alkyl esters of phosphinic acid, where the H atom of the OH group is replaced by an alkyl group, known as phosphinic acid esters.
Phosphinic acid is one of several phosphorous oxoacids. Other such oxoacids include phosphoric acid (H3PO4), phosphorous acid (H3PO3), phosphonic acid (H2PHO3), and peroxomonophosphoric acid (H3PO5), with phosphorus oxidation numbers of +5, +3, +3, and +5, respectively.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
TLC Pharmaceutical Standards Ltd. is a manufacturer and supplier of reference standards for the pharmaceutical sector. It is headquartered in Mississauga, Ontario, Canada, and was established in 2006. The company specializes in the custom synthesis of complex organic compounds for use as reference standards by the bio-medical and pharmaceutical industries. It offers a wide range of reference standards, including active pharmaceutical ingredients (APIs), drug impurities, and metabolite standards. TLC Pharmaceutical Standards also offers services, such as custom synthesis and Analytical Services such as NMR Analysis and Mass Spectrometry Analysis. The company's customers include pharmaceutical companies, research institutions, and government agencies.
Hairui Chemical, founded in China, is a manufacturer of organic compounds. The company's product portfolio includes fluorine compounds, boric acid series, amino acid series, non-natural amino acid series, and organic catalyst series. Its products are used for pharmaceutical ingredients (APIs), various chemical and petrochemical processes, and biotechnological research and product development. The company has ISO 9001: 2015 quality system certification and exports its products to the United States, Europe, and Japan.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
ChemSrc, established in 2014, is a supplier of pharmaceutical products, a chemical database platform, and a search engine. This platform serves as a gateway to an extensive repository of chemical knowledge, offering access to unique CAS-encoded product records including synthesis routes, literature references, physical and chemical properties, and supplier information. The chemical catalog spans various categories, including organic raw materials, dyes and pigments, chemical pesticides, catalysts, additives, and more. The repository information plays a vital role in supporting research and development efforts across diverse industries by fostering scientific advancements and serving as a valuable resource.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Hairui Chemical |
22.7%
|
| 2 | KANTO CHEMICAL CO.,INC. |
22.7%
|
| 3 | nacalai |
18.2%
|
| 4 | ChemSrc |
13.6%
|
| 5 | Toronto Research Chemicals |
13.6%
|
| 6 | TLC Pharmaceutical Standards Ltd. |
4.5%
|
| 7 | MilliporeSigma |
4.5%
|
Derivation Method
The ranking is calculated based on the click share within the phosphinic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 40.0% |
|
Canada
|
2 | 40.0% |
|
China
|
1 | 20.0% |
