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This section provides an overview for hydroxyproline as well as their applications and principles. Also, please take a look at the list of 38 hydroxyproline manufacturers and their company rankings. Here are the top-ranked hydroxyproline companies as of December, 2024: 1.LobaChemie Pct.Ltd., 2.KYOWA HAKKO BIO CO.,LTD., 3.ChemScence.
Table of Contents
Hydroxyproline, abbreviated as Hyp, is a secondary cyclic amino acid derived from the hydroxylation of proline in the presence of vitamin C. Recognized as a key component of collagen, hydroxyproline exists as white, hexagonal crystals, readily soluble in water and marginally in ethanol.
Due to its role in collagen synthesis and skin cell proliferation, hydroxyproline is valued in cosmetics for enhancing skin elasticity, firmness, and moisture, thus counteracting aging signs. However, its topical application is preferred as oral ingestion does not directly benefit skin collagen.
As a collagen marker, hydroxyproline aids in diagnosing conditions related to collagen degradation, including bone diseases, liver fibrosis, and cancer metastases through collagen content measurement in various tissues.
Found abundantly in gelatin and meats, hydroxyproline supplements aim to support dietary needs, particularly for skin, tendon, and bone health.
With the formula C5H9NO3 and a molecular weight of 131.13, hydroxyproline is a white powder that dissolves in water but not in ethanol or ether. It's chemically stable, yet sensitive to high temperatures and direct sunlight.
Lacking specific GHS hazard classifications, hydroxyproline is generally considered safe with recommended storage in cool, well-ventilated areas away from oxidizers and sunlight.
Precautions include using dust-proof masks and protective gear, establishing local exhaust and emergency wash facilities, and maintaining hygiene post-handling.
Hydroxyproline, synthesized via proline hydroxylation, is crucial for collagen's triple helix stability, relying on vitamin C for its formation. A deficiency in vitamin C can compromise collagen stability, leading to scurvy.
*Including some distributors, etc.
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ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
AccuStandard, established in 1986 and headquartered in New Haven, Connecticut, USA, is a manufacturer of Certified Reference Materials (CRMs). The offered products include organic standards, inorganic standards, custom standards, proficiency testing materials, and calibration kits. These products are used to ensure the accuracy, precision, and reliability of analytical methods and instruments in various industries such as environmental, pharmaceutical, food, petrochemical, and forensic. Its products meet stated specifications and comply with international standards, including ISO 17034:2016, ISO/IEC 17025:2017, and ISO 9001:2015.
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
J&K Scientific LLC, located in California, USA, has been a manufacturer and distributor of chemicals, reagents, and laboratory equipment since 1992. The company offers a comprehensive catalog of chemicals and reagents, including organic and inorganic chemicals, biochemicals, solvents, and specialty reagents. These products are essential for laboratory research, manufacturing processes, and analytical applications. The company also provides analytical instruments, balances, centrifuges, and various lab accessories. Its wide range of industries and sectors includes pharmaceuticals, chemical research, environmental analysis, and materials science.
City Chemical LLC. was founded in 1997 and is a manufacturer and supplier of chemical products based in West Haven, Connecticut, United States. The company's product portofolio includes ammonium fluoride, silicon acetate, potassium manganate, silicon bromide, and barium cyanide. The products are used in various industries such as military, aerospace, semiconductor, and research and development. The MOCVD, CVD, and ALD products lineup are used in the semiconductor sectors for producing micro and nano electronics thin films.
ALB Technology Limited, headquartered in Nevada, USA, is a manufacturer, supplier and distributor of reference standards, health ingredients, antibody drug conjugates, and special chemicals. Its product categories include reference standards with verified purity and structure, antibody drug conjugates, chemical reagents, sodium hyaluronate, and special chemicals, serving various industries like pharmaceutical, agrochemical, food, and feed additives. The compaany plays a significant role in providing essential materials for research and engineering applications globally.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Aceschem Inc., headquartered in Dallas, Texas, USA, is a supplier of chemical compounds, operating with research and manufacturing facilities in China. The company produces advanced pharmaceutical intermediates and fine chemicals across various quantities. Its product range includes fluorinated building blocks for pharmaceutical and agrochemical synthesis, intermediates used in compound production, research chemicals for scientific investigations, pharmaceutical intermediates as fundamental components in drug manufacturing, and fine chemicals tailored to specific requirements. It emphasizes intellectual property protection and collaboration with international biotech and pharmaceutical firms.
P212121, LLC, established in 2009 and based in Ann Arbour, Michigan, USA, is a distributor of research chemicals and supplies. The MSDS and Certificate of Analysis are usually listed with the product. A number of companies, nonprofits, and academic institutions in the world rely on the company products every day to keep their labs operating productively. The company offers more than 16,000 products and the ability to make custom glassware. The company provides lab supplies like crystal manipulation, crystal mounts, dewars, and glassware.
Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
CPAChem Ltd, founded in 2001 and based in Bogomilovo, Bulgaria, is a manufacturer of organic and inorganic custom-made certified reference materials as well as pharmacopoeia products and Analytical CRMs. With the capability to produce more than 200 different products daily, it stands as the sole global producer offering products in accordance with seven different pharmacopoeias, including the Japanese, Indian, and British pharmacopoeias. The company boasts a catalog of over 9,000 stock products, serving clients such as Carlo Erba, Fisher, and VWR. It holds ISO 9001 certification and has achieved accreditation in ISO/IEC 17025 and ISO 17034.
Chemodex Ltd., established in 2001 and based in St. Gallen, Switzerland, is a manufacturer of fine chemicals, covering different fields such as reagents for life sciences, bioactive molecules, and organic pollutants. The company offers a range of products including fluorescent substances derived from fluorophores such as coumarin, rhodamine, and pyrene. These products are typically used as probes, stains, and in other applications by life-science researchers in academia, biotechnology, and the pharmaceutical industry. Its customer base includes small and medium businesses, large enterprises, as well as academic institutions.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Henan Tianfu Chemical Co., Ltd., founded in 2009, is a Chinese chemical manufacturer and supplier based in Zhengzhou, Henan. The company has developed over 500 compounds, mostly for fine applications in manufacturing and life science. Their product range includes electronic chemicals, ultraviolet (UV)-curing materials, ionic liquids, and pharmaceutical materials. Additionally, Henan Tianfu has expanded into the fine chemical market, offering noble metal catalysts, organic phosphine ligands, and organic light-emitting diode (OLED) intermediates. They are also involved in the development of pesticides and medical intermediates, as well as the analysis and synthesis of electronic chemical materials.
Ebrator Biochemicals, Inc. is a manufacturer and supplier of fine chemicals and life science materials for use in the pharmaceuticals, biotech, and healthcare industries. Founded in 2018 and based in Santa Ana, California, the company provides various biological stains and dyes, analytical agents, impurities, and DNA cloning materials for applications in diagnostics and scientific research. The company’s specialized product range includes amino acids and carbohydrates, ACS reagents, plasmids and restriction enzymes. Ebrator Biochemicals, Inc. also offers custom synthesis and packaging services for its clients, which include Quest Diagnostic, Pfizer, and Thermo Fisher Scientific.
Shandong Chuangying, established in 2005 and based in China, is a manufacturer of chemicals. The company produces products such as disinfectant and antiseptic series, daily chemicals, cosmetic raw materials, food/feed additives, and catalysts & chemical auxiliary agents and supplies to different industries such as agriculture, cosmetics, industrial, pharmaceutical, and chemical. All these products are exported to different countries such as Asia, Southeast Asia, Europe, and America. The product line is produced according to the ISO9001, ISO14001, and GB/T-28001 requirements, and the company holds ISO-9001, CE, and SGS certifications.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Biomol GmbH, founded in 1968 and headquartered in Heidelberg, Germany, is a manufacturer, supplier, and distributor of life science products for the biomedical research domain. The company's range of products includes primary antibodies that originate from different host species such as mouse, rabbit or goat, dyes and labeling reagents, qPCR gene family primers, as well as virus-based tools used to manipulate genetic material and study viral infections. These scientific resources find applications across various disciplines, including molecular biology, academic research of drug development, pharmaceutical development of antibodies, and clinical diagnostics of viral infections.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Hefei TNJ Chemical Industry Co., Ltd., founded in 2001, is a chemical manufacturer and supplier in Hefei, Anhui, China. The company has a diverse product portfolio comprising over 60 key products spanning the Chemicals, Food, Pharmaceutical, and Personal Care sectors. Notable products include sophthalic acid, polylysine, as well as chlorin, and potassium acetate. To ensure product quality, the company maintains a robust quality management system that aligns with ISO 9001:2015 standards.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Xiamen Aeco Chemical Industrial Co., Ltd. was established in 2005 and has grown to become a supplier of chemical products, serving customers in various industries. Xiamen Aeco Chemical Industrial Co., Ltd. is a company based in Xiamen, China. The company specializes in the production and distribution of a wide range of chemical products, including pharmaceutical intermediates, agricultural, and other industrial. Their product line includes agrochemicals, APIs, biocides, catalysts, chemical intermediates, cosmetic raw materials, electronic chemicals, food and feed additives, inorganic chemicals, lubricant additives, organic chemicals, paints and coatings, petrochemicals, polymers, solvents, surfactants, textile auxiliary chemicals, water treatment chemicals, and more.
Fisher Scientific UK Ltd is a supplier of laboratory chemicals, equipment, and services based in Loughborough, United Kingdom, operating as a subsidiary of Thermo Fisher Scientific, a merger of Fisher Scientific International, Inc. and Thermo Electron in 2006. With a portfolio of over 2 million products, Fisher Scientific offers chemicals, reagents, equipment and instruments, consumables, and safety products. These products cater to various sectors, including clinical diagnostic and research laboratories, pharmaceutical and biotech industries, healthcare, and government agencies. Fisher Scientific also provides business solutions like the New-Lab Start-Up program, as well as SureTRACE and SureTRACE+ for product knowledge and supply chain management.
Echemi Digital Technology Co. Ltd., started in 2015 and based in Hong Kong, China, is a supplier of chemical raw materials through its B2B digital commerce platform. The company sells products such as propylene carbonate, adipic acid, and oseltamivir phosphate and serves over 100,000 buyers and over 20,000 suppliers in more than 190 countries worldwide. It also provides price and market analysis of over 500 raw materials per week in the areas of coatings, fine chemicals, and pharmaceuticals. It also covers food and nutrition and was ranked 55th in the 2022 ICIS top 100 chemical distributors.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | LobaChemie Pct.Ltd. |
41.7%
|
| 2 | KYOWA HAKKO BIO CO.,LTD. |
33.3%
|
| 3 | ChemScence |
8.3%
|
| 4 | LGC Standards |
8.3%
|
| 5 | Spectrum Chemical Mfg. Corp. |
8.3%
|
Derivation Method
The ranking is calculated based on the click share within the hydroxyproline page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
12 | 38.7% |
|
China
|
4 | 12.9% |
|
Japan
|
3 | 9.7% |
|
United Kingdom
|
3 | 9.7% |
|
India
|
2 | 6.5% |
|
Switzerland
|
2 | 6.5% |
|
Germany
|
2 | 6.5% |
|
Bulgaria
|
1 | 3.2% |
| United States | 1 | 3.2% |
|
Canada
|
1 | 3.2% |
