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This section provides an overview for thiamazole as well as their applications and principles. Also, please take a look at the list of 8 thiamazole manufacturers and their company rankings. Here are the top-ranked thiamazole companies as of December, 2024: 1.Alsachim, 2.Pfizer, 3.SimSon Pharma Limited.
Table of Contents
Thiamazole is an organic compound that is a nitrogen-containing heterocyclic compound.
Its chemical formula is C4H6N2S. It has a five-membered ring molecular structure of thiourea in the molecule and is also a derivative of imidazole. Its other common name is methimazole, which is 1-methyl-3H-imidazole-2-thione, according to IUPAC nomenclature.
It has a molecular weight of 114.17 and a melting point of 294.8°F (146°C). It is a white to light yellowish brown crystalline powder to powdery solid at room temperature. It has a characteristic odor and is easily soluble in water. Its solubility in water is 2.75 mg/mL (at 20°C). It is soluble in chloroform, alcohols, and pyridine, slightly soluble in benzene, and insoluble in ether.
Decomposition produces toxic substances such as carbon dioxide, carbon monoxide, nitrogen oxides (NOx), and sulfur oxides (SOx). Therefore, when storing, it is necessary to avoid high temperatures, direct sunlight, and contact with strong oxidizers. Although there are no specific legal regulations, there is a possibility of allergic skin reactions and a suspicion of adverse effects on fertility or the fetus.
Thiamazole is primarily used in antithyroid medications. It is most commonly used in the treatment of excessive thyroid hormone levels, i.e., in the treatment of hyperthyroidism.
Other uses include lowering blood thyroid hormone levels before therapeutic intervention, to minimize the effects of thyroid manipulation in thyroid surgery or radioactive iodine therapy. Thiamazole, as a drug, is considered to be fast-acting, has few side effects, and is considered a major first-line drug.
Originally developed as a drug for humans, it is now actively used to treat hyperthyroidism in cats. It is a mainstream therapeutic agent, especially in Europe and the United States. As a general organic compound, it is also used in synthetic organic chemistry.
The structure of thiamazole differs depending on its application.
Thiamazole, as an antithyroid drug, inhibits thyroid hormone biosynthesis by blocking thyroid peroxidase, an enzyme in the thyroid gland. Biosynthesis of thyroxine, a type of thyroid hormone, requires iodination of thyroglobulin by thyroid peroxidase.
Thioamide compounds, including thiamazole, are believed to inhibit many steps in thyroid hormone biosynthesis, and one of the reactions inhibited by thiamazole is the iodination of thioglobulin.
One of the serious side effects caused by thiamazole is agranulocytosis. Agranulocytosis is a condition in which the number of white blood cells in the blood, especially neutrophils, drops. If a patient experiences fever or sore throat while taking thiamazole, agranulocytosis should be suspected immediately, and if agranulocytosis develops, thiamazole should be discontinued under medical supervision.
In synthetic organic chemistry, thiamazole is also useful as a scavenger of free radicals, such as hydroxyl radicals (OH).
The types of thiamazole currently available include pharmaceuticals and chemical reagents. As a chemical reagent, thiamazole is sold in volumes of 5 g, 25 g, and 100 g. It is a reagent that can be stored at room temperature. It is used as a raw material for organic synthesis.
Thiamazole, as a pharmaceutical product, is used as an antithyroid drug, as mentioned above. It is marketed under the trade name Mercazole and is available at 2.5 mg and 5 mg. The dosage form is film-coated tablets. It is indicated for hyperthyroidism and requires a prescription from a physician.
*Including some distributors, etc.
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Pfizer Inc., an American multinational pharmaceutical and biotechnology manufacturing corporation, was established in 1849 in New York. The company is a major manufacturer of biopharmaceuticals, offering products to treat different conditions such as cardiovascular, metabolic and pain, women’s health, cancer, immune disorders, and rare diseases. It applies science and global resources to bring therapies to people that extend and significantly improve their lives. Its portfolio includes medicines and vaccines, as well as many of the world’s famous consumer health care products. It works across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Veeprho, established in 2011 and headquartered in Praha, Czech Republic, is a manufacturer of industrial chemicals. It is a chemical research company involved in the research, development, and supply of synthesized impurities, metabolites, intermediates, and active pharmaceutical ingredients (APIs) through custom synthesis. These products are utilized in the global pharmaceutical industry. Its global network is comprised of manufacturing and R&D facilities in India, as well as distribution offices in New Jersey US, and United Kingdom equipped to provide immediate support within all time zones.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alsachim, headquartered in Strasbourg, France, is a supplier of reference standards and stable isotope-labeled compounds for analytical and life science research. Established in 2005, the company produces a wide range of compounds, including pharmaceutical reference standards, metabolites, drug impurities, and environmental contaminants. These products serve industries such as pharmaceuticals, biotechnology, clinical research, and environmental analysis. The company's products find application in analytical method development, pharmacokinetics, and biomarker discovery, enabling advancements in drug development, toxicology, and environmental monitoring.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Alsachim |
50.0%
|
| 2 | Pfizer |
33.3%
|
| 3 | SimSon Pharma Limited |
16.7%
|
Derivation Method
The ranking is calculated based on the click share within the thiamazole page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
2 | 40.0% |
|
United States of America
|
1 | 20.0% |
|
Germany
|
1 | 20.0% |
|
France
|
1 | 20.0% |
