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This section provides an overview for thiazolidine as well as their applications and principles. Also, please take a look at the list of 8 thiazolidine manufacturers and their company rankings. Here are the top-ranked thiazolidine companies as of December, 2024: 1.Matrix Fine Chemicals GmbH.
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Thiazolidine is a heterocyclic compound with the chemical formula C3H7NS, identifiable by its CAS number 504-78-9. It is a clear, colorless liquid at room temperature, with a molecular weight of 89.16, a boiling point of 72~75℃, and a density of 1.131g/cm3. The flash point is 132.8°F (56°C). It's crucial to handle Thiazolidine cautiously, as it produces hazardous decomposition products like carbon oxides, nitrogen oxides (NOx), and sulfur oxides when ignited. Stable under normal storage conditions, it should be kept away from heat, flame, sparks, and strong oxidizers.
While Thiazolidine itself is not commonly used, its derivatives are significant in pharmaceuticals, particularly in β-lactam antibiotics like penicillin and thiazolidinedione (TZD) diabetes drugs. Thiazolidinedione drugs, used in treating type 2 diabetes, improve insulin resistance by binding to PPAR-gamma, a nuclear receptor, and function as transcriptional regulators. These drugs are mainly effective in reducing insulin resistance in peripheral tissues.
Thiazolidine can be synthesized through the hydrolysis of phthalimidoethyl mercaptan or by the condensation reaction of thiols with aldehydes or ketones. This reaction is reversible, leading to the instability of many Thiazolidine derivatives, which easily hydrolyze in water to yield thiols and aldehydes or ketones.
As a chemical reagent, Thiazolidine is sold mainly for research and development in various capacities and can be stored at room temperature.
Thiazolidinedione derivatives, used as diabetes medications, have seen varied market availability. While Troglitazone was withdrawn due to liver damage concerns, Pioglitazone Hydrochloride and Rosiglitazone remain in use, albeit with some restrictions due to potential health risks.
The thiazolidine ring is a crucial component in many β-lactam antibiotics, including penicillin. These antibiotics function by inhibiting bacterial cell wall synthesis, offering both bacteriostatic and bactericidal actions.
*Including some distributors, etc.
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Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
ChemSrc, established in 2014, is a supplier of pharmaceutical products, a chemical database platform, and a search engine. This platform serves as a gateway to an extensive repository of chemical knowledge, offering access to unique CAS-encoded product records including synthesis routes, literature references, physical and chemical properties, and supplier information. The chemical catalog spans various categories, including organic raw materials, dyes and pigments, chemical pesticides, catalysts, additives, and more. The repository information plays a vital role in supporting research and development efforts across diverse industries by fostering scientific advancements and serving as a valuable resource.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Matrix Fine Chemicals GmbH |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the thiazolidine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 40.0% |
|
Canada
|
1 | 20.0% |
|
United Kingdom
|
1 | 20.0% |
Switzerland
|
1 | 20.0% |
