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This section provides an overview for dihydroxyacetone as well as their applications and principles. Also, please take a look at the list of 16 dihydroxyacetone manufacturers and their company rankings. Here are the top-ranked dihydroxyacetone companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.Hebei Guanlang Biotechnology Co., Ltd..
Table of Contents
Dihydroxyacetone is a white powder with a sweet taste and characteristic odor. Its chemical formula is C3H6O3, molecular weight 90.08, and its CAS number is 96-26-4. Dihydroxyacetone is also known as 1,3-dihydroxypropan-2-one (IUPAC name), DHA, and glycerone.
It was first discovered as a skin coloring agent by a German chemist in the 1920s, when its use in an X-ray irradiation experiment caused the skin surface to turn brown when spilled. Dihydroxyacetone is a 3-carbon ketose, and together with glyceraldehyde is the smallest monosaccharide. It is the simplest ketose without a chiral center and is the only monosaccharide that is not optically active.
One use of dihydroxyacetone is in winemaking. The acetic acid bacteria acetobacter aceti and gluconobacter oxydans both utilize the ketone formation of glycerol in forming dihydroxyacetone. This formation is most likely responsible for the sweet, ethereal characteristics of the wine's aroma. Dihydroxyacetone is said to influence the antimicrobial activity of wine because of its ability to bind to sulfur dioxide.
Other uses include an active ingredient in tanning skin care products. Common commercial products using dihydroxyacetone range from 3-5%, while professional products contain anywhere from 5-20%. They are available for coloring levels ranging from light to dark, and products with lower concentrations are easy to use for beginners.
However, multiple coats may be required to produce the desired color. Artificial tanning takes 2-4 hours to begin to appear on the skin surface, and the color darkens over a period of 24-72 hours, depending on the type of formulation.
Dihydroxyacetone has a melting point of 82°C, a boiling point of 188°C, and a vapor pressure of 5.8 x 10-6 kPa/25°C. It has high solubility in water, but is somewhat insoluble in alcohols such as ethanol and insoluble in acetone.
Dihydroxyacetone normally forms a dimer, but in aqueous solution it changes to a monomer and becomes slightly acidic with a pH of 4 to 6. When it adheres to the skin, it reacts with amino acid residues of keratin, a protein on the skin surface, and turns yellow or brown. The pigment of the coloring component varies depending on the amino acid residue that reacts, but is collectively called melanoidin.
Dihydroxyacetone can be synthesized by the gentle oxidation of glycerol with the structural isomer glyceraldehyde, using hydrogen peroxide and ferrous salts as catalysts. It can also be synthesized from glycerol in high yield and selectively at room temperature, also using cationic palladium catalysts with oxygen, air, or benzoquinone acting as co-oxidants.
Precautions for handling and storage are as follows:
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Hebei Guanlang Biotechnology Co., Ltd., founded in 2007 and headquartered in Shijiazhuang, Hebei, is an ISO9001, ISO14001 and ISO 45001 manufacturer of chemical raw materials and pharmaceutical intermediates. Its range of products include pharmaceutical products, food grade additives, mineral products, veterinary drug intermediates and dye intermediates among others. The company also provides various daily & industrial chemicals as well as cosmetic raw materials. The company has branches in Hubei China, Vietnam and Mexico to expand their sales network.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
Zhengzhou Alfa Chemical Co., Ltd. (ZACC) is a manufacturer of organic chemicals and catalysts established in 2010 and based in Jiaozuo, Henan. The company primarily produces pharmaceutical and organic intermediates as well as photoelectric materials for customers in life science, polymers, dyes, and metallurgy. The company's product lineup includes condensed ring compounds, heterocyclic compounds, COFS/MOFS, and metal catalysts. These supply client corporations such as Bayer AG, Pfizer Inc., and Sumitomo Chemical Company, Ltd. ZACC also offers gram- to ton-level contract synthesis and production services.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Tianjin YR Chemspec Technology Co., Ltd., established in 2012 and headquartered in Tianjin, China, operates as a manufacturer and distributor of a diverse variety of specialty products, raw materials, additives, intermediates, and solvents worldwide. The company is commonly recognized as a reputable global provider of quality performance raw materials, additives, laboratory and research chemicals, and other fine chemical products. The organization consistently prioritizes the execution of a sustainable development plan, which centers around achieving a harmonious balance between human activities and the natural environment to foster a civilized approach to development.
Shanghai Theorem Chemical Technology Co., Ltd., established in 1997, is a company located in Shanghai, China, is a manufacturing company specializing in researching and manufacturing chemical new materials and fine chemicals. The company offers new functional materials, surfactants, polyurethane chemicals, special isocyanates, extractants, and more. They have a product chain advantage and offer professional technical support, and stable production supply with authorized ISO9001 quality management system, ISO14001 environmental management system, as well as related certifications. Their manufacturing factory with a land area of 80,000 m2, has over 300 workers, 30 engineers, 7 production workshops.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ataman Kimya, established in 2006, is a distributor of chemicals based in Istanbul, Turkey. Their wide range of products includes detergents, cosmetics, disinfectants, pharmaceutical chemicals, and water treatment chemicals. They also offer textile, leather, paper, and mining chemicals. These chemicals, such as hydrogenated castor oils, ethanol, and butylene glycol, find applications in various industries, such as personal care, household cleaning, fragrance, coatings, and agriculture. The company also offers custom blending to meet specific requirements.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
66.7%
|
| 2 | Hebei Guanlang Biotechnology Co., Ltd. |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the dihydroxyacetone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
6 | 46.2% |
|
India
|
4 | 30.8% |
|
Japan
|
2 | 15.4% |
|
Germany
|
1 | 7.7% |
