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This section provides an overview for dichloroacetic acids as well as their applications and principles. Also, please take a look at the list of 11 dichloroacetic acid manufacturers and their company rankings. Here are the top-ranked dichloroacetic acid companies as of December, 2024: 1.Hangzhou Longshine Bio-Tech Co.,LTD, 2.KANTO CHEMICAL CO.,INC., 3.Junsei Chemical Co.,Ltd..
Table of Contents
Dichloroacetic acid, represented by the chemical formula CHCl2COOH, is a variant of acetic acid. This colorless liquid is characterized by its pungent odor, higher acidity compared to acetic acid, and deliquescent properties. It is water-soluble and miscible with acetone, ether, and ethanol.
Formed as a disinfection byproduct during water purification, it arises when organic substances, bromine, and chlorine react in raw tap water. It is regulated under various laws as a poisonous and deleterious substance and a flammable liquid.
Dichloroacetic acid serves primarily as an intermediate in organic synthesis and pharmaceuticals, leading to the production of its salts and esters, test reagents for fiber analysis, and disinfectants. Its derivatives, including sodium dichloroacetate, are explored for anticancer properties and potential therapeutic effects.
Appearing as a colorless to light reddish-brown liquid, dichloroacetic acid has a molecular weight of 128.94 and a CAS number of 79-43-6. It has a melting point of 5-6°C, a boiling point of 194°C, and a density of 1.563 g/cm3. While stable under normal conditions, exposure to light can affect its stability, leading to decomposition products like carbon monoxide, carbon dioxide, and halides.
GHS classifies it as posing risks of metal corrosion, acute dermal toxicity, skin and eye damage, mutagenicity, carcinogenicity, reproductive toxicity, specific target organ toxicity, and environmental hazards. It can cause severe skin and eye irritation, genetic mutations, carcinogenic effects, and damage to fertility or unborn children. Risks include respiratory system damage and, with long-term exposure, potential harm to the central nervous system, liver, pancreas, kidneys, and male reproductive organs.
In case of inhalation, move the affected person to fresh air and seek medical attention if symptoms persist. For skin contact, remove contaminated clothing and wash the area with soap and water. If ingested, rinse the mouth and seek immediate medical help, especially if the person is unconscious. Always bring the chemical's SDS and other relevant manuals when seeking medical assistance.
Ensure proper ventilation and local exhaust systems in indoor workspaces. Provide safety showers, and eye washing stations, and wear appropriate protective gear, including masks, gloves, and goggles. Follow proper disposal methods for contents and containers, and maintain hygiene by avoiding consumption of food or beverages and washing thoroughly after handling.
Store in cool, well-ventilated, light-protected, sealed areas. Use corrosion-resistant containers and keep away from incompatible materials.
Tap water standards mandate a maximum dichloroacetic acid concentration of 0.03 mg/L. Given its formation during water purification, eliminating it from tap water is challenging.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Hari Orgochem Pvt. Ltd, founded in India in 1985, is a manufacturer of Trichloroacetyl Chloride (Agrochemical Intermediate for Chlorpyrifos) and Pivaloyl Chloride (Pharmaceutical and Agrochemical Intermediate). The company produces Trichloroacetyl Chloride which is an essential intermediate in the production of various pharmaceutical compounds, and in the synthesis of agrochemicals, contributing to efficient crop protection. It utilizes over 50 Glass Lined Reactors and can produce 8000 MT per annum of Acid Chlorides.
Hangzhou Keying Chem Co., Ltd. (HKC) is a Chinese manufacturer of fine chemicals and polymers that was established in 2010. Based in Hangzhou, Zhejiang, the company offers various fine chemicals such as reagents and catalysts, as well as polymers, active pharmaceutical ingredients (APIs), and feed additives. It also produces specialty chemicals including pesticides and natural as well as synthetic dyes. HKC products are used by clients in the agricultural and industrial sectors, including Mitsubishi Chemical, Sanofi, and Dow AgroSciences.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Hangzhou Longshine Bio-Tech Co., Ltd., established in 2011 and headquartered in Hangzhou, Zhejiang, China, is a manufacturer and supplier of pharmaceutical and chemical goods. The company offers a wide range of products, including API and intermediates, conjugated estrogens, beta-alanine, adrenaline tartrate, and 5-bromopyridine-2-carbaldehyde. These chemical products serve various purposes, such as being potent orally active estrogen receptor antagonists with anticancer properties, regulating animal physiology, diagnosing animal diseases, and providing treatments for conditions like erectile dysfunction.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Hangzhou Longshine Bio-Tech Co.,LTD |
22.2%
|
| 2 | KANTO CHEMICAL CO.,INC. |
22.2%
|
| 3 | Junsei Chemical Co.,Ltd. |
16.7%
|
| 4 | Sujan Chemicals Industries |
11.1%
|
| 5 | Hangzhou Keying Chem Co., Ltd. |
11.1%
|
| 6 | A. B. Enterprises |
5.6%
|
| 7 | Glentham Life Sciences Limited |
5.6%
|
| 8 | Merck |
5.6%
|
Derivation Method
The ranking is calculated based on the click share within the dichloroacetic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 50.0% |
|
Japan
|
2 | 20.0% |
|
China
|
2 | 20.0% |
|
United Kingdom
|
1 | 10.0% |
