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This section provides an overview for l-cysteine as well as their applications and principles. Also, please take a look at the list of 8 l-cysteine manufacturers and their company rankings. Here are the top-ranked l-cysteine companies as of December, 2024: 1.Daily Manufacturing, 2.Wego Chemical Group Inc, 3.Central Drug House.
Table of Contents
Figure 1. Basic Information on L-Cysteine
L-cysteine is a nonessential amino acid characterized by a thiol group on its side chain.
Its abbreviation is Cys, and L-cysteine is the naturally occurring form. It plays a role in reducing the production of melanin, which causes skin pigmentation, and promotes its elimination from the body.
L-cysteine, being a constituent of proteins, reacts with acetaldehyde, a primary cause of hangovers, neutralizing its toxicity. Its effectiveness in mitigating hangovers has led to its use in health supplements.
L-cysteine is used in pharmaceuticals and as a food additive. It exhibits antioxidant properties in the body and aids in liver detoxification.
Its applications include use in anti-allergic medications, treatments for skin conditions, and as a countermeasure against leukopenia resulting from radiation exposure. It is also valued in cosmetic supplements for its skin-lightening effects when combined with vitamin C.
Additionally, it is popularly employed as a remedy for hangovers.
L-cysteine, a protein-building amino acid, is glycogenic. It exhibits specific optical rotation [α]D of +9.4° and decomposes at 240°C.
The thiol group in L-cysteine serves as a nucleophilic catalyst and displays high reactivity. The pKa of this group is around 8, varying with environmental conditions.
Figure 2. Structure of L-Cysteine
L-cysteine is 2-amino-3-sulfanyl propionic acid, considered hydrophobic or having a neutral polar side chain.
Due to its chiral carbon atom, it exists as R-cysteine (L-cysteine) and S-cysteine (D-cysteine). By the rank order rule, L-cysteine uniquely assumes the R configuration. Its chemical formula is C3H7NO2S with a molar mass of 121.16 g/mol.
Biosynthesis in animals begins with serine, converting methionine to homocysteine, then to cystathionine via cystathionine β-synthetase, and finally to L-cysteine.
In plants and bacteria, L-cysteine is synthesized from serine through O-acetylserine, with cysteine synthase facilitating the final step.
Figure 3. Disulfide Bonds in L-Cysteine
L-cysteine forms cystine upon oxidation, which involves the linkage of two L-cysteine molecules via a disulfide bond.
This oxidized form, referred to as cystine, loses its nucleophilic properties.
L-cysteine's thiol group facilitates protein cross-linking via disulfide bonds, crucial for the stability and functional integrity of proteins both inside and outside the cell.
For instance, insulin's structure and function are dependent on disulfide bonds between L-cysteine residues, demonstrating its significance in biochemistry.
*Including some distributors, etc.
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Daily Manufacturing is a manufacturer specialized in dietary supplements and nutritional products, headquartered in the United States, and established in 1979. The company serves industries such as health and wellness, dietary supplements, and nutraceuticals. Its portfolio includes a wide range of dietary supplements, vitamins, minerals, and herbal products, among others. Its products find diverse applications in these industries by promoting health and well-being, supporting nutritional needs, and contributing to a healthier lifestyle.
FabriChem, founded in Milford, Connecticut, in 1993 is a supplier of chemical ingredients for raw material sourcing and custom contract manufacturing. The company's product portfolio includes Specialty & Fine Chemicals, Pharmaceutical Ingredients, Biochemicals, Diagnostics & Buffers and Cosmetic & Oral Care Ingredients. The company serves markets such as research centers, testing and diagnostic labs, healthcare and educational institutions. They also provide services such as Product Selection Guidance, quality control and Custom Manufacturing.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Graham Chemicals, established in 1988 is a global chemical distribution firm. Situated in Illinois, USA, they offer superior specialty chemical intermediates, surfactants, and performance additives. Some of their focuses include food, flavor, and fragrance industries and industrial and institutional markets. They also provide manufacturing services such as food grade and technical blending, reactions, and milling through their extensive supplier network. With their reliable services and competitive prices, they are known as one of the preferred chemical distributors in the United States.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Anant Pharmaceuticals Pvt. Ltd., established in 2005, is a supplier of pharmaceutical impurity reference samples and custom synthesis and analytical services, based in India. The company delivers novel solutions to research and development teams. Their organic synthesis labs are equipped with modern equipment, designed with energy saving concept. Over the years, they have developed into a one-stop service provider for bespoke chemical synthesis and analytical services for a wide range of industries in India and abroad.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Daily Manufacturing |
25.7%
|
| 2 | Wego Chemical Group Inc |
18.6%
|
| 3 | Central Drug House |
15.7%
|
| 4 | Graham Chemical |
10.0%
|
| 5 | Glentham Life Sciences Limited |
8.6%
|
| 6 | FabriChem |
7.1%
|
| 7 | Shree Sai Life Sciences |
7.1%
|
| 8 | Anant Pharmaceuticals Pvt. Ltd. |
7.1%
|
Derivation Method
The ranking is calculated based on the click share within the l-cysteine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 57.1% |
|
India
|
2 | 28.6% |
|
United Kingdom
|
1 | 14.3% |
