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This section provides an overview for cyclooctatetraene as well as their applications and principles. Also, please take a look at the list of 8 cyclooctatetraene manufacturers and their company rankings. Here are the top-ranked cyclooctatetraene companies as of December, 2024: 1.Ereztech LLC.
Table of Contents
Cyclooctatetraene (COT), with the molecular formula C8H8, is a cyclic unsaturated hydrocarbon, and a member of the annulenes, specifically [8]annulene. Its CAS number is 629-20-9. This compound, a colorless or pale yellow liquid at room temperature, is known for its distinct odor and is insoluble in water but soluble in organic solvents like ether, benzene, and ethanol.
With a molecular weight of 104.149, COT has a melting point of -3 °C and a boiling point of 143 °C. It is slightly hygroscopic and gradually polymerizes in air.
COT is used in the synthesis of organic films for silicon surfaces, liquid-state organic dye lasers, and as a triplet-state quencher. It's a valuable synthetic intermediate for various cyclic compounds and raw material for chemicals like terephthalaldehyde and phenylacetaldehyde.
COT is synthesized via Reppe synthesis, involving the polymerization of acetylene in tetrahydrofuran using nickel cyanide as a catalyst under high pressure. It was first synthesized from natural pelletierine by Richard Willstätter in 1912.
COT is an 8π electron system and is non-aromatic, as it doesn't adhere to the Hückel rule for aromaticity. It adopts a boat conformation and is reactive to addition, rearrangement, and oxidation reactions. Interestingly, reactions like those with potassium can convert COT from non-aromatic to aromatic, forming a dianion that satisfies the Hückel rule.
COT is primarily used as a research reagent and is available in small quantities, typically sold in glass bottles and requiring refrigerated or frozen storage. It often contains a small percentage of polymerization inhibitors like hydroquinone due to its propensity to polymerize.
Related compounds like cyclooctatetraene iron tricarbonyl, where COT acts as an iron ligand, are also marketed for research and development purposes.
*Including some distributors, etc.
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Ereztech was founded in 2010 and headquartered in Johns Creek, Georgia with manufacturing in Sheboygan Falls, Wisconsin. Ereztech is a provider of organometallic precursor R&D and manufacturing services for global customers. Ereztech in ISO 9001:2015 certified. Ereztech offers over 1200 chemical compounds and materials including high purity silver sulfate and aluminum nitrate. In addition to these materials, Ereztech offers full-service production and packaging from synthesis samples to high-volume manufacturing quantities. This includes fully customized vessel cleaning procedures, detailed, custom workflow processes specific to each material and vessel, inventory management system, and beginning to end quality control.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Fisher Scientific UK Ltd is a supplier of laboratory chemicals, equipment, and services based in Loughborough, United Kingdom, operating as a subsidiary of Thermo Fisher Scientific, a merger of Fisher Scientific International, Inc. and Thermo Electron in 2006. With a portfolio of over 2 million products, Fisher Scientific offers chemicals, reagents, equipment and instruments, consumables, and safety products. These products cater to various sectors, including clinical diagnostic and research laboratories, pharmaceutical and biotech industries, healthcare, and government agencies. Fisher Scientific also provides business solutions like the New-Lab Start-Up program, as well as SureTRACE and SureTRACE+ for product knowledge and supply chain management.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Ereztech LLC |
40.0%
|
| 2 | Tokyo Chemical Industry Co., Ltd. |
40.0%
|
| 3 | MilliporeSigma |
20.0%
|
Derivation Method
The ranking is calculated based on the click share within the cyclooctatetraene page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United Kingdom
|
2 | 33.3% |
|
United States of America
|
1 | 16.7% |
|
Canada
|
1 | 16.7% |
|
Japan
|
1 | 16.7% |
|
Switzerland
|
1 | 16.7% |
