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This section provides an overview for oxamide as well as their applications and principles. Also, please take a look at the list of 11 oxamide manufacturers and their company rankings. Here are the top-ranked oxamide companies as of December, 2024: 1.AK Scientific, Inc, 2.CRS Chemicals, a division of C.R. Supply Co., 3.Spectrum Chemical Mfg. Corp..
Table of Contents
Oxamide is an organic compound in the form of a white crystalline powder.
Its IUPAC name is ethanediamide. It is also known as oxalic diamide, diaminoglyoxal, oxalamide, oxamimidic acid, oxalic acid diamide, oxalic acid diamide Oxalic acid diamide, 2-Amino-2-oxoethanimidic acid.
Oxamide is used as a slow-acting fertilizer that gradually imparts fertilizer into the soil after application. It is an excellent fertilizer because it is insoluble in water and does not absorb moisture, so there is little runoff to groundwater. It is also hydrolyzed over time by microorganisms in the soil, gradually releasing ammonia.
The decomposition rate of Oxamide and the release rate of ammonia can be adjusted according to particle size, making it easy to use and effective for labor-saving crop cultivation. Oxamide's decomposition mechanism in the soil involves the release of a single molecule of ammonia to produce oxamic acid, which is then further decomposed into oxalic acid and ammonia.
The final decomposition products of oxalic acid are water, oxygen, and carbon dioxide. Since the decomposition products do not contain harmful byproducts such as sulfuric acid or chlorine, there is no adverse effect on the soil microbial environment, soil components, or crop growth. Oxamide itself is stable in air and is only hydrolyzed under alkaline conditions above pH 10 or acidic conditions below pH 1.
Oxamide is also used as a stabilizer in nitrocellulose synthesis. It is also useful as a high-performance burn rate inhibitor in a fuel called ammonium perchlorate complex propellant (APCP). Oxamide at concentrations of 1-3 wt% can retard linear burn rate with minimal effect on propellant-specific impulse.
In addition, N, N'-substituted oxamides are used as auxiliary ligands in the Ullmann-Goldberg reaction. The Ullmann-Goldberg reaction is a coupling reaction of aryl halides and anilines in the presence of a copper catalyst. Among aryl halides, aryl iodide is known to be highly reactive. Aryl halides with electron-withdrawing groups also facilitate the coupling.
Oxamide has the chemical formula C2H4N2O2 and a molecular weight of 88.07. It is registered under CAS No. 471-46-5.
Oxamide is a solid with a density of 1.667 g/ml (20°C) that dicyanically decomposes with water at 350°C (melting point). It forms needle-like crystals and is partially sublimable. It is soluble in ethanol, almost insoluble in water, and insoluble in diethyl ether.
Oxamide is obtained by the action of ammonia on diethyl oxalate. It can also be synthesized by partial hydrolysis of dicyanogen or by heating ammonium oxalate, the ammonium salt of oxalic acid.
Handling Precautions
Oxamide is designated as a dangerous substance when handled in contact with oxamide. Take care not to come in contact with it when handling or storing.
When handling, be sure to wear protective clothing, protective glasses, and protective gloves, and use them in a draft chamber. Wash hands after use.
In Case of Fire
Decomposition by combustion may produce carbon monoxide (CO), carbon dioxide (CO2), and nitrogen oxides (NOx). Use a powder fire extinguisher, foam, water spray, or carbon dioxide (CO2) to extinguish the fire. There are no prohibited fire extinguishing media.
In Case of Skin Contact
Oxamide is a skin irritant. If it gets on the skin, wash thoroughly with soap and plenty of water. If skin irritation or rash occurs, seek medical advice and attention. Wash contaminated clothing if it is to be used again.
In the Case of Eye Contact
Oxamide is a strong eye irritant. In the event of eye contact, rinse the eye carefully with water for several minutes. If eye irritation persists, seek medical attention.
Storage
Keep the container tightly closed in a cool, dark place. Store away from incompatible hazardous materials.
*Including some distributors, etc.
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AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
CRS Chemicals, founded in 2005, functions as a purveyor of chemical solutions based in the United States. The company's core aim involves supplying a diverse spectrum of industrial chemicals, cleansing agents, and solvents to a broad spectrum of sectors. Operating as an ally in domains like manufacturing, aerospace, and automotive, CRS Chemicals exhibits its partnership prowess. CRS Chemicals presents an array of substances encompassing solvents, degreasers, rust inhibitors, and custom chemical solutions. \The organization's devotion to ecological sustainability is evident through its environmentally conscious alternatives and customized formulations, underscoring its devotion to accommodating unique client requisites while minimizing ecological footprints
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
California Pacific (CP) Lab Safety is an American manufacturer and distributor of laboratory safety solutions founded in Novato, California in 1996. The company produces both lab and environmental safety equipment and devices, including waste containers, safety vents, biodegradable bags, and personal protective equipment (PPE). They also offer custom design and engineering services for customer projects, as well as technical support and quality assurance. CP Lab Safety serves California’s government agencies, departments and offices, as well as clients in its research, education, and healthcare institutio.
United States Biological, located in Salem, Massachusetts, is a manufacturer and supplier of life science research products. Its product offerings include biochemicals, antibodies, and molecular biology kits. The company’s products are used in various fields such as genomic research, biotechnology, and pharmaceutical development. Products are available from affordable research quantities to larger bulk amounts for process development and production. Its customer base comprises pharmaceutical and biotechnology companies both in the US and overseas.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | AK Scientific, Inc |
22.2%
|
| 2 | CRS Chemicals, a division of C.R. Supply Co. |
22.2%
|
| 3 | Spectrum Chemical Mfg. Corp. |
11.1%
|
| 4 | Alfa Aesar, Thermo Fisher Scientific. |
11.1%
|
| 5 | KANTO CHEMICAL CO.,INC. |
11.1%
|
| 6 | Merck |
11.1%
|
| 7 | United States Biological |
3.7%
|
| 8 | CP Lab Safety |
3.7%
|
| 9 | MilliporeSigma |
3.7%
|
Derivation Method
The ranking is calculated based on the click share within the oxamide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 62.5% |
|
Japan
|
1 | 12.5% |
|
Switzerland
|
1 | 12.5% |
|
United Kingdom
|
1 | 12.5% |
